"Cymbalta": ntuziaka maka ojiji. Nyocha, ahịa, na-egosi

Taa, anyị ga-agwa gị na bụ ọgwụ "Cymbalta." Ntuziaka maka ojiji nke ọgwụ, ya mejupụtara, mmetụta, na ịgụ ga-kọwara n'okpuru ebe a. Ọzọkwa si osụk edide, ị ga-amụta banyere ụdị nke na ọgwụ dị, ole ọ na-eri, ma o nwere a contraindication na esi etinye ya n'ụzọ ziri ezi.

ntọhapụ Ụdị

Na ihe n'ụdị na ọ nwere ike ịzụta ọgwụ "Cymbalta" ntụziaka nke a na-nchọ na ngwugwu? Ugbu ọgwụ na-na tọhapụrụ n'ụdị enteric capsules. Onye ọ bụla n'ime nke nwere pellets, nke nwere a na-acha ọcha ma ọ bụ grayish acha ọcha na agba.

ọgwụ

Gịnị mmiri na-agụnye ọgwụ "Cymbalta?" Ntuziaka maka ojiji nke capsules na-ekwu na ha isi ifịk mmewere bụ a umi duloxetine. Ọ kwesịkwara kwuru na Ọdịdị nke ahụ na-ewere agwọ ọrịa ma na-agụnye ndị ọzọ bekee ka sucrose, hypromellose, talc, succinate, ọcha colorant, hypromellose acetate, titanium dioxide, triethyl citrate, gelatin, sodium lauryl sulfate odo ígwè oxide ink.

Capsules nwere ike ịnwe 60 na 30 mg ọgwụ. Ha na-juru n'ọnụ na blisters nke 14 ma ọ bụ 7 capsules. Na otu katọn mkpọ nwere ike ịbụ 1, 2 ma ọ bụ 6 blisters.

Pharmacological e ji mara nke ọgwụ

Gịnị bụ n'ọrụ umi dị ka duloxetine? Ntuziaka maka ojiji nke ọgwụ capsules na-ekwu na ndị dị otú ahụ a ọgwụ eme na kwuru mmewere bụ nnọọ ezi antidepressant. Ọ bụ ihe na inhibitor nke reuptake nke nọrepinefrini na serotonin. Ọ weakly egbochi dopamine uptake na ọ dịghị mmekọrita na dopamine, histamine, na adrenergic anabata holino-.

Olee otú Duloxetine? Guide nwere ndị na-esonụ ihe ọmụma n'isiokwu a: ụkpụrụ nke ihe nke umi bụ ibelata reuptake nke nọrepinefrini na serotonin. N'ihi ya, budata enwekwu noradrenergic na serotonergic neurotransmission na ụjọ usoro. Ọ kwesịkwara kwuru na duloxetine ngwa ngwa ebelata ihe mgbu.

Pharmacokinetics nke ọgwụ

Formulations nke ịda mbà n'obi nke "Cymbalta" etinye obi gị dum na eriri afọ tract, absorption amalite a awa ole na ole mgbe ochichi. The kacha ịta na-enweta mgbe 6 awa. Imekotaotuugbo n'ikuku nke nri adịghị emetụta ịta na enwekwu oge iji nweta a 6 10 awa. Ọkachamara na-ekwu na ọ na n'ụzọ na-ebelata ókè nke absorption (11%).

Nkịtị nke ọgwụ na plasma-edozi dị elu zuru ezu na esịmde ihe karịrị 90%.

The ọkara ndụ nke ọgwụ bụ awa 12. N'otu oge ahụ ọ na-aga ke mmamịrị ka metabolites.

Dị ka ọmụmụ, e nwere ọdịiche dị n'etiti ndị pharmacokinetic Filiks na-erukwa na ndị inyom na ndị ikom. N'ihi ya, nkezi nwechapụ nke nọ n'ọrụ mgwa n'okpuru fairer mmekọahụ. Otú ọ dị, dose ukpụhọde adịghị mkpa.

Ọ kwesịkwara kwuru na iche n'etiti pharmacokinetic Filiks na-erukwa na ndị agadi na katatụrụ ọrịa e n'oge nchọpụta. Ọ kpughere na ọkara ndụ nke ọgwụ dị elu na ndị agadi karịa na-eto eto. Ọ dịghị onunu ogwu ukpụhọde bụ chọrọ ma.

Na ọrịa na-adịghị ala ala gbasara akụrụ insufficiency na ọnụ ogbo, bụ ndị na dialysis, ịta nke arụmọrụ ma AUC nke duloxetine abawanye na kpọmkwem 2 ugboro. Ọ bụ ya mere na ọ na-atụ aro ka a tụlee advisability nke mbenata na onunu ogwu nke ọgwụ na ọrịa na oké impairment nke gbasara akụrụ ọrụ.

Ọrịa na mgbaàmà nke imeju ọdịda nwere ike jiri metabolism na mmechi ọkara ndụ nke duloxetine.

Egosi maka ojiji nke ego

Mgbe prescribers "Cymbalta?" Ntuziaka maka ojiji na-agụnye ndị na-esonụ ndepụta agụ:

• ọrịa neuropathy mgbu udi;
• ịda mbà n'obi na obi dara ya mbà na-ekwu;
• generalized nchegbu aghara;
• adịghị ala ala mgbu nweekwa syndrome, gụnyere ndị mere site fibromyalgia na osteoarthritis.

Contraindications ojiji nke ego

Mgbe ị na-apụghị iri ọgwụ "Cymbalta?" Ntuziaka maka ojiji na-agụnye ndị na-esonụ ndepụta contraindications:

• imekotaotuugbo ngwa nke nwere ike inhibitors nke isoenzyme CYP1A2 (e.g., enoxacin, ciprofloxacin ma ọ bụ fluvoxamine);
• Mụbara uche na-enwe ndidi pụtara mmiri;
• ụmụ n'okpuru afọ 18;
• a-adịru nwa oge n'ikuku na Mao inhibitors;
• Ọbara mgbali elu bụ n'echeghị echiche;
• uncompensated mmechi glaucoma;
• oké ala ala gbasara akụrụ odida (na CC na-erughị 30 ml / min);
• isomaltase erughi ma ọ bụ saccharase, glucose-galactose malabsorption na fructose ekweghị ibe nọrọ;
• imeju ọrịa na-ebu hepatic insufficiency.

Mgbe a ga-eji na-ekwesịghị ọgwụ

Ọ ga-eji nlezianya si ọgwụ na imetụ mmadụ n'isi na Mania, ụfụ n'ihe ize ndụ n'ihi agha n'akuku-mmechi glaucoma. Ọzọkwa, na-elekọta ga-a mgbe ocular ọbara mgbali elu, na-egbu onwe echiche, hyponatremia, imeju na-na akụrụ.

Drug "Cymbalta": ntuziaka maka ojiji

The price nke ngwaahịa a bụ nnọọ elu. Otú ọ dị, ya irè bụ n'okpuru obi abụọ ọ bụla.

Ọkọnọ ọgwụ kenyere naanị maka onu ochichi. The capsules ga-elo dum enweghị ndinuak ma ọ bụ ịta ha. Ọ ga-kwuru na ihe ọ bụla ikpe enweghị ike-atụkwasịkwara ọgwụ ma ọ bụ nri mix ya na ihe ọ bụla oke mmiri, ebe ọ bụ na ndị dị otú ahụ edinam pụrụ n'ụzọ dị mfe ibutere enteric mkpuchi.

Formulations nke ịda mbà n'obi kwesịrị iwere na mbụ onunu ogwu nke 60 mg otu ugboro n'ụbọchị. Iji nweta ezi ihe na ụfọdụ ndị ọrịa na-amụba kwuru ego ka a kacha dose of 120 mg ugboro abụọ n'ụbọchị.

Ọrịa chọpụtara na-adịghị ala ala gbasara akụrụ odida, nke pụtara na ọnụ ogbo, mbụ onunu ogwu nke agwọ ọrịa bụ 30 mg otu ugboro n'ụbọchị. Ọ bụrụ na ọrịa nwere imeju malfunction, ndị gosiri ego nke ọgwụ na-atụ aro ka belata ma ọ bụ belata multiplicity n'ikuku.

Ọ kwesịkwara kwuru na zere mberede ndọrọ ego na-anata agwọ ọrịa. The ego nke ọgwụ dị mkpa iji belata nwayọọ nwayọọ n'elu 1-2 izu. Ọ bụrụ na a zụlite ha, e nwere akpọ ịrịba ama nke syndrome, ọ na-atụ aro na-agwọ na ẹkedọhọde onunu ogwu. Mgbe e mesịrị, dọkịta nwere ike ịnọgide na ibelata dose, ma ihe nwayọọ nwayọọ.

ikpe nke ovadozu

Gịnị ọkachamara na-ekwu banyere ọgwụ ovadozu mgbe, "Cymbalta?" Nyocha nke dọkịta nwere ozi na ndị dị otú data dị ka ha. Ka ụbọchị, e nwere otu nke ovadozu site ingestion nke ọgwụ na ichekwa ruo 3000 mg, ma mgbe ọ na jikọtara ndị ọzọ mmadụ. Itunanya bu na, ofu na otu ọnwụ.

Ịrịba ama nke ovadozu ma ọ bụ ndị dịpụrụ adịpụ jikọtara na-agụnye ndị na-esonụ ọnọdụ: clonic ụfụ, somnolence, vomiting, Coma, serotonin syndrome na tachycardia. Ma preclinical nnyocha (nwere na ụmụ anụmanụ), isi mgbaàmà nke toxicity metụtara na-achịkwaghị achịkwa na ndibọbọ agwọ ọrịa, bụ ọrịa nke Central ụjọ na digestive usoro. Ọzọkwa, ọrịa nwere ike na-egosi tremor, ataxia, clonic ụfụ, vomiting na ọnwụ nke agụụ.

Gịnị na-eme bụrụ na ndị ovadozu? Na mmepe nke serotonin syndrome ga-ozugbo rụrụ edozi ọgwụ cyproheptadine, nakwa dị ka ụzọ mee ka normalize onye ọrịa ahụ ahu okpomọkụ.

Onye ọrịa a chọrọ inye ọhụrụ ikuku. Ị ga-nyochaa ọrụ nke obi na nyochaa mkpa ịrịba ama. All a ga-eme na njikọ na nketa nkwado na symptomatic ọgwụgwọ.

Ọ bụrụ na mgbe ochichi nke ọgwụ bụ ogologo oge, ọ dị mkpa na-asa na-afo. Ọzọkwa, iji na-amachi oriri nke ọgwụ ọrịa na-jụrụ na-aṅụ na-arụ ọrụ unyi.

n'akụkụ mmetụta

Nwere ike a na-adịghị mma mmetụta na ụmụ mmadụ ike nke ẹkenọde kwuru ọgwụ? Tụlee mmetụta nke antidepressant ọgwụ ọjọọ na ndị ọzọ zuru ezu:

• Ọtụtụ mgbe (na 10% nke ikpe) na Clinical ọmụmụ, ọrịa ndị na-esonụ na-ekwu: dizziness, isi ọwụwa, akọrọ ọnụ, ehighị ụra nke ọma, ehighi ura, ọgbụgbọ, iro ụra na afọ ntachi.
• Naa ngụkọta (1 ruo 10% nke ikpe) ọrịa na-hụrụ flushing, afọ ọsịsa, bịara ikiri ọhụụ, vomiting, sweating, tremor, mụbara anorgasmia, ebelata agụụ, ọnwụ nke libido, arọ ọnwụ, ike ọgwụgwụ, erectile dysfunction, na-egbu oge ma ọ bụ ọrịa ntutu ịdapụsị ejaculation.

Anyị nwere ike ikwu na ndị dị otú ahụ mmetụta dị ka dizziness (mgbe ụfọdụ isi ọwụwa na ọgbụgbọ), mgbe hụrụ na mberede kagbuo a agwọ ọrịa. Site n'ụzọ, na ọrịa na-egbu mgbu ọrịa neuropathy forms nwere ike na-abawanye na ọbara glucose na ihe efu afo.

Nyocha nke agwọ ọrịa

Dị ka ọkachamara, na ndị ọrịa na-ewere ọgwụ n'ụzọ zuru ezu ịnagide ọrụ. Mgbe ọ natara ya eliminates ihe nchegbu aghara, nakwa dị ka na-akwalite ofufe nke dara ya mbà na-ekwu. Ke adianade do, ifịk agwọ ọrịa ọma aka mgbu ọrịamkpokọta na nweekwa usoro.

Mmekọrịta ọzọ n'aka

Ọ kwere omume-ngalaba-ochichi nke ọgwụ ọjọọ ndị ọzọ na ọgwụ "Cymbalta?" Ọbịa ọkachamara na-ekwu na kwuru n'aka bụ kpọmkwem mmetụta na irè nke ọgwụ ụfọdụ.

Ya mere, e nwere ihe ize ndụ nke serotonin syndrome, duloxetine ma ọ bụrụ na-eji na Nchikota na MAOIs.

N'ihi CYP1A2 isoenzyme na-ifịk ke metabolism nke "Cymbalta 'nkwadebe, ha imekotaotuugbo were pụrụ iduga ụba kasịnụ nke ikpeazụ.

Ọ bụghị na-atụ aro maka kwuru agwọ ọrịa na ndị ọzọ na ọgwụ ọjọọ na-emetụta Central ụjọ usoro. Ọzọkwa, n'oge ya mbanye kwesịghị ịṅụ mmanya.

Mgbe ụfọdụ, mgbe ojiji nke SSRIs na serotonergic mmadụ na ọrịa hụrụ serotonin syndrome. Ya mere, ị ga-egosipụta oké ịkpachara anya mgbe eji a ọgwụ na serotonergic antidepressants.

N'ihi na eziokwu na e nwere a nwere ize ndụ dị elu nke ọbara ọgbụgba ekwesịghị iji ma duloxetine na anticoagulants (antithrombotics).

Ara na ime

Enwere m ike iji ọgwụ "Cymbalta", ego nke nke ga-ọkọnọ on, n'oge ime? N'ihi na enweghị nke zuru ezu ozi, na ojiji nke umi duloxetine n'oge gestation ọgwụ ike ga-ndinọ naanị ma ọ bụrụ na uru na nwanyị nnọọ elu karịa ihe ize ndụ maka nwa ọhụrụ.

Ọ kwesịkwara kwuru na ọrịa na-ewere nke a gị n'ụlọnga kwesịrị ijide n'aka iji gwa dọkịta gị banyere omume ma ọ bụ na-eme atụmatụ a ime.

Studies gosiri na ndị inyom na-ewere antidepressants na steeti, karịsịa na mgbe e mesịrị nkebi, na-eme nnọọ ihe ize ndụ nke persistent akpa ume ọbara mgbali nke ụmụ ọhụrụ. Na nke a, na syndrome nwekwara ugboro ugboro hụrụ na ụmụ bụrụ na nke a na mberede na-akwụsị iji duloxetine n'ọdịnihu nne na a mbubreyo ogbo nke ime. Ọtụtụ n'ime ihe mgbaàmà nke a ọnọdụ chọpụtara n'oge nnyefe ma ọ bụ na ndị mbụ mgbe.

N'ihi duloxetine bụ ike banye n'ime mmiri ara, ọ bụghị na-achọsi ike ka breastfeed nwa gị n'oge ọgwụ. Ma ọ bụghị ya, ịta nke umi ke nwa ebu n'afọ ga-ga na-ego nke 0,14% nke ịta na nne.

Specific nduzi na ojiji nke ọgwụ

Site n'ikenye ọgwụ ka ya ndidi "Cymbalta", dọkịta na iwu ji na-agwa ya na haa machibidoro a otu oge nnabata nke gị n'ụlọnga na Mao inhibitors. Ma ọ bụghị ya, o nwere ike na-eyi egwu na-egbu egbu, na oké njọ nsogbu nke hyperthermia, myoclonus na owụt excitation mgbanwe n'ime a amaghị onwe ya.

Ọ kwesịkwara kwuru na a machibidoro iwu na-enweta si ọgwụ maka izu abụọ mgbe ọgwụgwọ Mao inhibitors.

Dị ka ọmụmụ, na ọrịa na manic ala mgbe eji ọgwụ ọjọọ ndị ọzọ na-emetụta ndị ụjọ usoro, na njikọ na pụtara "Cymbalta" nwere ike njọ ẹdude ọrịa.

N'ihi na eziokwu na na dara ya mbà na-ekwu na e nwere a likelihood nke igbu onwe, kwesịrị karịsịa nyochaa ọrịa nke ihe ize ndụ otu.

Ịnakwere ọgwụ pụrụ ịbụ nnọọ mfe ime ka iro ụra. Ya mere, ọrịa ndị na-ewere a ọgwụ, ị ga-mmezi elekọta mgbe ụgbọala na mgbe na-arụ ọrụ dị ize ndụ na-akpali akpali ígwè.

Price na analogues nke ọgwụ

Ego ole bụ "Cymbalta" enteric capsules? Ha price nwere ike ịdị iche iche. Ọ na-adabere emeputa na ahịa ọgwụ ígwè n'akụkụ peeji. Otú ọ dị, ọ ga-ahụ kwuru na nkezi, ọgwụ na-efu banyere 1.050 Russian rubles (30 mg, 14 iberibe). Ọ bụrụ na ị chọrọ ịzụta a na nkà mmụta ọgwụ na otu ego, ma a onunu ogwu nke 60 mg, mgbe ahụ, ị ga-akwụ banyere 1150 rubles.

Ugbu a, na ị maara otú ihe bụ duloxetine. Ya price nwere ike ma ọ bụ ọnụ dabere na ụfọdụ ihe. Ugbu a, ndị zuo a na-akpọ ọgwụ ihe ọ bụla ihe isi ike. Otú ọ dị, ị nwere ike ịzụta ya naanị site ọgwụ.

Ma ihe ma ọ bụrụ na ị na n'ihi ihe ụfọdụ na-adịghị ike ịzụta a "Cymbalta" ọgwụ capsules? Analogs nke a ọgwụ ndị dị na ọ fọrọ nke nta ọ bụla na-ere ọgwụ. Ọ bụ ezie na nnweta ga-achọ ọnụnọ nke a ọgwụ si a dọkịta.

The ọgwụ nwere ike dochie anya "Cymbalta?" N'etiti ọgbọ ya ga-achọ karịsịa mata ndị na-esonụ ọgwụ:

• "Intro";
• "Azafen" (mbadamba);
• "Duloxetine Canon" (Enteric capsules);
• "Venlafaxine Sandoz";
• "Alvent";
• "Mirtazapine Canon";
• "Eprobemide" (ngwọta na / na / m);
• "Wellbutrin";
• "Eprobemide" mbadamba;
• "Agomelatine";
• "Neyroplant";
• "Velafaks";
• "Calixtus";
• "Venlaksor";
• "Vensuert";
• "Dapfiks";
• "Venlift od";
• "Despres ';
• "Efevelon ghara";
• "Doppelgerts Nervotonik" dị ka ihe Elixir;
• "Inkazana";
• "Efevelon";
• "Coaxil";
• "Esprital";
• "Lerivon";
• "Trittiko";
• "Normazidol";
• "Mirzaten";
• "Tetrindol";
• "Mirtazonal";
• "Remeron";
• "Mirtalan";
• "Pirazidol";
• "Negrustin";
• "Nyuvelong";
• "Noksibel".

The usoro nchekwa na adị ndụ

Gịnị bụ adị ndụ nke ọgwụ "Cymbalta?" Dị ka ntụziaka, na ụbọchị na mkpo, ngwá ọrụ a na-ekwesịghị iwere ka a oge nke afọ atọ. Na nke a, ọ ga-echekwara na ọchịchịrị ebe okpomọkụ adịghị gafere 20 degrees.