Cushing ọrịa - a ọrịa na pituitary hyperfunction

Cushing si Disease ma ọ bụ Cushing si - a ọrịa nke e mere site a mebiri nke hypothalamus, pituitary na adrenal glands na mmepe nke mgbagwoju ọnya. The ọrịa mbụ kọwara H. Cushing na 1924, na 1932 Cushing jikọrọ ya mmepe na pituitary adenoma.

Na-akpata Cushing ọrịa bụ a basophilic adenoma nke pituitary ihu n'ọnụ ọnụ ma ọ bụ na-amụba ọnụ ọgụgụ nke basophilic pituitary mkpụrụ ndụ. Mgbanwe ndị a nwere ike ịrụpụta traumatic ụbụrụ na mkpaghasị uche, ụbụrụ, endocrine ọrịa.

The ndabere nke ọrịa - hyperproduction nke pituitary adrenocorticotrophic hormone, nke na-akpata na-abawanye na njikọ nke cortisol site adrenal glands.

Cushing ọrịa - adakarị picture

The ọrịa amalite nwayọọ nwayọọ. Ọrịa mkpesa nke n'ozuzu adịghị ike, iro ụra, enweghị mmasị, na-aga n'ihu ibu oké ibu. Ibu emetụta tumadi elu ọkara nke ahu. N'ihi ya, ọrịa kpụrụ ọnwa ihu, zuru n'ubu, n'úkwù, na a disproportionately mkpa, atrophic forearms na ikpere. E nkụ na ekpepụsị nke anụ, ahụ ntutu na nwoke ụkpụrụ na ndị inyom, na a n'otu oge ọnwụ nke ntutu isi na isi, feminization mmadụ. Na akpụkpọ nke afo, n'ubu, ara apụta dystrophic obosara n'ọnyá nke ọbara ọbara-acha odo odo na agba. N'ime oge ahụ, na-emepe emepe muscle atrophy aka na ụkwụ, belata ike ha. Emepe emepe ọbara mgbali na gbasara akụrụ ọrịa, ọrịa ụbụrụ nsogbu na atherosclerosis.

Cushing ọrịa na-eduga ná a mebiri nke ịnweta metabolism, n'ihi nke bụ mmepe nke osteoporosis. N'ihi osteoporosis na-obibi na abịakọrọ akwara mgbọrọgwụ, e nwere oké ihe mgbu na nsọtụ, spain, mepụtara a curvature nke thoracic spain na guzobere kyphosis, enweghị nchịkwa fractures. calcium na cholesterol n'ime ọbara na-abawanye. Gbochie absorption nke glucose, n'ihi na-emepe emepe-arịa ọrịa shuga. Mụbara ọchịchọ-imepe-agba ọbara, agụghị oké agwọ ọnyá. Ọrịa mkpesa nke mmekọahụ dysfunction, ebelata libido na potency, apụta ịhụ nsọ ọrịa. Ekwe Omume neuroses, ịda mbà n'obi, hypochondria, psychosis.

Nke obi amalite hypertrophy nke ekpe ventricular tachycardia, ịza aza sekọndrị ọbara mgbali. Mgbe akụrụ na-amụ na-ekpughe proteinuria, ebelata glomerular filtration ọnụego na gbasara akụrụ ọbara. Ikekwe mmepe nke gbasara akụrụ n'ichihịa kọrọ ọrụ nke ndị a akụkụ. Ụfọdụ ọrịa na akụrụ nkume na-ahụrụ.

nchoputa nke ọrịa

Cushing ọrịa na-chọpụtara na-ejide a okpokoro isi x-ray na mmetụta na-amụ sella, agbakọrọ tomography nke okpokoro isi, na adrenal glands, vaskụla ọmụmụ - angiography. Laboratory ule chọpụta larịị nke na hormone cortisol n'ime ọbara na ego nke Corticosteroid na mmamịrị.

Cushing ọrịa - Ọgwụgwọ

Ahọpụta ọgwụgwọ n'ụzọ dị ukwuu na-adabere na-akpata ọrịa na ịdị njọ nke-adakarị ngosipụta nke ọrịa.

Na mmalite nkebi kenyere ọgwụ ọgwụ ọjọọ na belata secretion nke adrenocorticotropic hormone na corticosteroids. Eji dị antihypertensive ọgwụ ọjọọ, symptomatic ọgwụ. N'ezie nke ọgwụgwọ dịruru ruo ọnwa asatọ. Ọ bụrụ na enweghị mmetụta, oké iche nke ọrịa, nye iwu ka Nchikota ọgwụ esịnede radieshon ọgwụ na ịwa ahụ (mwepụ nke pituitary ma ọ bụ adrenalectomy).