"Theophylline": ntuziaka maka ojiji. "Theophylline": egosi maka ojiji nke analogues

Ọ bụrụ na mmadụ na-ata ahụhụ site na airway mgbochi, nke a nwere ike na-egosi na ọnụnọ nke na-adịghị ala okpo ọrịa akpa ume (COPD). Ọrịa a bụ nnọọ nkịtị. Ọtụtụ mgbe, ndị omume nke ọrịa a hụrụ na-ese siga. Mmepe nke ọrịa a na-kpatara ọrịa hit, ma ọ bụ ihe ụfọdụ akpa ume mebiri. A onye na airway constriction nwere ike na o siri ike-elo. N'ihi ya, isi ihe mgbaàmà bụ ngosipụta nke ọrịa dyspnea, ụkwara, na sputum mmepụta. Ọ dị mkpa ịmara. Ọtụtụ nkịtị bụ mmepe nke ụdị ụfọdụ nke COPD. Nke a omume nke ụkwara ume ọkụ, ala ala bronchitis, emphysema, bronchiectasis. Na ọgwụgwọ nke a na ọtụtụ ọrịa ndị ọzọ ga-enyere ndị dị otú ahụ a ọgwụ dị ka "Theophylline". Ntuziaka maka ojiji nke ọgwụ ga-kpuchie na a ederede. Ọzọkwa nkọwa banyere nke a.

nkọwa

"Theophylline", onye mejupụtara ga-kọwara n'okpuru ebe a, bụ a na-acha ọcha crystalline ntụ ntụ. Ọ bụ ubé soluble mmiri oyi (na ruru 1: 180), ma na-adị mfe etisasịwo na mmiri ọkụ (na a ruru nke 1:85). Ọ na-dissolves na alkalis na asịd.

Ọdịdị

Na nke a Nwa isi n'ọrụ mgwa ihe bụ theophylline. ebe a na-agụnye ụfọdụ inyeaka mmiri. Ya bụ - lactose monohydrate, magnesium stearate, talc, methacrylic acid.

ntọhapụ Ụdị

E nwere ọtụtụ ụdị nke a. "Theophylline" arụpụtara dị ka ẹkama-ntọhapụ mbadamba (0,1 g, 0,25 g), capsules (0.125 g, 0,5 g), na suppositories (0,2 g).

pharmacological omume

Arụmọrụ nke kwuru Nwa bụ multi-faceted. "Theophylline", reviews nke ọma, ntụrụndụ na-egosipụta uru nke bronchi, nwere a na-akpali akpali na vasodilator edinam. Nke a nkwadebe ana achi achi nkịtị ọrụ nke akụkụ okuku ume na center. Kwụsị ihe mgbu na diaphragm ma melite ịrụ ọrụ nke intercostal uru-emekwa ka "Theophylline". Ya iji na usoro ebelata puru nke ngosipụta nke nfụkasị Jeremaya na akụkụ okuku ume na usoro ụdị ozu. Sị na nkwadebe pụrụ ịkpa a mamịrị mmetụta. Ọnụnọ nke-arụ ọrụ bekee na agwọ ọrịa na-akwalite normalisation nke akụkụ okuku ume na ọrụ, na-ebelata larịị nke carbon dioxide na ụba ventilashion. "Theophylline" n'ụzọ dị irè na-enwekwu akwara mgbasa. ọ na-enyere aka belata ụda olu nke arịa nke ụbụrụ, akụrụ na obi. Mgbe arụ ruo ogologo oge ọgwụgwọ a na ịgbasa biliary tract, normalisation microcirculation na erythrocyte iguzogide deformation abawanye. Na ọrịa na-ata ahụhụ site na hypotension, nwere ike ẹsụhọde ọbara mgbali. Mmejuputa iwu-nke na-anata ndị dị otú ahụ a nkwadebe dị ka "theophylline", tinyere beta-blockers, na ọgwụ nje na-eduga ná ihe ize ndụ nke mmetụta.

egosi

Kenye kwuru ọgwụ na omume nke bronchial ụkwara ume ọkụ, asthmatic ọnọdụ, okpo bronchitis, akpa ume emphysema. Ọzọkwa ọ na-eji dị ka onye aka na ụmụ a mụrụ ọhụrụ na apnea. Jiri "Theophylline" n'ụzọ bụ isi dị a bronchodilator. Ọzọkwa, ha na-eji ya dị ka a na-agafeghị oke cardiotonic (enwekwu ike nke obi contractions) na mamịrị (mamịrị) ọgwụ maka congestive ngosipụta nke gbasara akụrụ na gbasara obi si malite. Mgbe ụfọdụ, ọ na-ndinọ ọnụ na ndị ọzọ mkpali na bronchodilators.

Zuru ezu nkọwa nke ụdịdị dị iche iche nke si Nwa

Ná mmalite, na ọgwụgwọ nke COPD bụ ọrụ bronchodilators. Ha na-ebu ngosi karị. Otu n'ime ndị a ọgwụ ọjọọ, dị ka na-ama kwuru n'elu, dị nkwadebe bụ dị ka "theophylline". Ntuziaka maka ojiji e ji mara ya dị ka a bronchodilator ọgwụ, nke na-eburu ndị na-na-akpọ igbochi nke purine anabata. Ọnụnọ nke mmetụta dị otú ahụ usoro ana achi achi mwepụ nke apịajighị apịaji na-eji ire ụtọ muscle nke bronchi, mkpochapu mgbu na diaphragm, ebighị nke oxygen na akpa ume, rụọ ọrụ nke intercostal uru. Dị ka a N'ihi ya, karị emeghe, onye na-ekuru mfe.

Ọ nwere a kapịrị uru, "Theophylline". Ntuziaka maka ojiji na-egosi na a ọgwụ ike ghaghị mmetụta ọ bụghị nanị na akụkụ okuku ume na tract, kamakwa ndị ọzọ ahụ na usoro. A ọgwụ na-enyere iji mụbaa akwara na elu ọbara arịa, egbochikwa usoro nke platelet adhesion, bụ a nwayọọ mamịrị ihe. Ọ na-enye mmalite kwachaa ọrụ nke obi muscle (myocardium), ala ọbara mgbali, nakwa dị ka a bara uru utịp ke Central ụjọ usoro. N'ihi ya, ọgwụ na-enwe ike eme vasatail, n'out oge na-enwe antiasthmatic, bronchodilator, mamịrị, spasmolytic, vasodilatory na cardiotonic Njirimara.

"Theophylline": ntuziaka maka ojiji

Iji chọpụta onunu ogwu, e nwere ọtụtụ ibiere. "Theophylline", dị ka ntụziaka, gị mkpa iji ụmụaka dị afọ 14 na ndị okenye, 300 mg kwa ụbọchị 2-3 ugboro. Na nke a, na nkà mmụta ọgwụ ga na-aṅụ mmiri na nnukwu quantities. Ọ bụrụ na ọ dị mkpa, ndị dose nwere ike mụbara 500 mg 2 ugboro n'ụbọchị, ma ọ bụrụ na-atụ aro site dọkịta gị. Ọ bụrụ na onye ọrịa nwere a arọ ahụ erughị 60 n'arọ, na onunu ogwu kwesịrị 100 mg 2 ugboro n'ụbọchị. Na nke a, a kara aka ụtụtụ na mgbede n'ikuku nke a nkwadebe dị ka "Theophylline". Ntụziaka na-ekwu na-agwọ dị mkpa iji na-amalite na obere doses na-eji nwayọọ nwayọọ na-amụba ka ha na-adị. A ọgwụ ga-mụụrụ na mgbe etiti oge. Ha ga-2-3 ụbọchị. Akwụkwọ ntụziaka a kwuru, ma ọ bụrụ na ọgwụgwọ usoro dị mkpa iji na-eduzi mgbe nile na-achọpụta ọrịa usoro. Ya bụ - mmejuputa ọbara analysis, ọbara mgbali mmesho, X-ray, ECG, ikpebi larịị nke cholesterol na haemoglobin. The ngosipụta nke ọgwụgwọ mmetụta nke si n'aka-abịa mgbe ụbọchị abụọ. Ọ dị mkpa ịmara. Na a na nkwonkwo n'ikuku nke ọgwụ na antispasmodics e amụba arụmọrụ nke ọgwụgwọ usoro. "Theophylline" ebelata ihe nke ọgwụ ọjọọ antidiarrheal mmadụ. The na-agwọ ọrịa oge kwesịrị ịkpachara anya na-eme ka ọ bụla caffeinated ngwaahịa na antidepressants.

Na-ewere ọgwụ ọjọọ n'oge ime na ara

"Theophylline" mmetụta na nwa ebu n'afọ n'okpuru Atiya "C" site FDA. The ngwá ọrụ penetrates na placental mgbochi. Ụmụ nwaanyị dị ime nwere ike sị ọgwụ na n'ebe ndị na-atụ anya uru nne dị ukwuu karịa ndị nwere ihe ize ndụ ka nke nwa ebu n'afọ. Na oge nke m trimester na ikpeazụ izu nke afọ ime ga-ọgwụ, na-edebe ihe siri ike na-egosi. Ọ dị mkpa ka na-echeta.

N'ime ọtụtụ kwuru na-egosi na theophylline nwechapụ n'oge III trimester nke afọ ime na-ebelata. Nke a nwere ike ịchọ ọzọ Ugboro mkpebi siri ike nke ịta nke umi ke ọbara na a ga-ekwe omume Mbelata nke dose.

Ara "Theophylline" dara n'ime mmiri ara ehi na nwere ike ime ka ihe mgbaàmà nke ogwe na ụmụ ọhụrụ ma ọ bụ ndị ọzọ ịrịba ama nke toxicity. Ọ dị mkpa ịmara. Ịta nke kwuru umi ke mmiri ara bụ mkpokọta Ẹkot ya ọdịnaya na ọbara ọbara nke nne. Ọzọkwa, nke a pụtara budata egbochi eriri akpa nwa contractions.

contraindications

"Theophylline" ntuziaka maka ojiji dị ka akọwara n'elu, na-contraindicated ma ọ bụrụ na e nwere:

• Idiosyncrasy.
• Hyperthyroidism.
• Nnukwu myocardial infarction.
• Subaortic stenosis. Nke a na-abụghị mkpali aghara nke ekpe ventricle nke obi muscle anụ ahụ. Ọ e ji okwu nke a nkọ ibelata nke ya oghere.
• Arrythmia.
• Akwụkwụ na-adọ ndị ọzọ convulsive ọnọdụ.
• Pregnancy.

Na-elekọta, ọ dị mkpa ịrụ n'ikuku nke ọgwụ n'oge ngosipụta nke ọnyá na ọrịa nke afo na duodenum.

kpọmkwem ibiere

Ise siga na budata emetụta nketa nke metabolism na excretion nke ndị dị otú bekee ndị dị otú ahụ dị ka theophylline. Ọ ga-echeta. Persons onye na-ese siga 1-2 Ukwu nke sịga a ụbọchị, nwere a belatara ọkara ndụ oge. Na ọrịa na hepatic, gbasara obi ma ọ bụ akụkụ okuku ume na odida kwuru na, dị ka nke ọma dị ka malitere ịrịa ọrịa na hyperthermia emee deceleration mkpochapu ifịk umi. N'ikuku nke mmanya na caffeine-ụdị ngwaahịa na-nwere a ịrịba utịp ke metabolism nke theophylline.

mmekọrịta

Ọgwụ "Theophylline" na-akwalite potentiation mmetụta nke β2-agonists. Ọ nwekwara ike welie tremor, nke e mere site a sympathomimetic ọgwụ ụdị na bụ ike inhibit usoro nke absorption nke phenytoin. Ngwa ngwa mkpochapu n'aka emee ya na mmekọrịta ya na "erythromycin" na "phenobarbital." Pụtara "Theophylline" na-enye onye na-abawanye na gbasara akụrụ excretion nke lithium. Na nke a, na ọgwụgwọ itule na-amakwa jijiji na ọrịa ndị na-na-na-kwekọrọ ekwekọ salts. Ọgwụ "cimetidine" na-eme ka ịta n'ime ọbara theophylline etoju, na-enwekwu ndị oge nke ya ndọrọ ego. Ọgwụ na yiri mmetụta ga-depụtara n'okpuru.

Ọnụnọ nke mmetụta

Mgbe anata kwuru ọgwụ ọjọọ nwere ike dị iche iche na-adịghị mma mgbaàmà. Ya bụ:

• Ị nwere ike mgbaàmà nke dizziness, ehighi ura, isi ọwụwa, na-ada mbà, nchegbu, tremor, mgbagwoju anya, Akwụkwụ na-adọ.
• Na obi usoro - arrhythmia, tachycardia, ụgha rịaworo, na mberede ọnụ ke ọbara mgbali, rịaworo pectoris.
• Si digestive usoro - ntoputa nke ọgbụgbọ, vomiting, nrekasi obi, afọ ọsịsa, flatulence, afọ, mgbu.
• Mgbe olu nke ndi n'ikuku n'aka pụrụ hụrụ ụfọdụ ngosipụta nke nfụkasị Jeremaya n'ụdị itching, ọkụ, urticaria, dermatitis, fever, sweating na akpụkpọ rashes.

ovadozu

Na nke a, e nwere ndị ụfọdụ mgbaàmà. N'okpuru ndị a ngosipụta abuana:

- n'ahụhụ;

- mgbagwoju anya;

- ụfụ;

- tachycardia;

- arrhythmia;

- hypotension;

- ọgbụgbọ;

- afọ ọsịsa;

- vomiting na admixture nke ọbara;

- hyperglycemia;

- metabolic acidosis.

Mgbe ndị a mgbaàmà na-kenyere a ụfọdụ ọgwụgwọ. Ya bụ, rụrụ site na:

• Ọrụ unyi usoro.
• Irrigation region bowel Nchikota salts na polyethylene glycol ngwọta.
• Igba ogwu n'akwara n'ikuku "MCP" ma ọ bụ "Ondansetron" na-akara mgbaàmà nke ọgbụgbọ na vomiting.
• N'ikuku "benzodiazepines", "Phenobarbital" (ma ọ bụ thiopental sodium) na elu muscle relaxants na omume nke ọdịdọ.

"Theophylline": ogbo

E nwere ọtụtụ ihe dị iche iche ọgwụ ọjọọ nke a ụdị. Na nke a, tụlee ọgwụ:

- "Teobiolong" ( "Theobilongum").

- "Spofillinretard" "(Spophillin ghara").

- "Perfillon" ( "PerphyUon").

- "Neoefrodal" ( "Neo-Efrodal").

- "Franol" ( "Franol").

nchekwa

The ntụ na mbadamba ( "theophylline") echekwara na a gbara ọchịchịrị, n'ebe kpọrọ nkụ. Ha adị ndụ bụ afọ ise. Nchekwa kandụl ga-eme na friji. N'otu oge ahụ ha na-ekwesịghị oyi kpọnwụrụ. Ha adị ndụ nke afọ anọ.

N'ihi

Mgbe agụ n'elu, otu onye nwere ike were ihe a ọgwụ ndị dị otú ahụ dị ka "theophylline", ego nke nke bụ ihe dị mma (n'ime 70-160 ete.). Ọzọkwa na a ederede gwara banyere ntuziaka maka ojiji nke ọgwụ na ya na mmekọrịta ya na ndị ọzọ na-esi.