"Moxifloxacin": ntuziaka maka ojiji, nkọwa, mejupụtara

The agwọ ọrịa "Moxifloxacin" pharmacological mmetụta nke nke ga-atụle dịrị gaba n'ime ebe, na-ezo aka na ìgwè nke quinolones. The ngwá ọrụ nwere a bactericidal, antibacterial mmetụta. Ọzọ, anyị na-atụle ihe kasị a na nkà mmụta ọgwụ "Moxifloxacin". Ntuziaka maka ojiji, analogues ga-ga-e gosiri na isiokwu.

mmetụta

Olee otú nọ n'ọrụ gị n'ụlọnga "Moxifloxacin"? Description nke ọgwụ ga na-amalite a nkọwa nke usoro nke ihe ndị ọ na bacteria. Bactericidal mmetụta pụtara metụtara na mgbochi (suppression) nke nje topoisomerase IV na II. Nke a, n'aka nke ya, na-eduga ná nsogbu na replication Filiks nke transcription, DNA idozi biosynthesis microbial mkpụrụ ndụ. N'ihi ya, na-abịa ha mbibi. Agwọ ọrịa "Moxifloxacin" ntụziaka ntuziaka na-akọwa dị ka a iche iche sara mbara ude.

eguzogide

Na antibacterial ọrụ nke ọgwụ ọjọọ "Moxifloxacin" adịghị emetụta usoro na akpasu iguzogide tetracyclines, macrolides, aminoglycosides, cephalosporins na penicillins. Ọ bụghị akara ọma na mmetụta nke cross-eguzogide. Ruo ugbu a, ikpe nke plasma kwụsie ike na-adịghị mata. Drug eguzogide "Moxifloxacin" na-emepe emepe nnọọ nwayọọ nwayọọ site na otutu mmụba.

nso nke ọrụ

Pụtara "Moxifloxacin (ntụziaka ntuziaka - àmà) emetụta ọtụtụ ụdị gram-nti na-gram-adịghị mma bacteria, acid-ngwa-ngwa bacteria, anaerobes, gbara gharịị microorganisms (mycoplasma, chlamydia, wdg), na-bacteria na-eguzogide ọgwụ dị macrolide na beta-lactam ogwu mgbochi ọgwụ ọjọọ eme ihe .

mmiri

Mgbe anata onu absorption nke ọgwụ "Moxifloxacin" ngwa ngwa na ihe fọrọ nke nta zuru ezu. Zuru oke bioavailability mgbe ndinọ intravenously na itinye ime ime - nke iji nke 91%. Mgbe ndinọ ọnụ (50-1200 mg dose, 600 mg / ụbọchị maka 10 ụbọchị) linear pharmacokinetics nke ọgwụ. The kacha ịta na 400 mg hụrụ mgbe 0.5-4 awa. Mgbe etinyere n'out oge na nri nweta na-abawanye na ndị oge mgbe Cmax (awa abụọ) na ya Mbelata site banyere 16%. Duration absorption ahụ na-adịgide na-agbanweghi agbanwe. O sina dị, ndị a data na-adịghị na-adakarị uru na-enye ohere na ojiji nke ọgwụ ọjọọ, "Moxifloxacin", n'agbanyeghị nke nri. Esonụ a otu igba ogwu n'akwara infusion nke 400 mg otu awa kacha ịta n'akparamagwa na njedebe nke infusion.

nkesa

N'ime ụbọchị atọ nke ngwa ruru ịha. Nkịtị na plasma-edozi - banyere 45%. Ọ na-ekwu pụtara ngwa ngwa nkesa nke ọgwụ ọjọọ, "Moxifloxacin" akụkụ na anụ ahụ. N'atu kasịnụ bụ na akpa ume anụ ahụ na bronchi mucous, akpụkpọ subcutaneous akụkụ, sinuses, mgbu foci. The asu na interstitial ọmụmụ agwọ ọrịa a hụrụ na unbound edozi, free ụdị. Ya ịta dị elu karịa na plasma. Ọnụ na a ọgwụ na-hụrụ na nnukwu ichekwa na akụkụ peritoneum nsụkọrọ nwanyị akụkụ na peritoneal ọmụmụ.

metabolism

Medicine "Moxifloxacin" (nkọwa nke ọgwụ na annotation data mejupụtara ozi) na-aga nke abụọ biotransformation adọ. Gbasara akụrụ excretion emejuputa usoro na eriri afọ unaltered n'ụdị sulpho ogige ma na-adịghị ejekwa glucuronide. The metabolites na-hụrụ na plasma. Ha ịta ala karịa na nke mbụ compound. Studies gosiri na ndị a umuihe ngwaahịa na-adịghị na-emetụta ihe ahụ.

Pụtara "Moxifloxacin", site na nke ọ kenyere?

The ọgwụ na-atụ aro maka nje mkpali pathologies okenye iwe na microorganisms enwe uche thereto. Karịsịa, agụ ịkọ otu exacerbation nke ala ala bronchitis eruba, nnukwu Sinusitis, obodo-enwetara oyi baa (kpatara ụdị nje bacteria na-egosi multiple eguzogide na t. H. The ọgwụ nje). Pụtara "Moxifloxacin" ntuziaka maka ojiji na-atụ aro maka na-efe efe nke rọrọ anụ ahụ na anụ ahụ, subcutaneous owuwu mgbagwoju anya ọnya (oria ọrịa ụkwụ nakwa), na intra-abdominal na-efe efe (polymorphic Filiks, intraperitoneal ahụ etuto na otú pụta). Na e kenyere mgbe agwọ ọrịa si streptococcus pneumoniae eguzogide multiple antibacterials, gụnyere ọnụnọ nke eguzogide ọgwụ penicillin, abụọ ma ọ bụ karịa dị iche iche nke ọgwụ ọjọọ eme ihe nke abụọ emana cephalosporins, macrolides, tetracyclines. Site na-egosi na-agụnye mkpali ọnya na pelvic akụkụ-adịghị mgbagwoju okike. Mgbe endometritis na salpingitis na-ume-atụle ihe n'aka (dị ka e gosiri site mmasị ka ọgwụ ọjọọ, "Moxifloxacin" ntuziaka maka ojiji). Eye tụlee kenyere nje conjunctivitis, iwe na microorganisms chebaara agwọ ọrịa. Ọ dịkwa mkpa ka gaa na akaụntụ ẹdude ọgwụgwọ nke na-efe efe pathologies edu.

Agwọ ọrịa "Moxifloxacin": na onunu ogwu na ụzọ nke ochichi

Ego ẹkedọhọde ime ime (ọnụ) na intravenously. . Duration ọgwụgwọ na agwọ ọrịa "Moxifloxacin", na onunu ogwu nke - 400 mg / ụbọchị, dabere na ụdị ọrịa na ya ogo, nakwa dị ka ndị hụrụ ọgwụgwọ mmetụta:

• Exacerbation nke-adịghị ala ala bronchitis N'ezie - 5-10 ụbọchị.
• Community-enwetara oyi baa - 7-14 ụbọchị zipụta ha n'usoro ọgwụ (igba ogwu n'akwara sochiri onu oriri).
• Adụ anụ ahụ, anụ ahụ (adịghị mgbagwoju), na nnukwu Sinusitis - 7 ụbọchị.
• Mgbe intra-abdominal na-efe efe (mgbagwoju anya) - 5-14 ụbọchị zipụta ha n'usoro ọgwụ.
• Mgbe mgbagwoju anya ọnya na subcutaneous owuwu nke anụ - 7-21 ụbọchị.
• Na mkpali pathologies nke pelvic akụkụ - 14 ụbọchị.

Maka ozi ọzọ, nwere mmasị ka ọgwụ ọjọọ, "Moxifloxacin" ntụziaka ntuziaka. Mbadamba ekwesịghị ikwe ka na-ata. -Asa ala na mmiri dị mkpa na a obere olu.

obodo were

Medicine "Moxifloxacin" (tụlee) nwere ike ndinọ ọrịa site na afọ. Practice na-egosi na mma-abịa n'ụbọchị nke ise. Mgbe na ị ga-anọgide na ọgwụgwọ ọzọ 2-3 ụbọchị. Ọrịa na-emetụta anya kụnyere a dobe ugboro atọ n'ụbọchị. Ọ bụrụ na e nweghị mmetụta maka ụbọchị ise ga-akpalite ajụjụ ndị correctness nke ọgwụ ma ọ bụ nchoputa. Na oge nke ọgwụgwọ na-adabere na bacteriological na-adakarị N'ezie na ogo nke daa ọrịa.

Ọzọkwa na maka infusion ngwọta

Agwọ ọrịa "Moxifloxacin" ntụziaka ntuziaka na-atụ aro na ị na-abanye otu awa. The ọgwụ na otú nwere ike ịbụ na undiluted ma ọ bụ na diluted ụdị. Ihe ngwọta bụ dakọtara na sodium chloride 0,9%, mmiri ogwu ogbugba, dextrose ngwọta na a ịta nke 10% na 40%, 20% xylitol, "ringer". Jiri naanị doro anya mmiri mmiri. Mgbe dilution nke agwọ ọrịa na-anọgide ufọk ufene maka ụbọchị na ụlọ okpomọkụ. Ghara-nọ na friji n'aka. Ọ bụrụ na ndị infusion a na-ndinọ na ndị ọrụ ọzọ, ọ bụla nke na-ndinọ iche iche.

mmetụta

N'ihi na ọgwụgwọ na ọgwụ "Moxifloxacin" eleghị ịzụlite fungal-efe efe, leukopenia, anaemia, thrombocytopenia. Mgbe ụfọdụ, ndị ọgwụ e nwere onye na-abawanye na prothrombin oge, thromboplastin kasịnụ ịgbanwe. Na ụfọdụ ndị ọrịa ọgwụ nwere ike ime ka nfụkasị Jeremaya mere, laryngeal edema, urticaria, anaphylactic ujo, pruritus, eosinophilia, ihe ọkụ ọkụ. Na obere okwu, e nwere hyperglycemia, hyperlipidemia, hyperuricemia. Na ọgwụgwọ nke puru omume ọrịa uche. Karịsịa, ọrịa nwere ike na-enwe hyperactivity, nchegbu, ịda mbà n'obi, depersonalization, ịmụ anya arọ nrọ, psychotic Jeremaya mere, Bilie echiche igbu onwe. Common mmetụta na-agụnye isi ọwụwa, dizziness, mara jijiji, iro ụra, mgbagwoju anya, uto uche ọrịa, ụra n'ọgba aghara, mgbagwoju anya. Mgbe ụfọdụ, n'oge ọgwụgwọ na ọgwụ nwere ike isi nchikota, ọdụdọ, Bilie dị iche iche na-adakarị ngosipụta, hypoesthesia, aghara nke ịnụ ísì. A ọnụ ọgụgụ ndị ọrịa nwere na-akawanye njọ nke okwu ọnụ, ntị, elu neuropathy, obi nchefu, polyneuropathy. Mgbe etinyere topically, ọhụụ nwere ike njọ ya ruo mgbe ọnwụ. Otú ọ dị, nke ikpeazụ a na-atụle ga-a na-akwụsị akwụsị ọnọdụ.

Mmetụta na obi usoro

Part nke mmetụta na ngwa nke ọgwụ "Moxifloxacin" bụ QT-nkeji prolongation na ọrịa na hypokalemia, palpitations, vasodilation, tachycardia. Na-adịghị ahụkebe mmetụta gụnyere ọbara mgbali na hypotension, ventricular tachyarrhythmias, syncope. Nnọọ adịkarịghị hụrụ gbasara obi njide. Adịgide ukwuu n'ime ahụkarị ndị mmadụ n'otu n'otu predisposed ka nnukwu ischemia, bradycardia (clinically ịrịba).

Mmetụta na ndị ọzọ na usoro na akụkụ

Mgbe ụfọdụ, ọgwụ nwere ike ime ka iku ume ọkụ ọkụ, gụnyere asthmatic ọnọdụ. A ọnụ ọgụgụ ndị ọrịa na-hụrụ ọrịa na digestive tract. Karịsịa, megide ndabere nke ọgwụgwọ-emergent ọgbụgbọ, vomiting, afọ ọsịsa, afo mgbu. Ole na ole mmetụta na-atụle ogbenye agụụ, dyspepsia, flatulence, gastroenteritis (ma e wezụga n'ihi erosive), afọ ntachi. Ụfọdụ ọrịa e kwuru na stomatitis, dysphagia, pseudomembranous afọ. The ọgwụ ga-eleghị anya ntọt ke transaminases, hepatic dysfunction, mmepe nke fulminant ịba ọcha n'anya, hepatic odida na-eduga na-eyi ndụ egwu. Nnọọ adịkarịghị hụrụ bullous cutaneous Jeremaya mere (nsí epidermal necrolysis, Stevens-Johnson syndrome). Ụfọdụ ọrịa nwetara myalgia, arthralgia, ụfụ, mụbara muscle ụda, tendonitis, muscle adịghị ike. akaị ruptures nwere ike ime na obere okwu, ogbu na nkwonkwo, gait nsogbu dị ka a n'ihi nke mmebi nke nweekwa usoro. Ọrịa na ọgwụgwọ na ọgwụ nwekwara ike ịdị na-eme ọgba aghara nke urinary usoro. Karịsịa, akara akpịrị ịkpọ nkụ (kpasue afọ ọsịsa ma ọ bụ ọnụ na mmiri mmiri olu iwesa), gbasara akụrụ dysfunction, insufficiency. Common mmetụta gụnyere sweating, nonspecific mgbu, malaise. Na igba ogwu n'akwara kwesiri thrombophlebitis ma ọ bụ phlebitis.

Onye na-adịghị kenyere n'aka?

Na nkà mmụta ọgwụ "Moxifloxacin" contraindications ndị dị ka ndị:

• Akaị daa ọrịa na akụkọ ihe mere eme na mepụtara ka a n'ihi nke ọgwụ quinolone ọgwụ nje otu.
• Nnweta elongate QT-nkeji (congenital ma ọ bụ enwetara).
• Electrolyte disturbances (karịsịa hypokalemia uncorrected).
• Bradycardia (clinically ịrịba).
• Heart odida na belatara ejection ọrụ ekpe ventricle.
• Imebi obi n'afọ iri na ụma (na akụkọ ihe mere eme).

Mgbe lactose ekweghị ibe nọrọ, glucose-galactose malabsorption, lactase erughi na-adịghị na-atụ aro agwọ ọrịa "Moxifloxacin" (ọgwụ mejupụtara mejupụtara lactose, ya mere pathologies kwuru na-gụnyere ke ndepụta). Ọ bụghị kenyere pụtara ime ma ọ bụ lactating. Mbadamba na ihe ngwọta e kwere ka ebe ọrịa afọ 18. Na-atụ aro iji ọgwụ bụrụ na nke hypersensitivity na mmiri.

pụrụ iche ikpe

Dị mkpa ịkpachapụ anya ná nhọpụta nke ọgwụ ndị ọrịa na Central ụjọ usoro abnormalities na predispose na mmepe nke ọdịdọ. Ihe ize ndụ na-agụnye ọrịa na proarrhythmic ekwu. A na-agụnye, akpan akpan, na-agụnye nnukwu ischemia, karịsịa n'ebe ndị agadi na ndị inyom. Ọzọkwa na-edebe ịkpachara anya na ọrịa na imeju imeju. onunu ogwu ukpụhọde nwere ike a chọrọ n'oge concurrent ọgwụ n'aka ẹsụhọde ịta nke potassium.

Maka ozi ọzọ,

Practice na-egosi na ọgwụ na-ọma na-anabata ọtụtụ ndị ọrịa. Ọkachamara na-nye iwu ndị na ngwá ọrụ na-efe efe ọnya. Nke a bụ n'ihi na eziokwu na ọgwụ nwere dịtụ elu arụmọrụ nke ọtụtụ bacteria. Otú ọ dị, e nwere mgbe ihe ize ndụ nke mmetụta, nke na-gụnyere na ngwaahịa adọ aka ná ntị "Moxifloxacin" ntụziaka ntuziaka. Analogs nke ọgwụ bụrụ na nke mkpa ga-bulie dọkịta n'otu n'otu. Dochie ngwá ọrụ nwere ike dị otú ahụ ọgwụ ọjọọ eme ihe dị ka: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" na ndị ọzọ. Mgbe mmetụta ọjọọ, a nkọ arịa ọrịa na omume nke mgbaàmà na-adịghị kọwara na nchịkọta, ị ga-achọ nlekọta ahụ ike ozugbo. Mgbe iji tụlee kwesịrị izere kọntaktị na oké ichekwa ọgwụ n'anya. Ọ bụrụ na nke a mere, ọ dị gị mkpa dị ka ngwa ngwa dị ka o kwere na ọtụtụ mmiri. Bụrụ na nke ovadozu nkwalite nke mmetụta.

Ná mmechi

Ọgwụ "Moxifloxacin" atụle zuru ezu nke nwere ike antibacterial. Na njikọ na nke a di ya na-adịghị na-atụ aro na-agbaji ndenye ọgwụ nke dọkịta. Karịsịa, ọ na-echebara echiche na ọnụ ọgụgụ na ugboro ole nke na ngwa n'aka. Ekwela gafere na usoro onunu ogwu. Igba ogwu n'akwara ọgwụ ga-rụrụ na a pụrụ iche na-amụ site a ruru eru mkpara so onye ga-enwe ike iji nyere aka ma ọ bụrụ na ọ dị mkpa. Ị ga bụghị onwe-medicate. Na enweghị ihe ọgwụ dị mkpa ịhụ dọkịta. Dị tupu iji ọgwụ "Moxifloxacin" ga-akpachara anya na-agụ ntụziaka.