Ọgwụ "Mikosist": reviews, analogues, price. Drug "Mikosist": ntuziaka maka ojiji

Drug "Mikosist" ntụziaka ntuziaka akowa dị ka ihe antifungal n'ụlọnga. The n'ọrụ mgwa nke ọgwụ fluconazole omume - a nhọrọ inhibitor nke sterol njikọ na fungal mkpụrụ ndụ. Ọ suppresses na mmadụ cytochrome usoro P450 anaghị igosipụta androgenic ọrụ, ọ bụ irè na-akwanyere pathogens nke mycosis.

Pharmacokinetics

Mgbe onu ma ọ bụ igba ogwu n'akwara agwọ ọrịa "Mikosist" (ọrụ na-egosi na nke a) ọma n'ime mmiri ahụ na anụ ahụ. Na sputum, peritoneal ọmụmụ na articular, asu, mmiri ara ọgwụ ịta yiri na-enweta n'ime ọbara plasma. Ọdịnaya nke fluconazole na cerebrospinal ọmụmụ na ọrịa na fungal meningitis bụ iri asatọ percent nke ogige ịta na plasma nke, n'aka, bụ ihe ra nrata ka dose. Mgbe otu ugboro-kwa ngwa nke-anọ-ise nke 90 percent na-enweta ịha ịta. Ọ bụrụ na ụbọchị mbụ na-a dose na ngafe nke na-emebu ugboro abụọ, ị nwere ike nwere ụbọchị nke abụọ iru 90 percent nke ịha ìgwè. Eleven iri na abụọ percent nke fluconazole jikọtara na plasma-edozi. Na elu ọbara metabolites na-adịghị achọpụtara. Pharmacokinetics adabere nnoo na akụrụ, n'ihi na ọgwụ a na-anyụpụ tumadi na-egosiputa ha, na ihe iri asatọ percent - agbanweghi agbanwe. N'ime awa atọ dialysis ịta nke nọ n'ọrụ umi ke plasma na-belata ọkara.

egosi maka

Ọ na-atụ aro iji ọgwụ ọjọọ "Mikosist" thrush, gụnyere generalized, akwadebe, Genital, mgbe ụdị ndị ọzọ nke invasive Candida ọrịa, candidemia, na n'iru ihe na-na-eme ka ntoputa nke thrush. Ọzọkwa gosiri bụ ojiji nke ọgwụ maka ndị mmadụ na mucosal candidiasis: pharynx; onu candidiasis tinyere atrophic, ịda site yi eze; na nkọlọ. Medicine "Mikosist" ntụziaka ntuziaka aro ndinọ ọrịa na-ata ahụhụ site na cryptococcal meningitis, ma ọ bụ sepsis, cryptococcosis, cryptococcal ọrịa nke anụ ma ọ bụ n'akpa ume. Ọ na-etinyere maka mgbochi nke nlọghachite nke a abnormalities na ọrịa na AIDS na ndị ọzọ ikpe nke immunodeficiency. Ọgwụ mee iji gbochie fungal-efe efe na ndị mmadụ na ịza aza etuto ahụ, susceptible ka a n'ihi nke radieshon ma ọ bụ na-anara ọgwụ imeri data. Ọzọkwa, ọgwụ "Mikosist" na-eji na ọgwụgwọ nke fungal-efe efe ukwu na toso, miri jupụtara ejupụta mycoses, gụnyere paracoccidioidomycosis, coccidioidomycosis, histoplasmosis na ọrịa na nkịtị ọgụ.

The onunu ogwu ụdị, nkwakọ, mejupụtara

Abụọ onunu ogwu iche nke agwọ ọrịa nwere "Mikosist": capsules na ngwọta maka infusion. Capsules na-mere nwere 50, 100 na 150 milligrams nke fluconazole. All nke ha na-esi ike gelatin, na ihe opaque ọcha ahu, na dị iche naanị na agba lids: y capsules nwere 50 milligrams nke nọ n'ọrụ mgwa, ìhè-acha anụnụ anụnụ okpu 100 milligrams - turquoise, 150 milligrams - acha anụnụ anụnụ. Content bụ a powdered siri ike uka ma ọ bụ na-acha ọcha (fọrọ nke nta na-acha ọcha) ntụ ntụ. Ngwa Efrata eme magnesium stearate, lactose anhydrous, colloidal sịlịkọn dioxide, talc, titanium dioxide, ọka starch, gelatin, indigo carmine. Capsules nwere 50 na 100 mg nke fluconazole, na-ahịa ke nchịkọta na otu, abụọ, anọ blisters, asaa iberibe ọ bụla. Ma ndị na-ebu 150 milligrams nke nọ n'ọrụ mgwa - na otu ma ọ bụ abụọ iberibe.

Infusion ngwọta nwere n'ụdị uzo, colorless ma ọ bụ ejighị ya kpọrọ agba mmiri mmiri. Otu nwere abụọ milligrams kwa milliliter nke nọ n'ọrụ umi. The abụọ mmiri bụ mmiri ọgwụ na sodium chloride. Akụzi ihe ngwọta na iko vials narị milliliters enịm ke katọn. Otu mkpọ nwere otu mkpọ.

Olee otú ga-ewere "Mikosist"? onunu ogwu

Ndị na-adị dose of fluconazole na cryptococcal ọrịa bụ ụbọchị mbụ nke ọgwụgwọ, 400 mg, na ndị na-esonụ ụbọchị - 200-400 milligrams. Na oge nke ọgwụ na-adabere na enen mycological amụ adakarị nrụpụta, ọ bụ mgbe ihe karịrị isii - asatọ izu. Na cryptococcal meningitis iji a na nkà mmụta ọgwụ "Mikosist" ntuziaka maka ojiji na-atụ aro iri - iri na abụọ n'izu mgbe pụta bụ na-adịghị mma na-amụ samples of cerebrospinal ọmụmụ. AIDS ọrịa mgbe ẹkụre ọgwụgwọ mbụ gosiri maka mgbochi nke nlọghachite nke cryptococcal meningitis maka a ogologo oge nke n'ikuku pụtara "Mikosist" na a dose nke na-erughị abụọ na narị abụọ milligrams kwa ụbọchị.

Na ọrịa na-akwadebe candidiasis, candidemia na ndị ọzọ na invasive Candida na-efe efe, na-emekarị ke akpa ụbọchị nke na-ewere anọ milligrams nke ọgwụ, na-esote ụbọchị ole na ole - abụọ na narị abụọ milligrams kwa ụbọchị. Bụrụ na nke oké systemic yist dose nwere ike mụbara narị asatọ milligrams kwa ụbọchị. Ọgwụgwọ a ga-aka iso maka dịkarịa ala izu abụọ mgbe mkpochapu mgbaàmà na-na-na-adịghị mma ọbara omenala. Ọ bụrụ na oropharyngeal candidiasis, gụnyere na ọrịa na mkpọchị ọgụ, ọgwụ onunu ogwu kwa ụbọchị bụ iri ise - otu narị milligrams, na-ewere ya ka ọ bụrụ oge nke asaa - iri na anọ ụbọchị. Na atrophic candidosis n'ihi yi eze na-emekarị kenyere kwa ụbọchị oriri iri ise milligrams nke ọgwụ na Nchikota na antiseptik. Ọgwụgwọ ruo izu abụọ. N'ihi na ndị ọzọ Candida na-efe efe (candiduria, esophagitis, anụ na mucosal candidiasis) kwa ụbọchị dose nke ọgwụ bụ iri ise - otu narị milligrams, ọgwụ bụ iri na anọ na - ụbọchị iri atọ.

Iji kpochapụ mmamiri candidiasis agwọ ọrịa "Mikosist" ntụziaka ntuziaka ngosipụta ịmụta singly ke ichekwa 150 milligrams. O nwere ike ịbụ maka na anọ - ọnwa iri na abua ugboro n'ọnwa ka na-aṅụ otu Capsule (150 mg) iji belata ugboro nke nlọghachi. Ọtụtụ mgbe kenyere candidiasis na mgbakwunye na nke ọgwụ ọjọọ, "Mikosist" kandụl, n'ihi na ihe atụ, "Terzhinan", "Clione-D", "Ginezol". Dabere na ogo nke ize ndụ nke fungal ọrịa, n'ihi na mgbochi nke candidiasis kwa ụbọchị atụ aro dose nke ọgwụ nwere ike ịdị iche iche site na iri ise na anọ na narị milligrams.

Na ikpe nke oké jupụtara ejupụta mycoses nwere ike mkpa iji ọgwụ na a onunu ogwu nke abụọ na narị abụọ - na narị anọ milligrams kwa ụbọchị ruo afọ abụọ. Na oge nke ọgwụgwọ na-adabere na onye na-adakarị picture: na coccidioidomycosis, ọ nwere ike mbio iri na otu na iri abụọ na anọ ọnwa, paracoccidioidomycosis - abụọ na asaa ọnwa, histoplasmosis - si atọ na iri na asa na ọnwa.

ngwa iwu

Igba ogwu n'akwara ntapu nkwadebe ga-amịnye a ọnụego nke bụghị ihe karịrị iri abụọ milliliters kwa nkeji. Ọ dịghị mkpa ịgbanwe kwa ụbọchị dose mgbe ebufe ọrịa si igba ogwu n'akwara ka ịṅụ ọgwụ. A ngwọta maka infusion bụ dakọtara na dvadtsatiprotsentnym glucose ihe; ngwọta Hartman na Ringer; ngwọta nke sodium hydrogen carbonate, potassium chloride na a glucose, sodium chloride (0.9%). Infusion nwere ike rụrụ iji nkịtị fluconazole ngwa iwu maka mmịnye, iji otu n'ime ndị na-esonụ ngwọta.

mmetụta

Ọtụtụ n'ime ndị ọrịa bụ onye na-ọgwụ ọjọọ, "Mikosist 'reviews banyere ya doo a mma. Drug n'ezie n'ụzọ dị irè eliminates fungal-efe efe ma nwere ike ime ka oghom mmetụta. Ya mere, si digestive usoro bụ ihe ize ndụ nke ọgbụgbọ, flatulence, ndiiche imeju ọrụ, nsogbu na uche nke uto, afọ ọsịsa. Ọzọkwa, ụfọdụ ndị na-ezo aka omume nke isi ọwụwa, ọdụdọ, dizziness. Ha na-ekwu na ndị dị otú phenomena ịmaliteworị obere oge mgbe na-ewere ọgwụ ọjọọ, "Mikosist". Nyocha nke ndị ọrịa ndị ọzọ nwere ihe ọmụma banyere mmepe nke ọgwụ ọgwụ anataghi n'ụdị erythema, ọkụ ọkụ, angioedema, urticaria. Tinyere ihe ndị ọzọ pụrụ ịkpata ga-kwuru alopecia, ventricular fibrillation, mkpọchị akụrụ ọrụ, hypertriglyceridemia, hypercholesterolemia, na hypokalemia.

contraindications

N'ụdị capsules ekwesịghị kenyere ọgwụ iji ụmụaka n'okpuru ọnwa isii nke afọ (mụrụ ọhụrụ ekwe na-eji ọgwụ na ụdị ihe ngwọta maka infusion). Unu na-eji nke a ọgwụ ọjọọ, "Mikosist" lactating nwanyi (nwanyi di ime mkpa ekenye ya na-elekọta), nakwa dị ka ndị mmadụ na-elu uche na Efrata esịne ke mejupụtara. Na ụba mkpa iji ịkpachara anya ka ọrịa na gbasara akụrụ / hepatic insufficiency, ekweghị ibe nọrọ nke acetylsalicylic acid.

ovadozu

"Mikosist" akwukwo ikpe nke ọgwụ ovadozu. Nyocha nke ndị mmadụ bụ onye na-ọgwụ ọjọọ na oké doses, na-egosi na mmepe nke afọ ọsịsa, ọgbụgbọ, vomiting. Na oké ikpe, e nwere ọdịdị nke ọdụdọ, paranoid omume, ịmụ anya arọ nrọ. A onye na mgbaàmà nke ovadozu ga-weere ụlọ ọgwụ, ebe gastric lavage ga-eme ka ya, dialysis, amanye diuresis, symptomatic ọgwụ.

"Mikosist" ma ọ bụ "Fluconazole": nke dị mma?

Ya mere ajụjụ ugboro ugboro jụrụ site ọrịa. N'ezie, ma ọgwụ ọjọọ bụ otu, anyị nwere ike ikwu na ha bụ ndị yiri. The naanị ihe dị iche bụ na ọgwụ "Mikosist" na-eme ka Hungarian ọgwụ na ụlọ ọrụ "Gedeon Richter", mgbe "Fluconazole" - nkwadebe nke ụlọ mmepụta. N'ezie, nke a nwere a kpọmkwem mmetụta na-eri nke ọgwụ. Ịhọrọ ihe ịzụta - "Mikosist" ma ọ bụ "Fluconazole" - ọtụtụ-ahọrọ na-ọgwụ, nke dị ọnụ ala karịa. N'ezie, a ịrịba dị iche na price. Ya mere, n'ihi na mkpo nke "Mikosista" (otu Capsule nwere 150 milligrams nke fluconazole) ị ga-akwụ nkezi nke 295 rubles, mgbe otu ngwugwu "Fluconazole" na-eri naanị 8-20 rubles. The nkezi price nke a 100 ml karama ngwọta maka infusion "Mikosist" bụ 311 rubles.

Ma ndị na-pharmacological Njirimara nke abụọ ọgwụ ọjọọ, ha na-fọrọ nke nta ka yiri, ihe dị iche nwere ike hụrụ ma e wezụga na ọnụego nke absorption: dị ka dị data, karịa ịta ke idem "Fluconazole" bụ imezu mgbe 1-2 awa mgbe ngwa, na "Mikosista" - 0,5 -1,5 awa. Otú ọ dị, ọ bụghị ihe niile ndị ọrịa ime abụọ ọgwụ dokwara. Ụfọdụ na-adịghị ahụ ihe ọ bụla dị iche n'etiti ha, mgbe ikpeazụ kwere na àgwà na-adabere na price, nke pụtara na a ọgwụ bụ ihe dị oké ọnụ, mma. I nwere ike na-chọta reviews na nke ụmụ nwanyị na-ekwu na mgbe na-ewere "Fluconazole" thrush bịara azụ, ma "Mikosist" kwere ka tufuo ya na-adịgide adịgide. Na nke ọ bụla, nhọrọ bụ gị.

analogs

Ke adianade "Fluconazole", e nwere ọgwụ ndị ọzọ na ike dochie ọgwụ "Mikosist". Analogs agwọ ọrịa na-enwe dị ka ọrụ mgwa otu umi, na-ọma na-anọchi anya. N'ụdị capsules maka ọgwụgwọ nke yist na ndị ọzọ na fungal-efe efe, i nwere ike iji "Diflucan" ọgwụ "Flucostat", "mikomaks" na ndị ọzọ. Dị irè n'aka bụ "Mikoflyukan" (mbadamba). "Mikosist" site niile ndị a dị iche iche analogs site egosi ndị dị otú ahụ dị ka bioavailability, ọkara ndụ, ọnụego nke absorption.

ọgwụ interactions

Ọ dị mkpa ka nlezianya nyochaa prothrombin oge na ọrịa na-anata fluconazole tinyere anọ anticoagulants coumarin otu, n'ihi na e nwere ihe ize ndụ nke na-amụba VWP. Mgbe concomitantly na sulfonylureas ọgwụ "Mikosist" nwere ike ogologo ọkara ndụ nke ha, otú i kwesịrị ekwe omume nke hypoglycemia. N'ihe banyere fluconazole na phenytoin nkekọrịta ike clinically ịrịba ogo abawanye nke ikpeazụ ịta, ya mere, ọ bụrụ na ọ dị mkpa jikọtara anata dose ga-belata. Ọnụ na mbanye pụtara "Mikosist" na rifampicin ga-akara ọnụ ke ịta nke fluconazole mere dose "Mikosista" chọrọ ntọt. The jikọtara ojiji nke ihe azole emepụta na a agwọ ọrịa na Nchikota na terenadinom contraindicated, dị ka nwere ike ịzụlite oké ike,-eyi ndụ egwu arrhythmia. Ọ bụrụ na ị na-na nkà mmụta ọgwụ "Mikosist" ọnụ na cisapride, pụrụ igosipụta ekwesighi Jeremaya mere na akụkụ nke obi, gụnyere ventricular tachycardia. Na n'otu oge ojiji nke fluconazole na theophylline belatara nkezi nwechapụ ọnụego si plasma nke ikpeazụ ọbara, ya mere enwekwu ohere nke mmepe nke ya na-egbu egbu mmetụta na ovadozu.

adọ aka ná ntị

Ga-anọgide na ọgwụgwọ na "Mikosist" ruo adakarị na hematological kwụsịtụkwara. Akaghi discontinuation nke ọgwụ bụ fraught na nlọghachi. Dị ka ekwuola, ọrịa na gbasara akụrụ insufficiency kwesịrị iji ọgwụ na kacha ịkpachara anya, n'ihi na ọ na-anyụpụ tumadi site na akụrụ. Ọnụọgụ ọgwụ n'oge ogologo oge ọgwụgwọ a ga-mere, na-ewere n'ime akaụntụ CC. Mgbe ụfọdụ fluconazole agụnye na-egbu egbu na mmetụta na-imeju, n'ihi ya, ọ dị mkpa iji nyochaa ịrụ ọrụ nke ahụ a. N'elu nchọpụta nke ọnya mgbaàmà kwesịrị ịkwụsị ịṅụ ọgwụ.

Ọrịa na ndabere nke "Mikosist" pụtara kemgbe obere sightings exfoliative cutaneous Jeremaya mere, dị ka na-egbu egbu epidermal necrolysis na Stevens-Johnson syndrome. Ọrịa na ịza aza neoplasms na AIDS bụ ndị na-enwekarị ntoputa nke oké akpụkpọ Jeremaya mere mgbe eji preparations nwere fluconazole. Ọ bụrụ na n'oge ọgwụgwọ nke elu ọnụ fungal ọrịa ndị ọkụ ọkụ na-egosi, ọgwụ ị chọrọ kagbuo. Ọ bụrụ na ị na-enwe ihe ọkụ ọkụ na ndị na-invasive ma ọ bụ systemic fungal ọrịa na dọkịta ga-ike na-elekọta na iwepu ọgwụ na ihe omume nke ga-etolite erythema multiforme, ma ọ bụ bullous ọnya. N'oge ọgwụgwọ, ọgwụ "Mikosist" (reviews gosi ya) nwere ike ime ka dizziness, otú ọrịa mkpa ịkpachara anya karịsịa mgbe na-arụ ọrụ na Usoro na management nke ugbo ala.