Medicine "Cyclophosphan": ntụziaka maka iji, ọnụahịa, analogues, emeputa na nyocha

"Cyclophosphamide" bụ alkylating compound. A ọgwụ antitumor n'ụlọnga. Ọ na-emepụta dị ka a na-acha ọcha ma ọ bụ fọrọ nke nta dị crystalline ntụ ntụ. Ọzọkwa nkọwa banyere nke a ọgwụ.

"Cyclophosphamide" - emeputa

Mee ka ọgwụ na Russian ụlọ ọrụ JSC "n'ihi mmiri ọgwụ." Ọ na-emi odude ke obio Saransk n'okporo ámá Vasenko, d. 15a.

eri nke

ị pụrụ ịzụta na ntụ ntụ №1 «Cyclophosphamide" na ihe ọ bụla na-ere ọgwụ. Ya price bụ na gburugburu 90-98 rubles.

The ọgwụ forms

Site na nke a ntụ ntụ, ngwọta dị njikere. Ọ na-zubere maka intramuscular na igba ogwu n'akwara ochichi

atụmatụ mejupụtara

The mejupụtara nke ọ bụla mkpọ na ntụ ntụ na-agụnye nọ n'ọrụ ụdị umi-akpọ "cyclophosphamide". Ụfọdụ bụ nọmba ya. Ya bụ na e dere "Cyclophosphamide" 200 mg nke kwuru umi kwa mkpọ. Nke a na ọgwụ ngwaahịa dịghị excipients.

Description nke pharmacological edinam

Dabere na ntuziaka maka ojiji, "Cyclophosphamide" - bụ ihe alkylating cytostatic ọgwụ. Ya chemical mejupụtara yiri bekee ndị dị otú ahụ dị ka nitrogen mustard. Pharmacological mmetụta "cyclophosphamide" bụ mejuputa transverse ụdị crosslinking n'etiti DNA na RNA uzo. Ọzọkwa a nkwadebe na-akwalite protein njikọ mgbochi.

"Cyclophosphamide" - analogues

Na nke a, bulie ego nke dakọtara na koodu Kiriat-anọ na udi. Oputara peculiar bụ "Cyclophosphamide". Analogs nke a ọgwụ e nwere ọnụ ọgụgụ buru. The kasị bụ:

1. "Endoxane".
2. "Ifosfamide".
3. "Alkeran."
4. "Holoxan"
5. "Ribomustin".
6. "Leykeran".

The nhọrọ nke ọ bụla nke preparations mere site dọkịta na n'otu n'otu. Na nke a, ọ na-ewe n'ime akaụntụ ahụ ike na ndidi mmiri.

Mgbe ụfọdụ, a?

Ka anyị tụlee a na ihe zuru ezu. Oputara peculiar bụ ojiji nke ndị dị otú ahụ a ọgwụ dị ka "Cyclophosphamide". Ntuziaka maka ojiji nke a bụ ihe dị oké ngwá ọrụ. Ọ na-ekwu na ọgwụ na-egosi na ndị na-esonụ mgbe:

1. Ọ bụrụ na ị na-enwe-adịghị ala ala na nnukwu lymphocytic leukemia.
2. Na ọnụnọ nke multiple myeloma.
3. Ọ bụrụ na mgbaàmà nke na-abụghị Hodgkin lymphoma.
4. Na omume nke mycosis fungoides na retinoblastoma.
5. Na ọnụnọ nke Hodgkin ọrịa na ovarian na ara ọrịa cancer.
6. Mgbe mpụta ìhè nke mgbaàmà nke neuroblastoma.

E wezụga ihe a nile, na ọgwụ na-eji na Nchikota na ndị ọzọ ọgwụ ọjọọ antitumor mmadụ maka ọgwụgwọ nke ndị na-esonụ ọnọdụ:

1. Mgbe izizi cell etuto ahụ.
2. Eriri afo cancer na akpa ume.
3. Sarcoma nke rọrọ anụ ahụ ụdị.
4. Na omume nke prostate na cervical cancer.
5. Mgbe Ewing si sarcoma.
6. N'ihe banyere Wilms 'etuto ahụ.
7. Mgbe retikulosarkome.

Ọzọkwa dị nkwadebe dị ka "Cyclophosphamide", Ibọrọ nke ọma, bụ irè dị ka ihe immunosuppressive gị n'ụlọnga ụdị na-aga n'ihu na ngosipụta nke autoimmune ọrịa. Na nke a ọ pụtara na onye ahụ nke psoriatic na ọrịa ogbu ogbu na nkwonkwo, autoimmune hemolytic anaemia, collagen, nephrotic syndrome. Ọzọkwa kwuru n'aka suppresses aka jụrụ mmeghachi omume.

contraindications

"Cyclophosphamide" nwere ụfọdụ contraindications. Ọ nwere ike ọ gaghị eji:

1. N'oge ara oge na ime.
2. Nnọọ imebi ụmị ọkpụkpụ ọrụ.
3. Ọ bụrụ na mgbaàmà nke hypersensitivity.
4. Mgbe oge urination.
5. Na ọnụnọ nke nọ n'ọrụ na-efe efe.
6. N'oge ngosipụta nke cystitis.

The ịkpachara anya dị mkpa "Cyclophosphamide", analogues nke nke na-depụtara n'elu, ndinọ ụfọdụ ikpe. Ya bụ, na ọnụnọ nke ndị na-esonụ ọrịa:

1. Nefrourolitiaza.
2. Oké ọrịa obi, ọrịa imeju na-na akụrụ.
3. Gout.
4. Akpụ infiltration nke ụmị ọkpụkpụ mkpụrụ ndụ.
5. Adrenalectomy.
6. Suppression nke ụmị ọkpụkpụ ọrụ.

Description of mmetụta

"Cyclophosphamide", synonyms (analogues) nke na-kwuru n'elu, nwere ike na-eme ka ntoputa nke ndị na-esonụ mmetụta:

1. The digestive usoro nwere ike gosi na mgbaàmà ndị dị otú ahụ dị ka vomiting, ọgbụgbọ, anorexia, ahụ erughị ala, stomatitis, ihe mgbu na abdominal ebe, afọ ọsịsa ma ọ bụ afọ ntachi. Ọzọkwa mara na onye ikpe nke jaundice na hemorrhagic afọ.
2. Na hematopoietic usoro ngosipụta a hụrụ neutropenia, anaemia, thrombocytopenia, leukopenia. On ụbọchị 7-14 n'ikuku nwere ike ubé ibelata ihe ndị platelet na leukocytes.
3. Na akpụkpọ ngosipụta nke alopecia hụrụ. Too ntutu ọzọ mgbe zuru ezu ọgwụ. Ke adianade do, n'oge ọgwụgwọ nwere ike ime na akpụkpọ ọkụ ọkụ. E nwekwara ike ịbụ na ọnụnọ nke pigmentation nke anụ ahụ na ntu mgbanwe.
4. Na obi usoro mgbe ndinọ elu doses nke ọgwụ ruo ogologo oge nwere ike ịbụ a pụta ìhè nke cardiotoxicity. Ọ dị mkpa ka na-echeta. Ke adianade do, anyị hụrụ ntoputa nke mgbagwoju, na mgbe ụfọdụ na-egbu egbu, ikpe nke obi ọdịda. Nke a bụ n'ihi na omume nke myocarditis hemorrhagic ụdị.
5. Na urinary tract nwere ike ime ka necrosis nke gbasara akụrụ ọwa (gụnyere ọnwụ), hemorrhagic cystitis ma ọ bụ urethritis, urinary eriri afo fibrosis. Na obere okwu, ndị na ngwa nke elu Dosages ọgwụ nwere ike ime nephropathy, hyperuricemia na gbasara akụrụ ọrụ. Ọnụnọ nke epithelial sel ke mmamịrị nwere ike ime.
6. Na akụkụ okuku ume usoro nwere ike ịbụ a pụta ìhè nke interstitial akpa ume fibrosis.
7. The omumu usoro ọrịa nwere ike ime oogenesis na spermatogenesis, na Vol. Ikpeazụ mgbaàmà na ụfọdụ, ọ pụrụ ịbụ irreversible. Ọtụtụ ndị inyom na na ngwa nke gị n'ụlọnga hụrụ mmepe nke amenorrhea. Mgbe ọgwụgwọ, na-enwechi anya menses emekarị gbakee. Men na-ewere ọgwụ nwere ike ime ka ntoputa nke oligospermia ma ọ bụ azoospermia, nakwa dị ka mgbanwe degrees nke testicular atrophy.
8. Na nke a pụrụ hụrụ na nfụkasị Jeremaya. Nke bụ ngosipụta nke a akpụkpọ ọkụ ọkụ, itching, aṅụ, anaphylactic Jeremaya mere.
9. Ọzọkwa na nke a, e nwere omume nke mmetụta. Ntụgharị ọbara na ọdịdị ihu akpụkpọ, nācha ọbara-ọbara, ịza aza sekọndrị etuto ahụ, oké sweating, isi ọwụwa.

iche nke na mmekọrịta

Mgbe anata a ọgwụ, ụfọdụ ọcha na-eme ka microsomal ọxịdashọn na imeju, nwere ike ime eme usoro rata microsomal metabolism nke cyclophosphamide. Nke a na-eduga ná ụfọdụ ihe. Ya bụ, a nnukwu guzobere alikiliruyuschego ụdị metabolites. Nke a na-ebelata oge maka nke ọkara ndụ nke cyclophosphamide a rụrụ, na-enwekwu ya ọrụ. Cyclophosphamide, nke na-ịrịba ruo ogologo oge na-egbochi cholinesterase ọrụ, meekwa ka ihe nke suxamethonium. ọ na-enyere aka belata ma ọ bụ jiri nwayọọ na-metabolism nke cocaine. N'ihi ya, enwekwukwa ma ọ bụ na ụba oge nke ya mmetụta na enwekwu ihe ize ndụ nke na-egbu egbu mmetụta. Nke a nwere a na-adịghị mma utịp ke ofụri organism. Ke adianade do, imekotaotuugbo ngwa nke allopurinol pụrụ iso na-egbu egbu na mmetụta na-ụmị ọkpụkpụ.

Mgbe ngalaba-ndinọ na cyclophosphamide allopurinol, colchicine, probenecid, sulfinpyrazone nwere ike mkpa mgbazi doses protivopodagricakih ụdị ọgwụ ọjọọ na ọgwụgwọ nke gout na hyperuricemia. Ọzọkwa, mgbe a na-abawanye nwere ike gosi na nephropathy ize ndụ na-ejikọta ya na ụba mmepụta nke uric acid iji cyclophosphamide.

Nke ikpeazụ umi nwere ike ime ka onye na-abawanye na anticoagulant ọrụ. Ebe ọ bụ na nke a njikọ na imeju mbelata ihe na-akwalite ọbara clotting na isi platelet mmepụta. Otú ọ dị, e nwekwara ike ime a ọnụ anticoagulant ọrụ site na-amaghị usoro ụdị.

Cyclophosphamide enhances cardiotoxicity nke daunorubicin na doxorubicin. Ọzọ immunosuppressive elekọta mmadụ (chlorambucil, azathioprine, tacrolimus, corticosteroids, mercaptopurine, wdg) nwere ike ekwe omume nke abụọ na-efe efe na etuto ahụ.

The imekotaotuugbo ojiji nke lovastatin na ọrịa na obi transplantation nwere ike dịkwuo ize ndụ nke ọrịa ndị dị ka rhabdomyolysis na nnukwu gbasara akụrụ odida.

Ọ bụrụ na Nchikota na a ọgwụ na-eji myelosuppressive ọgwụ ọjọọ ma ọ bụ ụzarị ọkụ ọrịa, ọ bụ omume na ediyarade mmako mgbochi nke ụmị ọkpụkpụ ọrụ.

N'otu oge ochichi nke cytarabine na elu doses na a ihe dị otú ahụ dị ka cyclophosphamide, na preparatory ogbo ka ụmị ọkpụkpụ transplantation usoro na-eduga ná cardiomyopathy na-amụba ugboro ole mmalite nke ọnwụ.

The isi ibiere

Na ngwa na-elebara ndị na-esonụ:

1. N'oge ọgwụgwọ na a ọgwụ ha kwesịrị ịna-ebu a ọbara ule itule ogo nke omuma myelosuppression. Ọ bụ karịsịa dị mkpa ka ntị ka ọnụ ọgụgụ nke ndị platelet na neutrophils.
2. Ị ga-ahụ mgbe nile-emezu a mmamịrị ule n'ihi na ọnụnọ nke ọbara uhie cell ọnụ. Ọnụnọ ha nwere ike na-eme ka mmepe nke ọrịa ndị dị ka hemorrhagic cystitis. N'elu nchọpụta nke ndị dị otú ahụ ihe mgbaàmà ọgwụgwọ na "Cyclophosphamide", ego nke nke na-e depụtara n'elu, ị ga-akwụsị.
3. Ka ọnụ ọgụgụ nke kpụkọta (erughị 100,000 / ml) na / ma ọ bụ mkpụrụ ndụ ọbara ọcha (<2500 / L) nke na-anata n'aka ga-akwụsị.
4. Mgbe ọrịa pụtara na oge nke usoro ọgwụ, kwuru, sị ọgwụgwọ a ga-kwụsịrị ma ọ bụ etre. Ma na ikpe nke na-anata na onunu ogwu ga-belata. Ikom na ndị inyom n'oge ọgwụgwọ usoro, "cyclophosphamide" bụ mkpa na-eji a pụrụ ịdabere na ụzọ nke igbochi afọ.
5. N'oge ọgwụ na a ọgwụ mkpa zere ịṅụ mmanya.
6. N'ihe banyere ebe elapse mbụ ụbọchị iri mgbe ọrụ, nke a rụrụ n'okpuru general ná Nkụnwụ Ahụ, na ọrịa a na-kenyere "Cyclophosphamide", ego nke nke na-e depụtara n'elu, ị kwesịrị ị na gwa nkụnwụ tinyere.
7. Ndidi mgbe ọ ẹkenịmde adrenalectomy, ọ dị mkpa na-ebu na-ejide a onunu ogwu ukpụhọde ka corticosteroids, nke na-eji dochie anya ọgwụ usoro, na ndị dị otú ahụ a ọgwụ, dị ka a ọgwụgwọ, "Cyclophosphamide".

dị mkpa anya

N'ikuku nke ọgwụ ekwe omume nanị n'okpuru nlekọta nke a dọkịta nwere ahụmahụ na-anara ọgwụ. Ọ ga-abụ na nlezianya nnabata ya na onunu ogwu ọchịchị. Nke a ga-eme karịsịa na Nchikota ọgwụ. Ọzọkwa, adịghị mkpa na-eji ọzọ ibawanye nke dose ọ bụrụ na gara aga otu e Agbaghara. Na njikere nke a ọgwụ maka ojiji na ụmụ ọhụrụ na-adịghị atụ aro iji diluents nke nwere benzyl mmanya. Ebe ọ bụ na nke a nwere ike na-eduga mmepe nke na-egbu egbu na-egbu egbu syndrome. Ya bụ, onye ahụ nke metabolic acidosis, CNS ịda mbà n'obi, akụkụ okuku ume na ọdịda, gbasara akụrụ odida, hypotension, ọdụdọ, intracranial hemorrhage.

N'oge dum ọgwụgwọ na-atụ aro na-ebu a mịnye ya ọbara (1 oge kwa izu 100-125 ml). Nke a ga-eme n'ihi nzube nke mgbochi nke ọrịa ndị dị ka hyperuricemia na nephropathy, nke bụ n'ihi na e guzobere ụba ichekwa uric acid. Ndị a mgbaàmà ukar na mmalite nke ọgwụgwọ oge. Ọzọkwa, tupu kwuru usoro ọgwụ na n'oge awa 72 mgbe ochichi na-na-atụ aro na-arụ a ụfọdụ ọmụmụ oriri (banyere 3 lita kwa ụbọchị), na ojiji nke allopurinol (pụrụ iche ikpe), na n'aka nke mere alkaline mmamịrị. N'ihi mgbochi nke ngosipụta nke hemorrhagic cystitis bụ mgbe ọ dị mkpa na-ebu nsị nke eriri afo ma na-"UROMITEKSAN". Ọ bụrụ na e nwere ndị na mbụ ihe ịrịba ama nke ọrịa, na-agwọ si nkwadebe ga-akwụsị ruo mgbe zuru ezu mkpochapu ọ bụla mgbaàmà.

Iji attenuate ụdị dyspeptic phenomena nwere ike cyclophosphamide n'ime ụbọchị mbụ na obere doses. Complete ma ọ bụ ele mmadụ anya n'ihu alopecia, nke nwere ike ime n'oge ọgwụgwọ bụ reversible na mgbe N'ezie na-ebelata ịrụ ọrụ nke nkịtị ntutu ibu. Otú ọ dị, ha na agba na Ọdịdị nwere ike ịgbanwe agbanwe.

Ọ bụrụ na ị na-enwe akpata oyi, fever, ụkwara ma ọ bụ hoarseness, ihe mgbu ke ala azụ ebe, ma ọ bụ na akuku, na-egbu mgbu ma ọ bụ ike urination, na-agba ọbara ma ọ bụ ọbara na-agba, nwa oche, ọbara na stool ma ọ bụ mmamịrị ga ozugbo ịkpọ onye dọkịta.

Ekwe omume nke thrombocytopenia, na-eduga mkpa pụrụ iche na-elekọta n'oge eme otú ahụ dị ka invasive usoro na eze na-usoro. Ọ na ha kwesịrị ịna-enyocha anụ na mucous membranes na igba ogwu n'akwara saịtị. Nke a bụ iji chọpụta ihe ịrịba ama nke ọbara ọgbụgba. Ọ dịkwa mkpa na-amachi ugboro nke venipuncture ma jụ intramuscular ogwu ogbugba. Ọ dị mkpa ịchịkwa ọbara ọdịnaya feces, igbo, mmamịrị. Ndị ọrịa na oké ịkpachara anya ga-arụrụ shaving usoro, ịkpụcha mbọ aka, dentifrices, toothpicks, wdg oghere N'otu oge ahụ ga-nditịm ẹse Falls na ndị ọzọ unan. Acetylsalicylic acid na mmanya na-aju na-amụba ihe ize ndụ nke eriri afọ ọbara ọgbụgba. Na nke a ọ dị mkpa iji mejuputa a na-egbu oge ịgba ọgwụ mgbochi ọrịa oge (mgbe 3-12 ọnwa mgbe ikpeazụ na-anara ọgwụ N'ezie ẹkụre). Ọ na-achọsi ike iji zere kọntaktị na nje ọrịa. N'oge ọgwụgwọ ọ dị mkpa itinye ezigbo ogwu jikoro.

Mgbe ịkpọtụrụ kwuru ọgwụ na mucosa ma ọ bụ akpụkpọ ga-juputara rinsed na mmiri nkịtị na òkè ma ọ bụ na ncha, karị.

Ara na ime

E nwere a peculiar mmachi na nke a, nke nwere "Cyclophosphamide". Manual na-egosi na contraindicated bụ ojiji nke a ọgwụ n'oge ime. Na nke a, na udi nke mmetụta na nwa ebu n'afọ denoted «D» site FDA. N'oge ọgwụgwọ ọ dị mkpa ka a kwụsị ya ara.

ovadozu

Na nke a, e nwere ndị ụfọdụ nuances. Ọnụnọ nke a kpọmkwem ngwọta na-ovadozu nke kwuru Nwa amaghị. Ọ bụ a pụrụ ịdabere na eziokwu. Na ovadozu ngwa ga mejuputa akwado jikoro gụnyere ọgwụgwọ kwesịrị ekwesị nke na-efe efe, dị ka nke ọma dị ka itie gbasara obi na / ma ọ bụ myelosuppression.

nchekwa ọnọdụ

Na nke a, ọ na-achọ ụfọdụ ọnọdụ ndị dị otú ahụ nkwadebe dị ka "Cyclophosphamide". Ntuziaka maka ojiji kwuru na ọ ga-echekwara na okpomọkụ adịghị nnọọ 10 ° C na a n'ebe dị akọrọ na-echebe site na ìhè. Na nke a ụmụ ohere ọ ga-nanị.

adị ndụ

Na e nwere ụfọdụ oge nke ndị dị otú ahụ a ọgwụ ike ga-eji dị ka "Cyclophosphamide". Ntuziaka maka ojiji na-egosi na ya na-arụ ọrụ ndụ bụ 3 afọ. Na nke a, ị kwesịrị ị na-agbaso ụfọdụ ọnọdụ. Ọ dabeere n'eziokwu na nditịm ajuru aju ojiji nke a ọgwụ mgbe oge a expires.

mmejuputa iwu

Na nke a direction, e nwekwara a ọnọdụ nke "na Cyclophosphamide". Ntuziaka na ngwa na-egosi na ọgwụ a tọhapụrụ naanị na pharmacies site ọgwụ.

ọgwụgwụ

Na nke a ederede, e nwere ọtụtụ ihe ọmụma bara uru. Na dị nnọọ ihe a "Cyclophosphamide", ntuziaka maka ojiji, ego nke a ọgwụ. Otú ọ dị, onye kwesịrị iburu n'uche na tupu n'itinye ọgwụ kwesịrị ịkpọ na a ruru eru dibịa.