Ọgwụ "El-Thyroxine": ntuziaka maka ojiji, analogs, reviews

Drug "Al-thyroxine" - sịntetik thyroid hormone, thyroxine analogue nke eke. Mgbe e na agwọ ọrịa bụ a ele mmadụ anya n'ihu akakabarede nke thyroxine ka triiodothyronine, iodo hormone na-agụnye niile metabolic Filiks na nwere bukwanu mmetụta na ọrụ nke ọtụtụ akụkụ. The ọgwụ na-eji na mgbe ebe budata belata thyroid ọrụ.

Ngwa nke agwọ ọrịa na-egosi mgbe mwepụ nke thyroid gland na ya anụ ahụ pute mgbe gland ọrụ na-adịghị chiri. Mgbe ụfọdụ ọgwụ na-kenyere ka ndị dị elu thyroid ọrụ, ma mbụ ịrụ ọgwụ na-ebelata secretion nke ayodiin-nwere homonụ. Na ndị dị otú ahụ ọrịa, mgbe ngwa nke "El-Thyroxine" ewute TTG ọgbọ usoro nke a na-njikọ nke thyroxine.

Ụdị ntọhapụ ọgwụ Efrata

"El-Thyroxine" dị na mbadamba. N'ọrụ umi bụ levothyroxine sodium. The mejupụtara nke ọgwụ nwere ike na-ewetara a dị iche iche ọnụ ọgụgụ nke isi mmiri, a kwesịrị ekwesị ọgwụ kenyere onye dọkịta. Inyeaka Efrata ọkọnọ sodium starch glycolate, calcium hydrogen phosphate dihydrate, ogologo yinye ele mmadụ anya n'ihu glycerides, dextrin na microcrystalline cellulose. Dị iche iche Nsukka Ọdịdị nke inyeaka Efrata nwere ike ịdị iche ubé.

Pharmacodynamics, pharmacokinetics, "El-Thyroxine"

The n'ọrụ mgwa nke ọgwụ na thyroxine, nke mmepụta emee ke idem, na-arụ otu ọrụ. "El-Thyroxine" na-eme ka normalisation nke metabolic Filiks, Filiks nke mmepe na uto. The edinam nke ọgwụ kpebisiri ike site ọdịnaya nke nọ n'ọrụ umi. The ojiji nke obere doses "El Thyroxine" na-eduga ná mmepe nke anabolic mmetụta, elu - kwesịrị ntọt cell na anụ ahụ oxygen ina, na mmetuta nke oxidative Filiks, ngwa ngwa metabolism na mmebi nke carbohydrates, ndi na-edozi, abụba. Ke adianade do, na elu doses ọgwụ activates Central ụjọ usoro, obi usoro.

The agwọ ọrịa amalite na-eme ihe mgbe banyere ụbọchị ise mgbe mbụ ngwa. Atọ na ọnwa isii nke na-aga n'ihu omume bụ omume na-Bibie nke asị ibe goiter ma ọ bụ belata ya size.

Absorption-ewe ebe tumadi na obere eriri afọ dị ka a N'ihi nke na-anata buru ọnụ mbadamba bụ karịa 80%, na ojiji nke nri na-ebelata. Ọfọn jikọọ na plasma-edozi, "El-Thyroxine", okwu na-egosi na njikọ ahụ bụ fọrọ nke nta 100%, nke mere ọgwụ adịghị emetụta ma hemodialysis ma ọ bụ hemoperfusion.

The kacha ịta nke isi akụrụngwa bụ ofu na ahụ mgbe awa ise mgbe ingestion nke ọgwụ. Ele Mmadụ Anya n'Ihu mwepụ nke ọgwụ na ọrịa emee ụzọ dị iche iche, dabere na larịị nke thyroid homonụ ke idem.

Na hypothyroidism ya mwepụ a rụrụ na itoolu ma ọ bụ ụbọchị iri, na euthyroid - isii ma ọ bụ asaa, thyrotoxicosis ọkara ndụ aga ngwa ngwa - na atọ ma ọ bụ anọ n'ụbọchị.

Ihe dị otu ụzọ n'ụzọ atọ nke dose ọgwụ isi mgwa edebe ke imeju, mgbe arịba ama ngwa ngwa mmekọrịta thyroxine nke bụ ugbu ke ọbara. Ọ na-adị guzobe metabolites mgbe ingestion nke mbadamba "El Thyroxine". Ntuziaka maka ojiji nke na-akọ na isi metabolism nke ọgwụ òkè a rụrụ n'ime ụbụrụ, mọzụlụ, akụrụ na imeju na. Excretion nke metabolites emepụta site akụrụ na eriri afọ.

Egosi maka ojiji nke nkwadebe "El Thyroxine"

Nnọchi ọgwụgwọ a na dabere na ojiji nke a ọgwụ kenyere ka ọrịa na hypothyroid-ekwu, nke dị iche iche etiologies, t. H. Hypothyroid (isi, nke abụọ) aa mgbe ime ihe na a ala iwe na n'ikuku n'aka nke na-ekewet nke radioiodine . "El-Thyroxine" ntụziaka na ngwa-enye gị ohere ekenye ndị na-esonụ mgbe:

• cerebro-hypophyseal ọrịa;
• Hypothyroidism congenital na enwetara;
• euthyroid goitre;
• Hashimoto ọrịa, ili 'ọrịa (ọgwụgwọ na mgbagwoju);
• na mgbaàmà nke oké ibu ma ọ bụ hypothyroidism cretinism, Bilie otu atụmatụ;
• euthyroid hyperplasia (Nchikota ọgwụ);
• ntighari nodular goiter mgbe resection na-anọghị gland ọrịa (mbadamba-eji dị ka a prophylactic agwọ ọrịa);
• akpụ malignancy (nnọchi na suppressive ọgwụ);
• neoplasms, nke na-ji dị ukwuu differentiated, hormone, nwere a ajọ agwa.

Ọgwụ na-eji na-arụ na-achọpụta ọrịa ule. Mgbe ụfọdụ, ndị na-ewe "El Thyroxine" slimming enweghị nsogbu na thyroid gland, ma dọkịta na-adịghị mma nke eji a agwọ ọrịa, n'ihi na otú a nzube.

Contraindications na-enweta ọgwụ, "El-Thyroxine"

The agwọ ọrịa na-adịghị ndinọ ka ọrịa na uche na ya mmiri. Contraindications na-agụnye:

• myocardial infarction (nnukwu ogbo);
• na-agba ọsọ gipokortitsizm mbụ untreated ma ọ bụ thyrotoxicosis;
• mbufụt nke obi muscle nnukwu okike;
• butere n'aka galactosemia;
• syndrome, nke na-emetụtakarị na absorption na eriri afọ;
• lactase erughi.

The ọgwụ na-eji na-ekwesịghị na ọrịa na-arịa ọrịa shuga mellitus, mgbe ike eru hypothyroidism, nke bụ ogologo oge a na-emeso, na ọrịa metụtara na obi ọnya:

• sredtsa ịrịa ọrịa obi;
• ọbara mgbali;
• arrhythmia;
• myocardial infarction (akụkọ ihe mere eme);
• atherosclerosis.

Ọ bụrụ na onye ọrịa nwere ụfọdụ n'ime ndị a ọrịa, na-dose na-ebelata ma ọ bụ họrọ analogue.

ọgwụ

N'oge ọgwụgwọ, a n'aka "El-Thyroxine" doses na-ahọrọ n'otu n'otu n'ihi na onye ọ bụla ndidi dabeere n'ihe àmà. Mbadamba adịghị ata, na-aṅụ na ihe efu afo, dịkarịa ala minit 30. n'ihu na-eri. Ọrịa na ọrịa na nke obi usoro ma ruru iri ise na ise na 1 n'arọ nke ibu na-kenyere a kacha nke 0,9 mg nke ọgwụ. Ndị fọdụrụ gosiri site 1.6 .mu.g na 1.8. Mgbe mbụ ogbo nke ọgwụgwọ, na-atụ aro dose nke ọgwụ maka ọrịa na hypothyroidism ndị dị ka ndị:

• Ọrịa ndị nwere nsogbu na obi usoro, kenyere ọgwụ si 75 mcg 150, nke kwekọrọ na a kwa ụbọchị dose.
• Na obi ọnya, nakwa okenye ọrịa ndinọ ọgwụ na ego nke 25 g. Mgbe ọnwa abụọ gasịrị na dose ụba 50 mcg. Mgbe e mesịrị, a oke mgbanwe na otu nkeji, na-amụba na 25 g, ruo mgbe ọ na-ekpebisi ike kacha ego nke Nwa na bụghị nkịtị TSH.

Olee otú ime ka "El-Thyroxine" dị iche iche ikpe, ọ dị mkpa iji na-aghọta ihe dọkịta. Ọ bụrụ na ọnọdụ nke arịa na obi na-akawanye njọ, ọ dị mkpa ka o degharịa usoro maka ọgwụgwọ nke ọrịa na nke obi usoro.

Mgbe hypothyroidism congenital ọdịdị nke dose nke ọgwụ a họọrọ dị ka afọ. The kasị nta ọrịa (ruo 6 ọnwa) ndinọ 25 micrograms ọgwụ, ma ọ dịghị ihe karịrị 50, achọrọ kwa onunu ogwu bụ site 10 ruo 15 micrograms kwa kilogram. Children n'okpuru afọ nke ọ bụla karịrị 1 afọ, inye 50 mg kwa n'arọ. Ọ bụrụ na afọ nke onye ọrịa bụ na nso nke otu afọ ise, nke kacha nta dose bụ 75 mcg, ma ọ dịghị ihe karịrị 100 micrograms. Mgbe afọ isii nke afọ (ụmụ n'okpuru 12) na-ekwe na-eji 100 mcg ego adịghị nnọọ ndị dose nke 150 mcg. Ụmụaka ndị ọzọ chọrọ dose họrọ na nso nke 100 na 200 micrograms.

N'oge ọrịa, ọgwụ, "El-Thyroxine", dị ka a kọrọ na ntuziaka maka ojiji maka ụmụaka n'okpuru afọ atọ kwa ụbọchị dose pụtara nye otu ugboro. Mgbe ọgwụ ọjọọ nchịkwa nri nwere ike rụrụ na ọkara otu awa. Na ọgwụgwọ nke-eto eto ụmụ na-eji ihe ngwọta kwadebere si mbadamba.

Ọtụtụ mgbe, ndị mmadụ na-ata ahụhụ site hypothyroidism,-aṅụ ọgwụ maka ndụ. Ndị kpughere thyrotoxicosis, mgbe mmepe nke euthyroid ala "Thyroxine" dụrụ ọdụ na-eji na njikọ na antitireoidinymi pụtara maka oge kpebisiri ike site dọkịta.

The ojiji nke ọgwụ n'ihi na arọ ọnwụ

Iji tufuo ngafe ibu iji 50 micrograms kwa ụbọchị pụtara. The kwa ụbọchị dose eji nke abụọ nzọụkwụ nke a ga-rụrụ ke usenubọk. Ọnụ na-esi n'aka "El Thyroxine" na-β-blocker na a onunu ogwu họrọ dabeere na usu ugboro. Na n'ihu dose escalation kwere "Thyroxine" 150 micrograms. Dịkwuo dose nwayọọ nwayọọ, mgbe ihe-ọmume nke n'ikuku pụtara ekewa ugboro atọ. Na nke a, nke ikpeazụ usoro a ga-rụrụ ọ dịghị mgbe e mesịrị ka 18:00. Ọzọkwa, dịkwuo dose β-blocker, a dị mkpa ego nke ọgwụ a họọrọ n'otu n'otu, na-ezu ike obi ọnụego kwesịrị ịbụ na nso nke 60 ruo 70 gafere kwa nkeji.

Mgbe ụfọdụ, ị chọrọ ka ibelata dose pụtara "Al-thyroxine". Mmetụta na-egosi na ọ dị mkpa iji kagbuo ma ọ bụ belata ọgwụ dose. The N'ezie ga-adịru banyere otu ọnwa, na-adịghị-ọgwụ ogologo karịa izu asaa.

Ekwela inikiet inikiet ahapụ ojiji nke ọgwụ, ya abolition emepụta nwayọọ nwayọọ, nke nta nke nta mbenata dose ka izu abụọ etiti oge. Mgbe afọ ọsịsa bụ n'ihu ọṅụṅụ gị n'ụlọnga "Loperamide" na otu ma ọ bụ abụọ capsules kwa ụbọchị. Tinyegharịa N'ezie iji na mbenata ibu, nwere ike ịbụ atọ ma ọ bụ anọ na izu mgbe e mesịrị.

Ekwe Omume mmetụta

Ụfọdụ oghom Jeremaya nwere ike ime n'oge ọgwụgwọ na "Al-thyroxine". Mmetụta mgbe eji ọgwụ na-atụ aro doses bụ nnọọ obere. N'ihi na nke mụbara agụụ nwere ike ibu, ntutu nwere ike ịda si, ọ bụ na o kwere omume ntoputa nke nsogbu na akụrụ ya. Children na Akwụkwụ na-adọ na ihe ize ndụ nke ọdịdọ, ọrịa nwere ike ịbụ ihe siri ike ma ọ bụrụ na ị gafere na set dose "Thyroxine". Na ọgwụgwọ na elu doses bụ puru omume na mmepe nke mgbaàmà nke hyperthyroidism.

Tinyere ihe ndị ọzọ mmetụta - nchegbu, nchegbu na-anaghị ekwe, ọdịdị nke N'ịdị tremor, nsogbu ihi ụra, ihe mgbaàmà nke arrhythmia na tachycardia. Ọzọkwa, e nwere ike ịbụ na arọ ọnwụ na mmepe nke afọ ọsịsa, ọnụnọ nke vomiting. Ikekwe sweating, ọnụnọ nke mgbaàmà na-eso onye agha nke rịaworo pectoris. Ụfọdụ ọrịa adịghị anabata dermatitis. Na mmepe nke oghom Jeremaya mere nke ahụ ala dose "Thyroxine" ma ọ bụ nwa oge kagbuo ọgwụ na mgbe e mesịrị na-eji a nta dose.

The Nchikota nke ọgwụ na-aba n'anya

A, otu dose of a obere ego nke mmanya a ala ebe e wusiri ike na o nweghị mmetụta na mmetụta nke gị n'ụlọnga "Al-thyroxine". Nyocha na-egosi na ịṅụ mmanya n'oge ọgwụgwọ nwere ike naanị ndị ahụ na-enweghị nsogbu na ọbara arịa na obi. N'ọnọdụ ndị ọzọ, Nchikota ọgwụ ọjọọ na ịṅụbiga mmanya ókè na-eduga ná ekwesighi pụta. Ikekwe ọ bụghị nanị na ibelata ịdị irè nke ọgwụgwọ, ma a mebiri nke imeju, Central ụjọ usoro.

Drug analogues "El-Thyroxine"

Of bughi analogs kama "Al-thyroxine" ike ga-eji "Eutiroks", "Bagotiroks". The Ọtụtụ họrọ ọgwụ "Eutiroks" nke nwere yiri egosi, contraindications na usoro onunu ogwu. Site na "El-Thyroxine" ọ dị iche naanị site ịta nke nọ n'ọrụ umi. Ọ bụrụ na onye ọrịa adịghị mma, "El-Thyroxine" analogues họpụtara ọkachamara-ewere n'ime akaụntụ peculiarities nke organism.

Nyocha nkwadebe "El-Thyroxine"

Na review, ọ kọrọ na ọgwụ mgbe eji na ala doses akwalite abụba ọkụ n'ihi osooso nke metabolism, suppression nke agụụ na-amụba calorie mmefu. Belata ọdịdị mmetụta ma ọ bụ gbochie ha mmepe aka β-blockers. Nyocha-egosi na ọtụtụ ikpokọta ọgwụ ndị dị otú ahụ n'aka. N'agbanyeghị eziokwu na "Thyroxine" na-enyere ifelata, na-eji ya maka ibu ọnwụ na-adịghị na-atụ aro. N'ihi na ndị ahụ siri ike, ọgwụ ahụ pụrụ ịdị ize ndụ.

Na ọgwụgwọ nke ọrịa metụtara na mkpọchị thyroid ọrụ, ọgwụ n'ozuzu bụ irè, ka ọ pụtara ìhè site nyochaa. Na-akọwa na ngwaọrụ na-eduga ná nkịtị itule nke homonụ, otú ahụ ka ọrịa na-eche mma. E nwere ọjọọ reviews mgbe ụfọdụ n'ihi na ịzụlite mmetụta. Ọ bụ ezie na ọgwụ ọjọọ na nwere ikike ime ka a ọnụ ọgụgụ nke oghom Jeremaya mere, ọ na-akwado ndị thyroid, adịru ahụ na-arụ ọrụ kwesịrị.

Iji "El-Thyroxine" oge na-aga ga-ewepụ ọrịa thyroid ọrịa ma ọ bụ belata ogo mgbaàmà n'oge ndụ ha nile.