Congenital adrenal hyperplasia

Congenital adrenal hyperplasia - a kama obere na naanị a butere n'aka ọrịa, nke a na-esonyere mmiri ọgwụ ahaghị nhata cortisone na aldosterone - adrenal homonụ. Congenital adrenal hyperplasia, dị ka a na-achị, nwere ike kpebisie ọbụna n'oge nwa ebu n'afọ na mmepe ma ọ bụ ná mmalite nke nwa ọhụrụ ndụ.

Ọrịa a na-egosipụta site na otu ezughi oke ọnụ ọgụgụ nke enzymes maka njikọ nke cortisol. Dị ka a n'ihi nke iju ke ahụ nke a hormone na-amalite iji rụọ ọrụ hypothalamic-pituitary njikọ, n'ihi-ebuwanye ibu nke ebe nke glands na-ahụ maka ndị njikọ na secretion nke androgens.

Congenital adrenal hyperplasia: o ketara eketa

N'ezie, mutated site n'usoro abụghị isi, nke pụtara na ọ na-ebute site ná ndị ezinụlọ site ọtụtụ ọgbọ. Ka ihe atụ, ọ bụrụ na a mụrụ nwata na ọrịa, ma nne ma nna na-ebu ihe ndị mutated site n'usoro, na ha onwe ha adịghị arịa ọrịa. Ma nne nne ma ọ bụ nna na nne nke nwa nna nna, kwa, ahụhụ si na adrenal syndrome.

Congenital adrenal hyperplasia: mgbaàmà na-adakarị ngosipụta

Dị ka ekwuola, ọrịa na-esonyere na-abawanye na androgens - homonụ na welie development na ime ihe nke omumu usoro.

Congenital adrenal hyperplasia na ụmụ agbọghọ na-egosipụta ozugbo nwa, dị ka mpụga kenwe na-oke ike mepụtara. Ka ihe atụ, nwanyi ji anyu mmamiri bụ nnukwu, na na ụzọ ụfọdụ yiri a amụ, mgbe ndị tojuru elu labia yiri scrotum.

Ke edinam na ọnụnọ nke ọrịa ahụghị tupu orùrù si n'ụlọ ọgwụ, mgbe e mesịrị na-amalite a nnọọ ngwa ngwa mmekọahụ development. Ruo ọtụtụ izu mgbe a mụrụ na ụmụ agbọghọ pubic ntutu uto pụtara, na mgbe ahụ ndị ọzọ niile na akụkụ ahụ, nwoke ụkpụrụ. Nke a pụtara na nwa agbọghọ ntutu na-etolite na ihu. Na n'ihu mmepe nke ọrịa na ọ bụ omume na-ekwu okwu banyere otu ụdị nke nwanyi hermaphroditism. Ke adianade do, mammary glands na ụmụ agbọghọ ndị a adịghị ịzụlite, nanso anaghị na-amalite, ọ bụ ezie na akpanwa na ovaries-eto nke na dị ka afọ nke nwa.

Adrenogenital ụmụ nwoke syndrome nwere dịghị-egbuke egbuke ịrịba ama ozugbo mgbe amuchara nwa. Ma mgbe a izu ole na ole, Ichi a ọkpụrụkpụ na-abawanye nke na amụ - hà ọ na-adịghị-ederịta akwụkwọ ozi afọ. N'otu oge ahụ, na testicles ịzụlite kwesịrị, dị ka ọ bụla ike nwa ọhụrụ.

Ụmụaka ndị a nwere ihe ụfọdụ na-atụmatụ nke development. Ihe atụ, ha ngwa ngwa na-eto eto na tozuru okè. Ma uto mpaghara na-emechi ngwa ngwa, na otú ndị mmadụ na-stunted. Ke adianade do, ha na-akwanyere ya ùgwù site a ala, o siri ike olu, ma ụmụ agbọghọ na ụmụ nwoke.

A ọzọ oké ụdị ọrịa a na-hụrụ mebiri nke nnu metabolism, mụbara ọbara mgbali.

Adrenogenital syndrome na ụzọ nke ọgwụgwọ

Ọ bụ uru na-arịba ama na ihe ịga nke ọgwụgwọ na-adabere n'ụzọ dị ukwuu na otú ngwa ngwa ọ na-amalite. Tupu a mkpụrụ ndụ ihe nketa na ọrịa abụghị amenable ọ bụla ọgwụgwọ, ma na mgbe usoro nke ya mmepe e kọwara, doro anya na usoro ọgwụgwọ.

Ọrịa ndị mmadụ mkpa cortisol, nke na-egbochi ọrụ nke pituitary na hypothalamus, na, mmọdo, na ibelata androgens ke iyịp. N'ezie, n'ikuku nke cortisol mkpa ná ndụ mmadụ.

Ke adianade do, na ikpe nke na mbubreyo nchọpụta nke ọrịa na ụmụ agbọghọ mkpa mgbe ụfọdụ plastic ịwa ahụ na mpụga kenwe, n'oge nke nwanyi ji anyu mmamiri na-egbutu gbanwee na udi ma na size nke labia. Na kwesịrị ekwesị na mgbe omume maka inyom dị otú ahụ bụ na o kwere omume, ọbụna a nkịtị ime.

Ọ bụrụ na adrenogenital syndrome na-esonyere ọrịa nke secretory usoro, mkpa ozugbo ọgwụgwọ kwesịrị ekwesị.