"Glibenclamide": ntuziaka maka ojiji, ntọhapụ ụdị, foto, analogs

Gịnị bụ ihe ngwọta "glibenclamide"? Ntuziaka maka ojiji, ntọhapụ ụdị, analogues na-egosi maka ochichi nke ọgwụ na-depụtara n'okpuru.

Mejupụtara, nkwakọ, ụdị tọhapụ mmadụ

Na ihe n'ụdị na-mere na nkà mmụta ọgwụ "glibenclamide"? Guide na-akọ na ndị na ngwá ọrụ na-emepụta na ụdị mbadamba nke na-enịm ke plastic containers (ndepụta nke cell) na igbe mere nke katọn, karị.

The mejupụtara nke ọgwụ n'okpuru echiche na-agụnye 5 mg glibenclamide na inyeaka Efrata dị ka nduku starch, lactose monohydrate, magnesium stearate, sodium croscarmellose, indigo carmine E 132 colloidal sịlịkọn dioxide 25, na povidone.

Drug edinam

Gịnị bụ ọgwụ "glibenclamide"? Ntuziaka maka Iji na-ekwu na nke a pụtara na-egosi hypoglycemic mmetụta ndị ahụ siri ike na ọrịa na-arịa ọrịa shuga Ụdị nke Abụọ.

Irè nke a ọgwụ ruru ya ike na-amụba insulin secretion nke pancreatic beta mkpụrụ ndụ ruru ha mmalite. Dị ka ndị ọkachamara, a mmetụta nke ọgwụ na-enwekwukwa n'okpuru nduzi nke glucose.

Kinetic atụmatụ ihe onu Nwa

Olee ihe ndị na e ji mara nke pharmacokinetic ọgwụ "glibenclamide"? Ntuziaka maka ojiji ekwu na mgbe onu dosing nke mbadamba nkume nke nọ n'ọrụ umi na-ngwa ngwa na fọrọ nke nta kpamkpam etinye obi gị dum na digestive tract.

N'otu oge nri oriri na-eduga ná a Mbelata nke glibenclamide ịta na plasma (tụnyere ihe efu afo). Na njikọ nke a akụrụngwa na albumin karịa 98%.

The ọrịa imeju glibenclamide converted n'ime ndị na-esonụ metabolites: 3-CIS-hydroxy-glibenclamide na 4-trans-hydroxy-glyburide. Ha na-mmepụta otu n'ókè site akụrụ na, ya na na nsị.

Nke pụtara iwepụ ọkara ndụ nke ọgwụ bụ 2-3.5 awa. Na ndị mmadụ na mkpọchị imeju ọrụ, a na ọnụ ọgụgụ a budata belata.

Egosi maka ojiji nke ọgwụ

Mgbe ụfọdụ, a ọrịa mkpụrụ ọgwụ "glibenclamide" nwere ike na-kenyere? Nke a pụtara nwere ike ikwu na-ewere ọrịa na-arịa ọrịa shuga Ụdị nke Abụọ, mgbe e nweghị ekwe omume iji chefuo hyperglycemia usoro iri nri na imega ahụ, ma ọ bụ arọ ọnwụ.

Bans ojiji nke

È nwere contraindications na ọgwụ "glibenclamide"? Ntuziaka maka Iji na-ekwu na nke a owuwu ekwesịghị ndinọ ka ọrịa na:

• ọtụtụ Burns;
• Hypersensitivity na-arụsi ọrụ ike akụrụngwa, na thiazide mamịrị ma ọ bụ sulfonamides;
• ketoacidosis;
• ọrịa atụbọ ma prekomatosnoe ekwu;
• mmepe nke hypoglycemia;
• ịwa ahụ na ndị ọzọ na trauma;
• gastroparesis na nsia mgbochi;
• ime;
• arịa ọrịa shuga mbụ ụdị;
• ara.

Agwọ ọrịa "glibenclamide": ntuziaka maka ojiji

Weere ọgwụ ga-ndinọ naanị nwere ahụmahụ dọkịta. A ọgwụ mgbe niile kwesịrị-achọkwa na a siri nri. Naanị na a bụrụ na ọ ga-adị irè. ya onunu ogwu na-adabere na-enwe ndidi ule results (ọbara sugar etoju, na-egosi ewepụtara mmamịrị, wdg).

Ya mere, otú na-ọgwụ ọjọọ, "glibenclamide"? Agwọ ahụ pụtara na-amalite na ntakiri doses. Nke a bụ eziokwu karịsịa nke ndị na-a ọchịchọ hypoglycemia na arọ ahụ erughị 50 n'arọ.

A, mbụ dose nke agwọ ọrịa bụ 0,5-1 mbadamba kwa ụbọchị. Nke a kwekọrọ na 2.5-5 mg n'ọrụ mgwa. Mgbe adighi ike ọgwụ edinam kpọmkwem ọtụtụ nwere ike jiri nwayọọ nwayọọ na ụba atọ mbadamba kwa ụbọchị, nke kwekọrọ na 15 mg nke nọ n'ọrụ mgwa. Nke a ga-eme na etiti oge nke a ụbọchị ole na ole ruo otu izu, ruo mgbe mkpuruedemede N'ihi na-enweta.

Otú nyefee onye ọrịa ọzọ ọgwụ na na nkà mmụta ọgwụ "glibenclamide"? The ojiji nke ọgwụ na nke a ga-rụrụ ihe ókè ịkpachara anya. First, onye ọrịa na-kenyere mbadamba 0,5 awa, na mgbe ahụ na-eji nwayọọ nwayọọ dịkwuo dose na-kasị dị irè.

Agadi na gwụ ọrịa ma ọ bụ ọrịa na erighị na mkpọchị imeju ma ọ bụ akụrụ ọrụ na-akwado ma ọ bụ na mbụ onunu ogwu nke ọgwụ na-chọrọ iwelata likelihood nke mmepe nke hypoglycemia. Ọzọkwa ikpebi na ziri ezi dose nke ọgwụ kwesịrị na usen arọ ahụ ma ọ bụ mgbe na-agbanwe agbanwe ya omenala ụzọ ndụ.

A usoro maka inweta hypoglycemic mbadamba

Olee otú iji ndị ọgwụ ọjọọ, "glibenclamide"? Ntuziaka maka ojiji (foto nke ọgwụ na-dị n'isiokwu a) na-ekwu na anya mbadamba nkume ga-emerịrị tupu nri na otu iko ẹdụk mmiri na-enweghị ịta.

Na a kwa ụbọchị onunu ogwu nke 2 mbadamba, na-atụ aro ya kee ihe agwọ ọrịa na 2 kewara doses (ụtụtụ na mgbede) na a ruru nke 2: 1.

Ọ dị oké mkpa iji nke a na nkà mmụta ọgwụ na n'otu oge ahụ. Iwepụ n'ikuku mbadamba Nwa machibidoro iwu e ọnụ na ndị na-esonụ.

Na oge nke ọgwụ na a gị n'ụlọnga na-adabere na ọrịa. Kemgbe ọgwụgwọ a chọrọ na-ebu na-aga n'ihu nlekota nke ọrịa ala nke mgbanwe bekee.

mmetụta

The agwọ ọrịa "Glibenclamide" analogs nke na-depụtara n'okpuru ebe a, nwere ike ime ka mmepe nke na-achọghị Jeremaya mere na-emetụta ndị ụjọ, endocrine, elu na digestive usoro na hematopoietic. Na nke a, ọrịa nwere ike gosi na oghom mgbaàmà ndị dị otú ahụ dị ka ọgbụgbọ, hypoglycemia ná mgbanwe nke ogo, hepatic dysfunction, afọ ọsịsa, isi ọwụwa, cholestasis, adịghị ike, dizziness na ike ọgwụgwụ.

Ọ kwesịkwara kwuru na oriri nke ndị na ngwá ọrụ na-adịghị ewepu ọdịdị dermatological na nfụkasị Jeremaya ka photosensitivity, itching, anụ ọkụ ọkụ na ndị ọzọ na wetara ihe mgbaàmà.

Ovadozu ikpe hypoglycemic mmadụ

Gịnị mgbaàmà ime mgbe elu doses nke ọgwụ "glibenclamide"? Manual na-ekwu na ihe ovadozu, onye ọrịa nwere ike ịzụlite hypoglycemia, ikekwe esonyere adịghị ike, na inwe mmetụta nke agụụ, isi ọwụwa, nchegbu, oké sweating, dizziness, muscle tremor, palpitations, ọzịza nke ụbụrụ, ọhụụ na-ekwu okwu ọrịa.

Ọgwụgwọ nke ọnọdụ ndị dị otú na-achọ ngwa ngwa mbanye glucose-digestible nri. Ka ihe atụ, ihe ọṅụṅụ mkpụrụ osisi, sugar, ọka sirop, ụtọ na-ekpo ọkụ tii ma ọ bụ mmanụ aṅụ.

Na ọzọ n'oké ikpe, onye ọrịa na-ndinọ a 50% glucose solution, "Dextrose" "Glucagon" ma ọ bụ "Diazoxide". Ọ na-na-achọ pụrụ iche akara glycemia, creatinine, urea nitrogen, electrolytes na-ekpebi onye Onyenwe anyị +.

Mmekọrịta ọzọ ike n'aka

The Nchikota nke ewere ọgwụ na-emegide systemic ọgwụ ọjọọ, tetracyclines, fluoroquinolones, chloramphenicol, Mao inhibitors, na Ace, H2-blockers, "clofibrate" beta-blockers, probenecid, bezafibrate, "paracetamol", anabolic Steroid, ethionamide, allopurinol, pentoxifylline, cyclophosphamide "reserpine", insulin na sulfonamides bụ ike potentiate hypoglycemia.

Concurrent ngwa nke ọgwụ na phenothiazines, thyroid na glucocorticoid homonụ, barbiturates, estrogens, diazoxide, progestins, glucagon, lithium salts, Adrenomimeticalkie pụtara saluretikami nicotinic acid na nkwekọrịta nwere ike imebi ya hypoglycemic mmetụta.

Dị otú ahụ formulations na-acidified mmamịrị (gụnyere ammonium chloride, calcium chloride, ascorbic acid), ike welie ihe nke na-atụle agwọ ọrịa.

The iji "glibenclamide" na "rifamycins" accelerates inactivation na belata irè nke mbụ.

kpọmkwem ozi

Hypoglycemic gị n'ụlọnga ga-atụle na-elezi anya ka ọrịa na-ata ahụhụ site na gbasara akụrụ dysfunction na imeju na, nakwa dị ka enweghị nchịkwa na thyroid na adrenal glands, febrile ọnọdụ na-adịghị ala ala aṅụrụma.

Iji mepụta nkịtị ọgwụgwọ na-achọ mgbe nile nlekota nke ọbara glucose etoju nke ọrịa, nakwa dị ka ya excretion.

Ọ bụrụ na ndị oriri nke ọgwụ ọrịa amalite hypoglycemia, na sugar họpụtara n'ime ime (na ikpe ma ọ bụrụ na ndị mmadụ bụ onye maara). Ọ bụrụ na amaghị ihe ọ bụla, glucose na-ndinọ intravenously, na glucagon - subcutaneously, intramuscularly ma ọ bụ intravenously. Mgbe onye ọrịa kpọtere elu, ọ ga-ozugbo-enye nri, ọgaranya carbohydrates, iji zere a nlọghachite nke hypoglycemia.

Na-eri na analogues (synonyms) n'aka

Họrọ analogs nke a ọgwụ ga-enwe ahụmahụ ọkachamara. N'ihi na ndị dọkịta dị ka ọgwụ ọjọọ eme ihe na-agụnye ndị na-esonụ: "Manin", "Manin", "Maniglid", "Betanaz" na "Antibet".

Ọ kwesịkwara kwuru na pharmacies mgbe ere synonyms nke ngwá ọrụ a. The kasị eji ha, "Glidanil", "Glibeks", "Glibamid", "Gilemal", "Glibomet", "glibenclamide". The onunu ogwu nke a ego a họọrọ n'otu n'otu.

Ma ihe ndị price "glibenclamide" ọgwụ ọjọọ, ọ dịgasị na nso 280-360 rubles.

Nyocha nke na nkà mmụta ọgwụ

Ugbu a, ị mara na bụ ọgwụ "glibenclamide". Ntuziaka maka ojiji, nakwa ụdị analogues nke n'aka kọwara n'elu.

Ihe ha na-ekwu banyere nke a ọgwụ ọrụ? Dị ka a na-achị, ozi niile banyere ya na-ebelata ka a ntụle nke ndị ma ọ bụ ndị ọzọ ọgwụgwọ regimens na-atụ aro ka ndị mmadụ na-arịa ọrịa shuga.

Imu na-ekwu na ọtụtụ "glibenclamide" a na-eji dị ka a monotherapy. Ọ bụ ezie na e nwere ndị na-arịa ọrịa ndị na-kenyere ọgwụ na Nchikota na ndị ọzọ hypoglycemic ọgwụ ọjọọ.

Dị ka dọkịta, nhọpụta nke ọgwụ n'okpuru echiche achọ ihe onye obibia. Na nke a, ndị ọkachamara kwesịrị maara na ihe niile na ihe chọpụtara, na ndị ọzọ ọmụmụ. Were "glibenclamide" ọrịa na ha ezi uche bụ nnọọ ize ndụ na ahụ ike, na ndụ.