"Ginipral": ogbo. Gịnị nwere ike dochie anya "ginipral"?

Pregnancy - a pụrụ iche ala nke nwanyi ahu, nke na-achọ a na nlezianya anya kwupụta ahụ ike ha. Ọtụtụ mgbe, na dị iche iche nkebi nke gestation apụta dị iche iche ọdịdị dysfunctional ala, otu onye nke bụ onye ubara ụda olu nke akpanwa, pụrụ ịkpasu preterm òfùfè. Iji gbochie ekwesighi pụta kenyere ọnụ ọgụgụ nke bekee iji na ntụrụndụ nke myometrium. Ọtụtụ ndị dị otú ahụ dị ka obstetricians pụtara prescribers "ginipral" (mbadamba).

Ya analogues na-eji ezi mgbe, n'ihi na dị iche iche ọgwụ ọjọọ eme ihe na-emetụta onye ntule - ọma na-enyere onye nwere ike na-enye ezi mmetụta na ndị ọzọ. Ke adianade do, a ọgwụ, n'agbanyeghị na ya elu nrụpụta na mgbochi nke preterm nnyefe nwere a zuru ezu ọnụ ọgụgụ buru ibu nke contraindications na mmetụta, na-eme ụfọdụ ndị ọrịa na-atụ egwu na unwillingness na-anabata ya. Na nke ọ bụla, na-akwụsị na ntuli aka na nke a ma ọ bụ ọgwụ na-ekpebi ihe a ga-eji dochie "ginipral" na-atụ aro nanị dibịa.

Description of nkwadebe

Nkwadebe "ginipral" na-emepụta na ụdị ọcha gburugburu biconvex mbadamba nwere onye ọ bụla 500 mg hexoprenaline sulfate, dị ka a ngwọta maka igba ogwu n'akwara ochichi na a onunu ogwu nke 5 mg kwa 1 ml mmiri mmiri (10 mg nke nọ n'ọrụ mgwa kwa 1 mkpọ). Ọzọkwa na-emepụta a uche maka ihe ngwọta maka infusion (25 ug hexoprenaline sulfate na otu ampoule).

usoro nke ihe

Nkwadebe "ginipral" edinam bụ n'ihi na Njirimara hexoprenaline sulfate, na-ezo na nhọrọ beta2-agonists, na-ezo aka bekee belata ụda ma contractile ọrụ nke uru ahụ nke akpanwa (myometrium), i.e. aka egbochi akaghi òfùfè.

Mgbe ndinọ, karịsịa igba ogwu n'akwara, nnọọ ngwa ngwa ọ na-akpata a ọnụ ke ụba ụda olu nke akpanwa, nke na-enyere iji belata ugboro ole na osisi ike nke eriri akpa nwa muscle, mgbochi nke n'amaghi ma ọ bụ iwe na nhọpụta nke oxytocin contractions. Mgbe na-eji na oge nke oru aka normalize kwa ike ma ọ bụ oge ufodu contractions. Nchupu akaghi eriri akpa nwa ọrụ na-enye ohere a nwaanyị na-agwa a ime ka ezigbo maka ntoputa nke nwa deadlines.

Na mgbakwunye na kpọmkwem mmetụta nke ọgwụ nwere mmetụta ụfọdụ na steeti gbasara obi ọrụ na ọbara nke ma nne na nwa ebu n'afọ, nke a ga-atụle n'isiokwu na-oru.

na-agba akaebe

Ebe ọ bụ na agwọ ọrịa na-akpata ntụrụndụ nke eriri akpa nwa uru, na-ebelata ugboro ole na osisi ike nke contractions, na-egbochi cervical ngosi, iji "ginipral" ruru kpomkwem ka a edinam.

The ọgwụ na-ndinọ na ngwọta na ihe omume nke ihe mberede, maka ngwa suppression nke contractions:

• na ihe omume n'oge na-amụ nwa nnukwu intrauterine nwa ebu n'afọ na asphyxia;
• tupu ntuziaka adiana nke mpụta ọnọdụ nke nwa;
• a mpịakọta udo;
• na mgbagwoju anya oru na nnyefe;
• iji zuru ike akpanwa tupu caesarean ngalaba;
• akaghi oru maka mgbochi nke contractions na atụrụ ime tupu eziga ọgwụ.

Igba ogwu n'akwara ọgwụ "ginipral" na-eji:

• n'ihe ize ndụ nke preterm oru contractions;
• iji zuru uru nke akpanwa n'oge aghụghọ nke isi agịga Ma do dị n'olu ya iji gbochie ya nnwụchu ngosi;
• ibelata contractions na ala afọ ime ma ọ bụ na ụba ugboro na he na ndabere nke ihe na-adịghị njikere cervix.

The iji "ginipral" mgbe ndị dị otú ahụ na-egosi nwere ike ịchọ n'ikuku dum N'ezie nke ọgwụ na yiri ka adịru ọtụtụ ọnwa.

Mbadamba kenyere n'ihe ize ndụ nke na-emepe emepe na-anwụchu ịmụ nwa, n'ụzọ dị ukwuu dị ka a n'ihu nke infusion ọgwụgwọ.

contraindications

The iji ọgwụ ọjọọ eme jikọtara ụfọdụ dị oké njọ mmetụta, n'ihi ya, na-eji ya nanị dị ka a dọkịta, na-ewere n'ime akaụntụ nile dị na contraindications, mgbe ụfọdụ, overriding ọgwụ "ginipral", nke analogs nwere ike ọzọ na a akpan akpan ọnọdụ.

Ejila ọgwụ ruo ọtụtụ ọrịa:

• thyrotoxicosis;
• tachyarrhythmia;
• omume ọjọọ nke mitral valvụ, na aortic stenosis;
• myocarditis;
• akwara akwara ọrịa;
• ọbara mgbali;
• oké umeji ọrịa akụrụ;
• n'akuku-mmechi glaucoma;
• eriri akpa nwa ọbara ọgbụgba dị iche iche etiology, akaghi detachment nke Plasenta;
• mmepe nke intrauterine ọrịa;
• ke akpa trimester nke dị ime;
• lactation (ara);
• hypersensitivity ọgwụ (akpan akpan bronchial ụkwara ume ọkụ ma ọ bụ uche na sulfites na akụkọ ihe mere eme).

Ọnụnọ nke a ndepụta megide agha na ụfọdụ ịchọta a nnọchi ọgwụ "ginipral", ihe analogue nke dịghị mfe bulie, dị ka ọ nwere a kpọmkwem utịp ke myometrium bụ, kama nke dum ezigbo uru n'ozuzu.

atụmatụ ngwa

Dị ka ekwuola, ngwaọrụ nke "ginipral" na-achọ ike na-egosi na nkenke nke usoro onunu ogwu. Igba ogwu n'akwara ochichi na-achọsi ike iji na-emepụta na a ọgwụ ebe eji akpaka metering ma ọ bụ igba ogwu n'akwara infusion nfuli, ebe ọ bụ na ọgwụ ọjọọ na omume na-agụnye jiri ya nnyefe n'ihi 5-10 nkeji.

Ọ bụrụ na nke mberede, iji ngwa ngwa kwụsị contractions ngwọta e ji mee ihe na a dose nke 10 micrograms (otu ampoule nwere 2 ml nke ngwaahịa), na "ginipral" sochiri infusion nke ọgwụ. Ntapu kenyere na a nnọọ ngwa ngwa iwebata na a ọnụego nke 0.3 g / min. Ọ bụrụ na ọ na-ẹkekerede gradual ọnụ nke eriri akpa nwa ọrụ, ihe ngwọta na-ndinọ ruo ogologo oge (0.075 g / min).

Ọ bụrụ na ihe nke a n'ihu ọgwụgwọ ọgwụ nwere ike rụrụ iji mbadamba nkume na a dose nke 500 ug, nke nwere ike ikwu na-aṅụ ọtụtụ mmiri, ma ọ bụghị na kọfị ma ọ bụ tii, nke nwere ike welie oghom mmetụta nke ọgwụ. The kwa ụbọchị dose bụ 4-8 mbadamba iberibe mgbe na-ewere ha otu otu site na mbụ mbadamba 3 h, mgbe - mgbe 4-6 awa.

adọ aka ná ntị

Ọnụnọ nke a ọnụ ọgụgụ buru ibu nke mmetụta na-achọ nlekota nke ahụ ike na ọnọdụ nke onye ọrịa ahụ na nwa ebu n'afọ, akpan akpan, mkpa inyocha na ịchọpụtakwa ọrụ nke obi usoro. Ọ na-achọsi ike ime ihe ECG n'ihe tupu ọgwụgwọ na n'oge ya.

Ọ bụrụ na onye ọrịa nwere ụba uche dị otú ahụ ọgwụ ọjọọ eme ihe, ọ na-ndinọ na obere doses, họọrọ nditịm onye, na mgbe nile na-nlekota nke n'imeso dibịa.

Ọ bụrụ na e a akpọ tachycardia na ala ọbara mgbali, belata dose. The ngosipụta nke ndị dị otú ahụ ihe mgbaàmà dị ka iku ume ọkụ ọkụ, ihe mgbu na obi, ihe mgbaàmà nke gbasara obi ischemia, na-agụnye ozugbo kagbuo a ọgwụ. Iji belata n'akụkụ-mmetụta na-ndinọ na mgbakwunye na nke ọgwụ ọjọọ, "ginipral" "Verapamil", nke bụ iji na iche na mmetụta ọjọọ na obi usoro.

Na-abawanye na ọbara glucose etoju mere site n'iji ngwá ọrụ a, mkpa ka i jiri nlezianya nyochaa arụmọrụ nke carbohydrate metabolism na ụmụ nwanyị na-arịa ọrịa shuga.

Nkwadebe "ginipral" na-enyere belata mmamịrị mmepụta, n'ihi ya, ọ dị mkpa iji akara mgbanwe nile na ike ga-ejikọta ya na njide nke ahụ ọmụmụ. Mgbe ụfọdụ coadministered na corticosteroids nwere ike ịkpata akpa ume edema, ya mere, mgbe nile na nlekota oru bụ mkpa na-ebu n'oge infusion oge na maka injectate olu.

mmetụta

Mgbe na-eji a ọgwụ mgbagwoju ike nke na-akpali dum, dị ka a ọgwụ ọjọọ, "ginipral" mmetụta nwere ike ime ihe ọ bụla na ahụ usoro:

• a na-ezighị ezi pụrụ isi kwuo na etiti na elu ụjọ usoro e ji isi ọwụwa, ajụ obubu, nchegbu, a nta tremor na mkpịsị aka;
• mmetụta na obi usoro nwere ike ime ka a dị ime tachycardia, hypotension (na-emekarị diastolic), ọtụtụ obere nwere ike a mebiri nke n'afọ iri na ụma (ventricular akaghi gafere) ma ọ bụ kardialgiya ngwa ngwa ruo na mgbe-ekpochapụ ọgwụ ọjọọ;
• obere ọrịa nke digestive tract nwere ike na-egosipụta site ọgbụgbọ, vomiting, mgbochi nke nsia motility ruo mgbe zuru ezu ọnọdụ na-achọghị nri amaghị onwe;
• ma ọ bụrụ na e nwere uche ọgwụ nwere ike ime ka nfụkasị Jeremaya mere dị ka ihe isi ike na-eku ume, bronchospasm, impairment nke nsụhọ na yiri ka na-aga n'ime a Coma, na ọrịa na ụkwara ume ọkụ ma ọ bụ uche na sulfites - ruo anaphylactic ujo.

Ke adianade do, o nwere ike na-amụba sweating, oliguria, na edema ime. Neonates anọkarị mgbe hypoglycemia na acidosis.

ovadozu

Na ihe mberede, na akaghi aka nwa, ma ọ bụ na ihe banyere na-adịgide adịgide eriri akpa nwa hypertonus nwere idepụta a ọgwụ na nnukwu quantities, ọ pụrụ ime ka ngafe nke kacha kwere kwa ụbọchị dose na metụtara-ezighị ezi pụta.

Site ovadozu mgbaàmà na-agụnye: akara tachycardia afọ ime (nwa ebu n'afọ ndị dị otú ahụ a onu bụ nnọọ obere), arrhythmia, tremor na mkpịsị aka, isi mgbu dị iche iche orunótu, sweating, nchegbu, ụgha rịaworo, ala ọbara mgbali na iku ume ọkụ ọkụ. The omume nke ndị a mgbaàmà bụ ihe ndabere maka kagbuo "ginipral" ọgwụ analọg nke na-apụghị inye ndị dị otú ahụ a na-adakarị picture.

Mgbe mpụta ìhè nke ndị dị otú ahụ ihe mgbaàmà ndinọ eti ọkpọ bekee nke na-eme ka ndị na-abụghị nhọrọ beta-blockers, ike nke na-kpamkpam neutralize mmetụta nke ọgwụ ahụ.

The mmekọrịta ọzọ ọgwụgwọ bekee

Ọnụnọ nke nwanyị dị ime na-arịa ọrịa nwere ike ịchọ manye ọgwụ ọ bụghị mgbe niile dakọtara na muscle relaxant, n'ihi ya, ọ pụrụ ịbụ a ajụjụ a: "Gịnị nwere ike dochie anya" ginipral "ma ọ bụrụ na-ekpochapụ ihe ndị bụ isi ọgwụ bụ ekwe omume?"

Bekee na-egosi gbara gharịị edinam na a nkwonkwo oru nke ngwọta ma ọ bụ "ginipral" mbadamba na-agụnye:

• beta-blockers nke pụrụ ibelata ma ọ bụ ọbụna neutralize mmetụta nke "ginipral" ọgwụ ọjọọ;
• methylxanthines (gụnyere umi "Theophylline"), ime ya irè;
• glucocorticosteroids, ngụkọta mmetụta nke nwere ike belata ike nke ìgwè imeju glycogen;
• onu hypoglycemic mmadụ mgbe eji na njikọ na a ọgwụ bụ obere irè na-akpa ha ọgwụgwọ mmetụta;
• mmekọrịta nke ọgwụ na obi na bronchodilators nwere ike exacerbate mmetụta ha na ntoputa nke mgbaàmà ovadozu;
• halothane na beta adrenostimulyatorov dịkwuo ugboro nke mmetụta na obi na ndị ọzọ na ihe nke ọbara usoro;
• ergot alkaloids, Mao inhibitors, tricyclic antidepressants , na mmadụ nwere calcium na vitamin D, nakwa dị ka digidrotahisterol na mineralocorticoids, nnọọ ekwekọghị na ọgwụ ọjọọ, "ginipral" kagbuo nke na nke a dị oké mkpa.

Ebe ọ bụ na-arụsi ọrụ ike mgwa (hexoprenaline sulfate) nwere elu ọrụ, mgbe ahụ, ọ na-ekwe naanị ka izu ihe isotonic ngwọta nke sodium chloride na 5% dextrose (glucose).

Drug "ginipral": synonyms na analogues

Na-ezo aka a ìgwè nke beta-agonists, na ngwá ọrụ nwere ọtụtụ ụdị ihe na-egosi nke ọgwụ ọjọọ:

• "Partusisten" - dị ka a akpali mmasị ngwọta maka igba ogwu n'akwara ochichi na n'ụdị mbadamba, gosiri maka mgbochi nke na akaghi aka ịmụ nwa naanị na a ọgwụ.
• "Ritodrine" - eji tumadi na bronchial ụkwara ume ọkụ na ndị ọzọ okpo ọnọdụ, ma ọ bụ ike iji zuru ike na eriri akpa nwa muscle.
• "Fenoterol" - nwere a mmetụta yiri, na-eji nanị n'okpuru nlekọta nke ndị ọrụ na a ọgwụ.
• "Salbupart" - na-kenyere mgbe ihe ize ndụ nke na akaghi aka ọmụmụ na ẹkenam nnọọ nwayọọ nwayọọ intravenously karịrị otu oge nke 6-12 awa.

N'otu aka ahụ ẹsụhọde edinam eriri akpa nwa ụda nwere a Magnesia ihe igbochi calcium ọwa, n'ụzọ dị irè-eme ka ndị myometrium, na-egosipụta ihe ole na ole mmetụta.

Ọzọ ọgwụ na ike dochie ọgwụ "ginipral" - analọg nke "Indomethacin" metụtara inhibitors nke prostaglandin. Ọ bụ ike nke ọma belata ụba eriri akpa nwa ụda, ma mgbe ọ na-eji mgbe a gestation nke 32 izu mere a dị ịrịba ama ọtụtụ ndị dị oké njọ oghom mmetụta: slows nwa ebu n'afọ na akpa ume anụ ahụ maturation nwere ike ime ka jaundice na enterocolitis.

Ụfọdụ obstetricians nye iwu iji belata ụda olu nke akpanwa nkwadebe "Nifedipine". Ọ bụghị a kpọmkwem ngwá ọrụ, nke na-eji na ọrịa ụmụ nwanyị, ya akporo tumadi gbasara omume nke obi pathologies, ma dị ka a n'aka-eme ka ezigbo muscle, o nwere ike ga-eji na mwepụ nke akpanwa muscle erughị ala. Ọ ga-kwuru na ọgwụ na-akpata a ọnụ ke ọbara mgbali, nke na-egbochi nhọpụta nke ya ọrịa na hypotension.

Nyocha

Ọtụtụ ụmụ nwaanyị dị ime mara na oru nke ọgwụ na-ekwe ka wepu ihe mụbara ụda olu nke akpanwa na gbochie omume nke na akaghi aka oru. Nne onye natara ọgwụ "ginipral" na oge nke gestation, adịghị akara ọ bụla na-ezighị ezi mmetụta na-adịte nnabata nke mụrụ nwa ọhụrụ. Ọtụtụ oru nke umi aka n'ime ka ndị ka nwata a mma n'ihi ọmụmụ ya oge ya niile na akụkụ na usoro iji kwadebe maka onwe ha ndụ. Ụfọdụ nwetara a ìhè mmetụta ọjọọ n'ahụ n'ụdị a tremor nke mkpịsị aka, isi ọwụwa, na ndị ọzọ, bụ nke mere ka nwayọọ nwayọọ abolition nke ọgwụ, dị ka ọ na-apụghị inikiet inikiet otutu. Mgbanwe na ọgwụ ọhụrụ ga-ewere ụfọdụ oge, n'oge nke nwayọọ belata onunu ogwu "ginipral" mbadamba n'otu oge na-ewebata ihe ka mma ọgwụ. N'agbanyeghị ogologo ndepụta contraindications na mmetụta, na ọtụtụ na-ekwu okwu ọma, na-ekwu na-atụrụ ndụ mmetụta nke ọgwụ na muscular mgbidi nke akpanwa, nke dị mkpa karịsịa na ihe omume nke ihe mberede ọnọdụ nnwụchu nnyefe.

N'ihi ya, jiri "ginipral" na-emepụta nanị site na ịga dibịa ma ọ bụ na-eji na ụlọ ọgwụ na ikpe nke na ọnọdụ mberede metụtara omume nke na-egbu oge oru. Na nke a, ihe niile ntuziaka na-atụ aro Dosages ga-hụrụ nditịm ka ọ ghara ime ka onye ahụ nke na-akpata. Mgbe na-eji nke a ọgwụ ga-karịsịa enyịn nwetụrụ umuihe ma ọ bụ ịgbanwe ha ọnọdụ, ma ọ bụrụ na ọ dị mkpa, na a-adọ ha n'ụzọ ime ọnọdụ ruo mgbe kagbuo "ginipral" ọgwụ analogue ndị pụrụ ịghọ ihe ndị kwesịrị ekwesị na nke ọ bụla. Ọ bụ ezie na ọ ga-kwuru na elu arụmọrụ nke ọgwụ na hypertonicity nke akpanwa na ikike ngwa ngwa ebelata Mbelata nke myometrium na preterm òfùfè.