"Clopidogrel": analogues, ojiji, ntuziaka, price

Mgbe ụfọdụ, ndị dọkịta idepụta ọgwụ "Clopidogrel"? Ntuziaka maka ojiji, analogs, ntọhapụ ụdị, mejupụtara, mmetụta na-egosi maka ojiji nke a na nkà mmụta ọgwụ ga-ọkọnọ zuru ezu na a n'isiokwu a. Ke adianade do, ị ga-amụta uru nke ọgwụ na ndị ọrịa uche banyere ya.

Hapụ ụdị na mejupụtara

ị pụrụ ịzụta ọgwụ "Clopidogrel" Olee ụdị? Guide na-akọ na ọgwụ a tọhapụrụ n'ụdị mbadamba, nke na-ntekwasa na a film mkpuchi. Na otu ọnya nwere 14 iberibe, na akụ - 14 ma ọ bụ 28, na a katọn ùkwù - 1 ma ọ bụ 2 efere na ọgwụ. Isi nọ n'ọrụ mgwa ihe bụ clopidogrel na hydrogen sulphate ụdị. The inyeaka mmiri dị na ọgwụ Nwa-agụnye anhydrous lactose, magnesium stearate, pregelatinized starch, hydrogenated Castor mmanụ, polyethylene glycol 6000 na microcrystalline cellulose. Film mkpuchi, nke ntekwasa mbadamba esịnede titanium dioxide, hypromellose, aluminum lacquer (dabeere na e ji esiji ákwà Ponceau 4 R), na polyethylene glycol 400 na 6000 emejuputa agwọ ọrịa 'Clopidogrel' (price ga-egosi n'okpuru) via a yinye drugstores, ma naanị na ọnụnọ nke ọgwụ.

pharmacological e ji mara

Na ọgwụ ọgwụgwọ, belata platelet aggregation rata ndị ọzọ agonists. Ime ọgwụ "Clopidogrel" (ntuziaka maka ojiji, price, reviews, na nza nke ọzọ ihe ọmụma bara uru dị na ọtụtụ ọgwụ na ahụ ike weebụsaịtị na ọkọnọ a akwụkwọ) maka awa abụọ, kacha arụmọrụ akaụntụ maka 4-7 ụbọchị n'okpuru ọnọdụ nke mbanye 50-100 mg kwa ụbọchị. Antiplatelet mmetụta dịruru n'etiti ụbọchị 7 ruo 10 ofụri oge nke platelet ndụ.

Pharmacokinetics

Mgbe onu ochichi nke ọgwụ ọjọọ, "Clopidogrel" (75 mg - ọkọlọtọ dose) na-ngwa ngwa etinye obi gị dum na eriri afọ tract, na ịta na mmiri mmiri òkè nke ọbara na-ụba ubé, ma mgbe 2 awa na esịmde larịị nke nwere ike kpebisie (0.025 g / L).

Ọ na-ukwuu metabolized site imeju. The isi metabolite bụ-adịghị ejekwa ozi emepụta nke a carboxylic acid (ihe dị ka 85% na-amalite ihe onwunwe na-ekesa na plasma). The nkezi kacha ịta mgbe ugboro ugboro eji "clopidogrel" bụ 3 mg / l, ọ pụrụ hụrụ otu awa mgbe ingestion.

Active umi na metabolite irreversibly ewee plasma-edozi. Communication anọgide insatiable.

Mgbe onu ochichi nke 14C-kpọrọ "clopidogrel" fọrọ nke nta ọkara nke dose-egosi na urination, banyere 46% - na faeces n'elu 120 awa. T1 / 2 nke isi metabolite - 8 awa.

Saturation metabolite ọtụtụ ugboro ndị ọrịa mgbe na-eru afọ 75 nke afọ, a na-adịghị agbanwe agbanwe platelet aggregation na-agba ọbara oge.

The ọbara plasma na oké akụrụ ịta nke metabolite bụ site 5 na 15 ml / min, ma mgbe nkezi ọrịa ogo ọ bụ 30-60. N'agbanyeghị eziokwu na ndị inhibitory mmetụta ọrịa na adenosine diphosphate - rata platelet aggregation ahụ belatara, ọ na ụba na-agba ọbara oge, nakwa dị ka na ike ọrụ afọ ofufo.

na-agba akaebe

Ị maara, n'ihi na nke nzube dọkịta kenyere a ọgwụ ọrịa dị ka "Clopidogrel"? Analogs, na o mere a agwọ ọrịa maka mgbochi nke thrombotic nsogbu nke ischemic ọrịa strok, myocardial infarction na elu ọbara occlusive ọrịa. Imekotaotuugbo ọgwụgwọ na acetylsalicylic acid na "clopidogrel" dị ka e gosiri na mgbochi nke thrombotic nsogbu, nke na-a na-akpata nnukwu akwara syndrome.

contraindications

'Clopidogrel' (price na pharmacies Moscow region bụ banyere 510 rubles) itinye counter na:

• hypersensitivity;
• nnukwu ọbara ọgbụgba;
• haemorrhagic syndrome ;
• oké hepatic impairment;
• ẹyenọ intracranial daa ọrịa na predisposing na mmepe nke ọbara ọgbụgba (akpa ume akpụ, exacerbation nke peptic ọnyá afọ, hyperfibrinolysis, ụkwara nta);
• lactose erughi (n'ihi na onunu ogwu forms nwere mmiri ara ehi sugar), butere n'aka galactose ekweghị ibe nọrọ, malabsorption syndrome glucose-galactose.

"Clopidogrel": n'iji na onunu ogwu

The mbadamba dị ka ntụziaka, e nwere ike iwere n'agbanyeghị nri. N'ihi mgbochi nke thrombotic ihe na ọrịa na ischemic ọrịa strok ma ọ bụ myocardial infarction, ndị dọkịta ji nye iwu ka ụbọchị ọ bụla "Clopidogrel" 75 mg. Na nnukwu ọrịa, nke e mere site mmepe nke Baịbụl hiwere isi n'ebe ischemic necrosis nke obi muscle, ọgwụgwọ a ga-malitere site n'ụbọchị ndị mbụ. ọgwụ na iji "Clopidogrel" - dịghị ihe karịrị 35 ụbọchị. Ọrịa na ischemic strok nwere ike buru nke a na nkà mmụta ọgwụ ruo ọnwa isii. Mgbe thrombotic nsogbu ịda n'etiti ACS enweghị eweli na ST nke, ọgwụgwọ na-butere na-anata disposable loading dose (300 mg), na n'ihu adịghị ewe ihe karịrị otu mbadamba kwa ụbọchị. Oke arụmọrụ a hụrụ mgbe ọnwa atọ. Na oge nke ọgwụ na 'Clopidogrel' (analogs na generics ọkọnọ n'okpuru) ekwesịghị gafere otu afọ. Against ndabere nke nnukwu akwara syndrome na ST nke elu mgbe kenyere 75 mg nke ọgwụ na a kwa ụbọchị na mbụ otu oge ojiji nke a loading onunu ogwu na Nchikota na thrombolytic elekọta mmadụ na acetylsalicylic acid. Ozugbo mgbaàmà na-egosi, i kwesịrị gaa Nchikota ọgwụ. Ọrịa karịrị afọ 75 nke ọgwụgwọ na-enweghị a loading dose.

ovadozu

On na-anata ọgwụ na doses uku na-atụ aro, ọ pụtara ìhè site na-abawanye na-agba ọbara oge na ụdi nsogbu. N'ọnọdụ ndị dị otú ahụ, ị ga-mkpa ọgwụgwọ kwesịrị ekwesị. Na ikpe mgbe ị kwesịrị a ngwa ngwa mgbazi nke ruo ogologo oge ọbara ọgbụgba, i kwesịrị a mịnye nke TM. E nweghị kpọmkwem ngwọta.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

Imekotaotuugbo n'ikuku nke "clopidogrel" na warfarin arụpụta na-abawanye na-agba ọbara ọnụego, nke bụ ya mere nke a Nchikota bụ ukwuu ekwesighi. Ọ na-enwekwu ohere nke ọbara na-agba na ọgwụgwọ nke a ọgwụ na Nchikota na ndị so ná ndị mgbochi mkpali ọgwụ ọjọọ, aspirin, glycoprotein inhibitors na heparin.

mmetụta

Ọgwụgwọ agwọ ọrịa 'Clopidogrel' (ọrụ, na price, na usoro nke ochichi na onunu ogwu na-kọwara n'ụzọ zuru ezu na ihe a) nwere ike ime ka ekwesighi pụta:

• Blood coagulation usoro: n'oge ọnwa mbụ nke ọgwụ na-na-ebilite hemorrhage, hematomas apụta; dịkarịa ala - conjunctive hemorrhage; dịpụrụ adịpụ ikpe - intracranial ọbara ọgbụgba.
• hematopoietic usoro: na obere okwu - thrombotic thrombocytopenic purpura, granulocytopenia, anaemia, gụnyere pancytopenia, na aplastic anaemia.
• Ụjọ usoro: mgbe ụfọdụ apụta isi ọwụwa, paresthesia, dizziness; obere - vertigo; dịpụrụ adịpụ ikpe - uche mgbasasị na ịmụ anya arọ nrọ.
• Ọbara arịa na obi, ọtụtụ mgbe, na-guzobere hematoma; mgbe ụfọdụ nwere oké hemorrhage, vasculitis, zie ọbara mgbali.
• Akụkụ okuku ume na usoro: epistaxis, bronchospasm, akpa ume hemorrhage, interstitial pneumonitis, hemoptysis.
• Digestive tract: afọ ọsịsa, dyspepsia, abdominal mgbu, na-agba ọbara si digestive tract, mgbu na gastric ọnyá afọ, vomiting, flatulence, ọgbụgbọ, afọ ntachi, retroperitoneal agba ọbara, afọ, pancreatitis, stomatitis, nnukwu mmebi imeju, ịba ọcha n'anya, mụbara imeju enzymes.
• Nweekwa usoro: arthralgia, myalgia, ogbu na nkwonkwo.
• Skin: bullous rashes (Stevens-Johnson syndrome na-egbu egbu epidermal necrolysis, erythema multiforme), eczema, erythematous ọkụ ọkụ, na lichen planus.
• Urinary System: hematuria, hypercreatininemia, glomerulonephritis.
• Nfụkasị Jeremaya: angioneurotic edema, ọbara ọrịa, urticaria, pseudoallergy mmeghachi omume.

Mgbe ọgwụ na a ọgwụ fever na-adịkarịghị hụrụ, nke na-adịghị aghọta ka a N'ihi nke na-anata agwọ ọrịa, na dị ka a mgbaàmà nke nkịtị oyi.

adọ aka ná ntị

Medicine "Clopidogrel" ihe ókè ịkpachara anya mgbe na-ewere elu puru nke na-agba ọbara n'ihi nke ịwa ahụ adọ, hemostatic ọrịa. Ọ bụrụ na ịwa ahụ dị mkpa, na antiplatelet mmetụta dị ukwuu ekwesighi si ochichi nke ọgwụ ga-tụfuo maka izu tupu oge a kara aka nke ịwa ahụ. Akpan akpan elekọta na nkà mmụta ọgwụ kenyere oké imebi nke imeju ọrụ, nke nwere ike ime ka hemorrhagic diathesis. Ọ bụrụ na ihe ịrịba ama nke oké ọbara ọgbụgba mkpa ịmụ hemostatic usoro. Ke adianade do, ọ dị mkpa ka mgbe niile nyochaa arụmọrụ nke ọtọ ọrụ nke imeju. Ịkpachara anya "Clopidogrel" na-eji na heparin, NSAIDs, warfarin. Mgbe eduzi ibuo ọmụmụ hụrụ dịghị carcinogenic na genotoxic mmetụta nke ọgwụ, ke adianade do, na-adịghị ka ndị mmetụta na okporo ụzọ management ikike.

"Clopidogrel": analogs na generics

Synonyms (analogs) ọgwụ - a na nkà mmụta ọgwụ ndị nwere otu ihe ma ọ bụ ndị nwere otu mejupụtara. Gịnị ọgwụ ike dochie nkà mmụta ọgwụ "Clopidogrel"? Analogs nkwadebe nke nọ n'ọrụ umi na-esonụ: "Kardutol", "Detromb", "Agregal", "Trombeks", "Klopilet" "Trocken", "Plavix", "Plagril", "Plogrel", "Targetek", "Egitromb" "Clopidogrel Teva,".

Onye ọ bụla ọgwụ nwere dị iche iche e ji mara, otú ahụ were na-kwere na mgbe oge na dọkịta gị.

Echiche banyere nkà mmụta ọgwụ

Ihe ndị mmadụ na-ekwu banyere ndị dị otú ahụ nkwadebe dị ka "Clopidogrel"? Nyocha nke ọrịa ndị nwere ohere nyefee oké ọrịa na ịwa ahụ adọ bụ oké mma. Ọrịa na-akọ elu oru oma edinam nke agwọ ọrịa, ọ bụ o abụghị maka n'ikuku na iji onwe-ọgwụ. Analogues nke ọgwụ ọjọọ na-enyere ndị ọrịa na-ahọrọ ndị kasị mma nhọrọ maka ha na ruru nke price na àgwà, ma nzube na irè nke akara ga-nyere na-ahụmahụ ọkachamara.