Interferon inducers, ọgwụ ọjọọ maka ụmụaka: a ndepụta nke edinam. Ngwa-ngwa-eme inducer nke endogenous interferon

N'ihi nzube nke mgbochi na ọgwụgwọ nke malitere ịrịa ọrịa interferon inducers eji. Ha usoro nke edinam jikọtara mmepe nke protein bekee gbochie multiplication nke pathogens. dabeere inductors ọgwụ ọjọọ nwere ike na-alụ ọgụ akụkụ okuku ume na ọrịa, herpes na hepatic-efe efe na influenza.

Mkpebi siri ike nke interferon

N'ihi ya, bụ otu ìgwè nke ogige enwe protein malite. Ha na-emepụta mkpụrụ ndụ na-ebute oria site malitere ịrịa pathogens.

Interferon bekee ihe nke na-abụghị kpọmkwem agbachitere usoro ke idem megide nje, chlamydial, opportunistic fungal-efe efe, akpụ cell owuwu. Ha na-egwu ọrụ nke regulators nke intercellular interactions systemic ọgụ. Ha na-akpọ immunomodulators na endogenous okike.

E nwere ọtụtụ iche nke ụmụ mmadụ interferon bekee leukocyte ma ọ bụ a-interferon, fibroblast, ma ọ bụ b-interferon, na dịghịzi ma ọ g-interferon.

Na-akwọ ụgbọala usoro nke ọrụ amalite na nkịtị na-edozi na-anabata ya na mkpụrụ ndụ nke a akpan akpan okike. Mgbe ihe dị otú ahụ na mmekọrịta na-synthesized protein ụmụ irighiri n'ime iri atọ. Na mmetuta nke usoro iwu peptides rụrụ ọrụ nke T-lymphocytes na macrophage-ụdị owuwu emee gbochie ingress nke nje site na cell akpụkpọ ahụ na ha amụba. Ọ bụ ha na onye na-ahụ maka nchebe Njirimara.

Natural interferon inducers - a malitere ịrịa mkpụrụ ndụ na abatawo n'ime ndụ ahụ. Ha nwere ike, na-adịghị ike stimulators nke mmepụta nke na-echebe na-edozi. Ọtụtụ n'ime ndị mmadụ nke dị oké njọ ọrịa ndị ogbenye inducers. Ndị a gụnyere cytomegalovirus na HIV, herpes, ịba ọcha n'anya C na B ụdị Ma ọtụtụ nke pathogens na-eme ka akụkụ okuku ume na malitere ịrịa ọrịa, na-atụle nke nwere ike stimulators nke mmepụta nke na-echebe na-edozi.

Interferon inducers (ọgwụ ọjọọ): ihe ọ bụ

A na ọ na-ezo aka a na klas nke sịntetik ọgwụ ọjọọ immunomodulators. Ha na-emepụta site na-emepụta ọgwụ na ụlọ ọrụ. Interferon inducers (ọgwụ ọjọọ) na-họọrọ dị ka a nnukwu klas nke dị iche iche chemical Ọdịdị nke ahụ ogige. Ifịk ifịk mmiri nwere ike ala-na-na-elu-molekụla umi, a sịntetik ma ọ bụ eke si malite. Ha na-a nkịtị mma, nke na-enye ohere ahụ ime na mkpụrụ ndụ nke gị onwe gị, ma ọ bụ endogenous interferon. Ndị dị otú ahụ preparations pụrụ igosipụta antiviral na immunomodulating mmetụta.

Esi etinye

Inducers nke endogenous interferon - preparations iji, ọtụtụ mgbe, na-alụ ọgụ malitere ịrịa ọrịa. The usoro nke mmetụta ha dabeere na kọntaktị na-arụsi ọrụ ike iji ọgwụ umi cellular na anụ ahụ ọdịnaya nke utịp ke mmepụta nke a na-echebe protein.

Interferon inducers - Pharmaceuticals ọdịdị na welie iche nke protein artificially. Mmetụta ha yiri a eke stimulants, nke na-agụnye malitere ịrịa, nje na mkpụrụ ndụ dị iche iche bekee.

The ojiji nke interferon inducers nwere ike ime ka hyporesponsiveness. Na steeti a, n'elu ugboro ugboro ochichi nke ọgwụ na-adịghị ga ịzụlite a na-echebe omume protein, kwuru, ya suppression. Mgbe a na ogbo impractical inye ọgwụ. Na oge nke steeti a kpebisiri ike site inductor. Mgbanwe nke nọ n'ọrụ mgwa, nakwa dị ka nkwụsị nke ọgwụgwọ na otu gị n'ụlọnga enyemaka iji kpochapụ hyporesponsiveness.

Oge akara aka nke ọgwụ ndị na-akpali mmepụta nke na-echebe protein anaghị eme ka oké oghom mmetụta nke chọrọ ka ha mwepụ.

The uru nke inducers nke endogenous protein

E nwere ụzọ abụọ ka welie ọgụ interferon. Nke a compound nwere ike ndinọ ozugbo ma ọ bụ exogenously na organism. Ụzọ ọzọ na-agụnye endogenous interferonizatsiyu na iwebata bekee na-akpali mmepụta nke ya interferon. Nke a protein na-egosi dịghị antigenicity, nke bụ bụghị recombinant interferon. Ogologo okwu ochichi nke a okokụre protein ọgwụ ọjọọ na-eduga ná mmepe nke oghom Jeremaya mere.

Inducers nke endogenous interferon n'ọmụmụ irè gosiri pharmacological ọrụ a iche iche sara mbara nke na-efe efe. Ọ hụrụ ha bifunctional onwunwe, ji akpọ antiviral mmetụta, na immunomodulating mmetụta.

Akparamagwa nke interferon inducers na-eduga ná njikọ nke na-edozi, nke na ha na-eme dị ka njikere echebe edozi. Ndị dị otú ahụ a usoro a na-guzozie eguzozie, ya akara usoro n'ụzọ dị irè na-echebe ndị organism si oké guzobere ndị a ogige.

N'ihi na a otu ngwa nke preparations inducing interferon bụ pụtara ruo ogologo oge mgbasa nke na-echebe protein na chọrọ ọgwụgwọ dose. Iji nweta ndị dị otú ahụ a onunu ogwu ná nhọpụta nke ihe exogenous protein ga-ugboro ugboro ndinọ na nnukwu mpịakọta. Nke a na ọgwụgwọ a na-atụle ga-ọzọ dị oké ọnụ.

List of ọgwụ

Ugbu a, ndị dọkịta na-esiwanye eji interferon inducers - ọgwụ ọjọọ nke depụta n'afọ ọ bụla na-agbakwunye ọhụrụ ọgwụ. A ọnụ ọgụgụ buru ibu nke immunomodulating mmadụ enye gị ohere na-alụ ọgụ ọtụtụ ọrịa.

Dị ka akụkụ nke dịghịzi usoro bụ ugbu functionally interconnected mmiri nke na-ebu si mkpochapu ọhụrụ organism si antigenic ogige. Onye ọ bụla mmewere nwere a kpọmkwem dịghịzi mmadụ. Nke a na-akọwa di iche iche nke ngwaahịa na-eme ka mmepe nke a na-echebe protein.

E nwere dị iche interferon inducers (ọgwụ), na ndepụta nke na-gawa site a ọgwụ ọjọọ, "Poludan". Nke a na ngwá ọrụ a na-ewere nke mbụ stimulator echebe-edozi, nke malitere na-eji ọbụna 70s. Ọ na-agụnye poliuridinovaya na polyadenylic acid. Ya irè bụ ịzụlite interferon obere. Eye tụlee na injections nke ọgwụ "Poludan" emeso herpetic keratitis na keratokonyunktivity. Drug ngwọta na-eme ka ngwa maka ọgwụgwọ nke herpes vaginitis na vulvovaginitis.

Interferon inducers - ọgwụ ọjọọ "Aktaviron", "Lavomax", "Tilaksin" "dihydrochloride tilorona", "Amiksin", "Tiloram" - na Ọdịdị nwere n'ọrụ mgwa tilorona.

Drugs "Ridostin" na "sodium nnu nke abụọ-tọrọ atọ ribonucleic acid" arụpụtara na sodium ribonukleat eme umi.

umifenovir umi esịne ke "Arbidol" Pharmaceuticals, "Arbivir", "Immustat" na "Arpeflyu".

E nwekwara interferon inducers, ọgwụ ọjọọ nke na-akpọ site aha nke-arụ ọrụ bekee. A na-agụnye "Kagocel" mbadamba na "tilorona".

Dabere akridonatsetata meglumine arụpụtara na nkà mmụta ọgwụ "Meglumine akridonatsetat" na "TSikloferon" na oksodigidroakridinilatsetat sodium bụ ugbu a na ọgwụ "Neovir".

The mejupụtara pụtara "Jodantipyrin" na-agụnye 1-phenyl-2,3-dimethyl-4-yodpirazolon, na "Alpizarin" mbadamba nwere magniferrina nnu.

Inductors interferon maka ụmụaka, ha na nkọwa

E nwere ọtụtụ okenye ọgwụ nwere ike e nyere ka a nwa, ma naanị otu onye na-afọ. Ka ihe atụ, ọgwụ ọjọọ, "TSikloferon" na-amalite na-emeso anọ afọ nọ n'agbata, na pụtara "Ridostin" họpụtara afọ asaa. Ma ọgwụ ọjọọ nwere a dịgasị iche iche nke mmetụta. Ha na-adabara maka ọgwụgwọ nke akụkụ okuku ume na ọrịa nke malitere ịrịa uwa, na steeti influenza, ala ala ịba ọcha n'anya, herpes ọrịa. Ha mwepu bụ na o kwere omume ekwesighi n'akụkụ Jeremaya mere.

Interferon inducers - preparations na-e kpọmkwem maka ụmụaka na nwa akpan akpan ụdị. "Arbidol" Ụfọdụ n'ime ha na-a n'aka. Ọ na-eji na-afọ abụọ. Children agwọ ọrịa n'ụdị arụpụtara n'ụdị capsules maka esịtidem ochichi. The nkwadebe nwere antiviral na immunomodulatory mmetụta.

Ọ na-akọ na antiviral mmadụ na inhibit virus cell B na A ụdị. Na ya na-ekere òkè kpaliri mmepụta nke esịtidem interferon, nke na-egbochi na kọntaktị ma penetration n'ime cell ọrịa. N'okpuru ihe nke na-echebe lipid malitere ịrịa envelopu protein bụghị ike jikọọ na cell akpụkpọ ahụ.

Interferon inducers maka ụmụaka mee ka na-amụba ọgụ nke humoral ụdị na ha edinam ahụ na-aghọ ndị ọzọ na-eguzogide ọgwụ na-efe efe mmadụ, ọnụ ọgụgụ nke nsogbu.

Drug "Kagocel" nwere a mmetụta yiri na ahụ nwatakịrị ahụ. Ọ na-emepụta na ụdị mbadamba maka esịtidem were. Age ịgba iji ọgwụ - na afọ atọ.

Ọgwụgwọ nke akụkụ okuku ume na ọrịa

Interferon inducers - ọgwụ ọjọọ na-emeso SARS, nke iduga guzobe na mkpụrụ ndụ nke organism a echebe protein. Ha na-na-họpụtara na influenza ọrịa.

The kasị irè n'aka na-atụle ọgwụ dabeere tilorona, nke na-agụnye ọgwụ "tilorona" na "Amiksin". N'ihi na ọgwụgwọ nke influenza na nnukwu akụkụ okuku ume malitere ịrịa ọrịa na-atụ aro iji ihe okenye n'ime 125 mg na a oge. Nke a dose a na-ekesa na n'ụbọchị abụọ mbụ, mgbe ahụ, 125 mg e otu ụbọchị. Course ego nke agwọ ọrịa bụ 750mg.

Ka e si mgbochi eji 125 mg na a oge, mgbe ahụ 6 ụbọchị oyi. Ụdị ndụ ahụ bụ ugboro ugboro banyere izu isii.

dabeere tilorona ọgwụ ọjọọ na-contraindicated na ẹdude onye ekweghị ibe nọrọ, n'oge ime na mgbe ara-udia nwa gị.

Ịnata dị otú ahụ ọgwụ nwere ike ime ka ọgbụgbọ, fever, anabata.

Nkwadebe "umifenovir" nwere interferon-inducing ọrụ, mmetuta nke cellular ụdị ọgụ, ime nke kwụsiri ike nke dum organism ka nje elekọta mmadụ.

Maka mgbochi mgbe na kọntaktị na-arịa ọrịa ndị mmadụ ọgwụ a kwa ụbọchị dose nke 200 mg otu izu. N'oge a kara aka oge nke influenza na akụkụ okuku ume na ọrịa na-eji a kwa ụbọchị dose nke 100 mg na a oge, mgbe ahụ ka a ezumike ụbọchị abụọ. Nke a N'ezie dịruru izu atọ. Maka ọgwụgwọ nke oyi kenyere 200 mg ugboro anọ kwa ụbọchị, ruo ụbọchị atọ.

Drugs na umifenovir bụghị-eji na ẹdude onye ekweghị ibe nọrọ n'oge oké somatic daa ọrịa. Ịnakwere dị otú ahụ ọgwụ nwere ike ime ka nfụkasị Jeremaya mere.

Ọgwụgwọ nke autoimmune ọrịa

Ọrịa ndị dị na-agụnye enweghị nchịkwa na-ekwu na nke ịzụlite-alụso ọrịa ọgụ ma ọ bụ ba uba autoaggressive egbu cell clones omume ike anụ ahụ. Nke a na-eduga ná imebi na mbibi nke ike anụ ahụ, mgbanwe nke nke bụ ihe autoimmune mbufụt.

Ejikari na ọgwụgwọ nke interferon inducers. Formulations ndinọ na autoimmune ọrịa, ndị nwere immunosuppressive edinam.

Maka ọgwụgwọ nke multiple sclerosis ọgwụ ọjọọ gbasaa "Amiksin". Na nwetụrụ ihe ịrịba ama nke nnukwu akụkụ okuku ume na ọrịa uwa, nke ka njọ ọnọdụ kenyere dose of 125 mg ma ọ bụ 250 mg nke ọgwụ mgbe ingestion. Mbadamba na-aṅụ na a ụbọchị, n'ikuku oge - si 6 ụbọchị 12.

N'ihi mgbochi nke gbasasịa sclerosis exacerbation na-kenyere 125 mg nke ọgwụ, 2 ugboro kwa 7 ụbọchị.

Mgbe mgbagwoju nke nọ n'ọrụ na-adọ nke ọrịa na-emeso ẹdude ịrịba ama nke nnukwu ọgwụ e site 10 ruo 125 mg ọ bụla 30 ụbọchị maka 6 ọnwa. Nkwadebe "Amiksin" e kenyere na peptide bioregulators n'ozuzu mmetụta nke na-ebelata ahụ uche na ụba myelin protein.

Jikọtara ọgwụ ọgwụ ọjọọ, "TSikloferon" enye gị ohere mbuso ugboelu na ogbu na nkwonkwo na ọrịa ogbu, systemic ọrịa na-emetụta connective anụ ahụ. Ọrụ ya bụ iji na na suppression nke autoimmune Filiks, nke na-enye mgbochi mkpali na analgesic mmetụta nke okike. Iji n'aka usoro dịghịzi ọnọdụ dị iche iche immunodeficient deviations. "TSikloferon" The ọgwụ na-emepụta na mbadamba ụdị, n'ụdị injectable ngwọta na liniment.

Maka ọgwụgwọ nke ogbu na nkwonkwo ọgwụ na-ndinọ intravenously ma ọ bụ intramuscularly 1 oge kwa ụbọchị. The onunu ogwu nke 250 mg iji mbụ site na iri na abụọ ụbọchị na ọbụna ụbọchị. Na nnukwu ọrịa na-emetụta ụba mbụ dose nke 500 mg.

Agwọ nke Malitere ịrịa Diseases

Drug "Amiksin" na-ezo aka interferonovym inductors fluoreonovogo ala molekụla arọ òtù. Na ya na-ekere òkè kpụrụ niile iche nke na-echebe na-edozi, nke larịị otu ụbọchị mgbe ngwa nke agwọ ọrịa esịmde ya kasị elu bara uru na plasma.

The na nkà mmụta ọgwụ nwere a nnukwu iche iche nke antiviral edinam. Ke adianade akụkụ okuku ume na ọrịa, ọ na-eji na ịba ọcha n'anya C na nnukwu na-adịghị ala ala, ntighari Genital herpes, cytomegalovirus ọrịa na chlamydial ụdị.

Ọtụtụ antiviral ọgwụ ọjọọ eme ihe - interferon inducers, sokwa bụ ụzọ nke "Neovir". Na ya na-ekere òkè, ọ na-arụpụta a nnukwu ego nke na-echebe protein, karịsịa fibroblast-ụdị, nke na-akọwa na immunomodulatory, mgbochi malitere ịrịa na mgbochi akpụ mmetụta nke a ọgwụ. Drug "Neovir" emeso ụbụrụ, ịba ọcha n'anya C na B, urethritis, cervicitis, salpingitis mere site Chlamydia.

Ọzọ yiri inducer echebe protein bụ a ala molekụla ibu ọgwụ ọjọọ, "TSikloferon", nke na-eji maka njikọ karboksimetilenakridona methylglucamine nnu. Na ya na-ekere òkè kpụrụ Alfa interferon, ọdịnaya nke nke na-echekwara na na lymphoid anụ ahụ ruo ụbọchị atọ.

B lymphocytes T na B-ụdị macrophages bụ guzobere a echebe protein ebighị na ụbụrụ azuokokoosisi owuwu ọkpụkpụ, mmetuta nke mmepụta nke granulocyte nkeji. The ọgwụ na-eji na akọrọ na-ekesa ụbụrụ, herpes, ịba ọcha n'anya, cytomegalovirus, mmadụ immunodeficiency virus na papillomas.

Ọzọkwa antiviral ikpughe n'aka nwere ọrụ nnukwu na-adịghị ala ala nje chlamydia, mbufụt erysipilatous uwa, bronchitis, postoperative nsogbu, genitourinary na-efe efe, ọnyá ọnya.

Ọ pụtara na ahịa a na-emepụta ọgwụ ọgwụ ọjọọ, "Lavomax" emepụta "Nizhpharm" ugbu a. Ọ nwere immunomodulatory mmetụta, ike nke na-inducing interferons, antiviral mmetụta a nnukwu iche.

Dị ka akụkụ nke "Lavomax" mbadamba ẹdude 125 mg tilorona ka n'ọrụ compound. The ọgwụ bụ ihe analogue nke ọgwụ "Amiksin". Ọrụ na-eduzi ndị na mmalite ọgbọ nke atọ ụdị interferon na T-lymphocytes, hepatocytes, epithelial mkpụrụ ndụ nke nsia mgbidi.

Mmetụta immunomodulating mmetụta bụ n'ihi weghachi itule n'etiti dịghịzi mkpụrụ ndụ na normalisation nke antibody mmepụta. Ndabere nke usoro nke antiviral ọrụ bụ mgbochi nke protein njikọ, kpọmkwem nje na nje ebe nke ahu. Nke a na-emegide iwu ha n'ihu amụba.

Flu-dị ka ọgwụ na-aga nke ọma na-emeso ọnọdụ, ọrịa, akụkụ okuku ume na uwa, malitere ịrịa ịba ọcha n'anya na herpes ọkụ ọkụ.

Inductors ngwa ngwa ihe

N'ozuzu, ochichi nke ndị dị otú ahụ ọgwụ na-eduga na-ebu ọnụ mmepe nke a na-echebe protein.
Ngwa-ngwa-eme inducer nke endogenous interferon n'ime awa ole na ole nke ọnụnọ ke idem nwere ike ime ka e guzobere protein na-egosi ịdị irè ha.

tilorona umi-abawanye mgbe esịtidem eji protein ịta ruo mgbe a kacha uru ama mgbe 4 h. E nwere a jiri nwayọọ nwayọọ na guzobere interferon ke akpa eriri afọ, ndị na imeju na n'abalị - na ọbara.

Nkwadebe "TSikloferon" induces protein mgbe 4 awa, na a ọnụ ọgụgụ kasị elu a hụrụ mgbe 8 awa, mgbe nke na e nwere a jiri nwayọọ nwayọọ na ọnụ ke ịta.