Elu creatinine. Ihe ihe a pụtara na otú e si eme ka arụmọrụ azụ nkịtị

Creatinine - ọgwụgwụ ngwaahịa nke nitrogen metabolism. Nke a na egosi enye gị ohere soro ndị ọrụ nke akụrụ na uru nke ahụ anyị. Dị ka larịị nke ngwaahịa (n'ihi na nke a dị gị mkpa a ọbara ule maka creatinine) nwere ike hụrụ na excretory gbasara akụrụ ọrụ na ọnọdụ nke muscle anụ ahụ. Ọ na-kpụrụ na uru, mgbe ahụ wepụtara kpọmkwem n'ime ọbara na-anyụpụ si akụrụ nke ahụ ahụ na mmamịrị.

The mfe usoro nke nchọpụta nke ọtụtụ ọrịa bụ ọbara ule. Creatinine na nwanyi (larịị) ubé ala etoju na ndị ikom na (ya ego dịgasị n'etiti 45.5-81.3 mmol / l, ndị ikom - 61.3-105.2 mmol / L). Ya mere, arụmọrụ ga-adị iche dabere na okike. Mụbara creatinine na ndị ikom na n'ihi na muscle uka ha nwere ọzọ (na ọ bụ n'ozuzu na ụmụ - 26,0-61,5 mmol / l).

Ihe Kpatara (isi) ụba creatinine:

• Nọmalị, elu creatinine, ọtụtụ na-eme egwuregwu (a nnukwu ego nke muscle uka), ndị ahụ na-eri nnukwu ichekwa anụ-eri, na-ewere ọgwụ ( "Ibuprofen", "Tetracycline", "Cefazolin").
• Nnukwu gbasara akụrụ odida. E nwere ọtụtụ ihe maka nnukwu gbasara akụrụ odida. The kasị: ujo na-ekwu, ọtụtụ ọbara ọgbụgba, nephrotoxic bekee nsi, nnukwu gbasara akụrụ ọrịa, ero nsi, bilateral gbasara akụrụ mmerụ. Isi mgbaàmà nke nnukwu gbasara akụrụ odida na-anuria (enweghị urination), ọgbụgbọ, vomiting, ọnwụ nke agụụ, lethargy, ndị nwere ihu ọma otu mgbaàmà nke ọrịa, nke mere ka nnukwu gbasara akụrụ odida.

• Mụbara creatinine dị ka a nnukwu uka n'ime mbibi nke muscle emep uta eri (e.g., etipịa syndrome). N'oge mmebi anyị uru tọhapụrụ a nnukwu ego nke creatine na esịmde systemic mgbasa, na-na akụrụ na-adịghị jikwaa ya ngwa ngwa anyụpụ si ahụ anyị.
• Na hyperthyroidism na elu creatinine. The pathogenesis na-ụba mmebi nke muscle esiwọrọ n'okpuru nduzi nke ngafe thyroid hormone, na ụba autolysis nke muscle-eduga onye na-abawanye na ọbara creatinine.

Na-akọwapụta elu creatinine na ọbara, bụ isi ewepu iche iche akụrụ ọrịa. Iji mee nke a, mụụrụ a usoro nke ule na ọtọ ule. Otu ihe dị mkpa mmebi, nke na-enye ohere ikpebi ọrụ nke akụrụ bụ creatinine nwechapụ nke endogenous (Rehberg nyocha). Ọ bụ nke a nyocha bụ a rụọ ọrụ nke ọma usoro nke na-ekpebi gbasara akụrụ ọrụ tụnyere ndị dị mfe na-amata ọtụtụ ọbara creatinine.

The ọbara creatinine etoju amalite ebili na-emetụta ihe karịrị 50% nke nephrons, na nwechapụ gbanwere ogologo oge tupu ndị na-abawanye nke ọbara creatinine.

N'ihi ya, ekele a sample nwere ike ịchọpụta na ọrịa a na preclinical nkebi ma nweta oge bara uru maka ihe ịga nke ọma ọgwụgwọ.

Ibelata ọbara creatinine nwere ike na-ewepụ ihe na-akpata ya na-abawanye, dị ka nke a na ụba ọnụego bụ naanị a mgbaàmà nke ọrịa. A gụnyere ya nwere ike nweta protein-free nri.