"Kardosal": ntụziaka ntuziaka, reviews, nkọwa, analogs

"Kardosal" (mba aha - "olmesartan medoxomil") bụ na-eti ọkpọ nke angiotensin II ihe nnabata (ụdị AT1) - isi vasoactive hormone RAAS metụtara mmepe nke dị oké mkpa ọbara mgbali.

Ụdị hapụ ọgwụ, ya mmiri

The ọgwụ dị na mbadamba na-kpuchie site n'ọbọ. Basic umi, n'ihi na nke a agwọ ọrịa nke olmesartan medoxomil eji na mbadamba-agụnye site na 10 ruo 40 mg ( "Kardosal 10", "20 Kardosal", "Kardosal 40").

Ọzọkwa, ọgwụ e kwukwara magnesium stearate, microcrystalline cellulose, lactose monohydrate. Ọzọkwa, dị ka inyeaka koponentov eji giproloza na ala nnọchianya giproloza. Shei na-kere site titanium dioxide na kwukwara talc na hypromellose.

pharmacological mmetụta

Ọ na-chere na ọgwụ "Kardosal" na-eme na organism, na-eme ka igbochi mmetụta nke angiotensin II, _AT1 ihe nnabata onye ogbugbo. Na ọbara mgbali agwọ ọrịa lowers ọbara mgbali, otú a na-ewe ihe a ogologo oge. E nweghị ndị na data ikwado omume nke hypotension mgbe mbụ ojiji nke mbụ dose of a ọgwụ ọjọọ na tachycardia ruru ka ogologo oge ọgwụ ( "Kardosal 20", "Kardosal 40"), onye ahụ nke ndọrọ ego so a nkọ na-abawanye na ọbara mgbali.

The ojiji nke ọgwụ ozugbo a ụbọchị na-arụpụta a nwayọọ ọnụ ke ọbara mgbali egosi. The chọrọ mmetụta amalite n'elu 24 awa. A, hypotensive mmetụta a na-enweta na iri na anọ ụbọchị nke ọgwụgwọ, arụpụta ihe kasị mma hụrụ mgbe omume nke banyere ọnwa abụọ.

Pharmacokinetics

The absorption nke ọgwụ, ya nkesa

Mmanya na-egbu mbadamba ngwa ngwa ewe n'ụdị a pharmacologically ifịk metabolite na eriri afọ (n'ihi ihe dọgburu site enzymes) na portal ọbara (n'oge absorption si eriri afọ tract).

N'oge ọgwụgwọ mejupụtara ọbara plasma na-adịghị ahụrụ ifịk umi agbanweghi agbanwe. Nkezi bioavailability bụ banyere 26%. The kacha larịị nke ọgwụ dị na nkezi nke awa abụọ mgbe na-ewere ya, na-amụba onunu ogwu (otu dose - 80 mg) nke ọ enwekwu.

"Kardosal 40", nakwa dị ka ngwaahịa na dị iche iche onunu ogwu nke nọ n'ọrụ mgwa, e nwere ike iwere na-enweghị ilekwasị anya nri oriri. Iri ọ nweghị mmetụta bioavailability.

Njikọ na plasma protein bụ fọrọ nke nta zuru ezu, o kwekọrọ na 99.7%. Otú ọ dị, n'otu oge eji "Kardosala" vysokosvyazyvayuschimisya na ọgwụ ọjọọ ndị ọzọ na ọ na-n'ụzọ belata.

Drug metabolism na ya excretion si ahụ

Ihu ọma ọgwụ ewepụtara imeju (60%), na ike (40%) - akụrụ ya. Intrahepatic mgbasa nke nọ n'ọrụ umi bụ ntakịrị. Ebe ọ bụ na excretion na-emepụta tumadi site imeju, ọgwụgwọ na mmadụ "Kardosal plus" ọ na-egbu ma ọ bụrụ na ọrịa nwere biliary tract mgbochi. Mgbe ugboro ugboro ojiji nke ọgwụ ikpe egosipụta na nkezi maka 12 awa. Good mmetụta a hụrụ n'elu-anata a onunu ogwu nke ọgwụ, nke kwekọrọ na ọtụtụ doses nke "Kardosala". A ịrịba mmetụta dị ugbu a na mgbe iri na anọ na ụbọchị nke ọgwụgwọ, dịrị gaba n'ime ebe ìgwè adịghị ime. Na nke a ọnụ ọgụgụ, dị ka gbasara akụrụ nwechapụ na-adịghị emetụta dị iche iche ọgwụ onunu ogwu, ọ bụ na nso nke si 0,5 ka 0,7 L / h (ihe dị ka).

Special adakarị ikpe

Ndị ọrịa bụ ndị nọ mebiri gbasara akụrụ ọrụ (nwayọọ, agafeghị oke, oké), AUC mụbara site 62, 82 na 179%, mgbe ọnọdụ bụ anụ.

Mgbe imeju nsogbu, ubé na moderately kwuru na, otu dose AUC amụba n'aka na-enyere aka 6 na 65%.

na-agba akaebe

The oru pụtara "Kardosal" ntụziaka na ngwa na-enyere nchọpụta nke oké mkpa ọbara mgbali.

Mesoo "Kardosalom" n'oge ime bụ adịghị anakwere. Ọ bụrụ na ime bụ na ọgwụgwọ usoro, ọ dị mkpa ime ka abolition nke ọgwụ.

N'ihi enweghị data akwado nchekwa nke ọgwụgwọ nke ara na oge nke ọgwụgwọ ikwusi ara.

Iji-enwe ike ịzụta "Kardosal" na-amalite si na-emeso ya, dọkịta ga-ede a ọgwụ.

contraindications

Contraindications gụnyere hypersensitivity ndị bekee nke na-gụnyere na Nwa, na nwa (n'okpuru 18 afọ), afọ ime, ara. Ke adianade do, Erere na-adịghị kenyere ndị na-esonụ mgbe:

• mgbochi nke biliary tract;
• ọnụnọ nke malabsorption syndrome, galactosemia;
• enweghị lactase;
• oge mgbe a akụrụ transplant;
• gbasara akụrụ odida na ala QC (erughị 20 ml / min).

"Kardosal" - a ọgwụ nke na-ndinọ na oké ịkpachara anya ka ọrịa na ọnọdụ:

• akwara akwara ọrịa;
• hyperaldosteronism (isi);
• ọrịa imeju;
• gbasara akụrụ odida, nke KK ukwuu 20 ml / min;
• stenosis, lesion esonyere mitral ma ọ bụ aortic valvụ;
• ala ala obi odida eruba;
• cerebrovascular ọrịa;
• nri so mmachi sodium oriri;
• hyponatremia, hyperkalemia (e a ize ndụ nke gbasara akụrụ insufficiency, hypotension ma ọ bụ akpịrị ịkpọ nkụ);
• ala mgbe Bcc mbelata apụta vomiting, afọ ọsịsa;
• stenosis, ọkụkụ ihe akwara naanị akụrụ, bilateral stenosis, nke na-emetụta gbasara akụrụ akwara;
• hypertrophic okpo cardiomyopathy;
• afọ karịrị afọ 65;
• mkpa diuretics.

Eji "Kardosala"

"Kardosal" ntụziaka ntuziaka na-atụ aro iji 10 mg, nke kwekọrọ na mbụ dose. Mgbe ezughi oke normalisation nke ọbara mgbali ga-iwesa kwa ụbọchị 20 mg nke ọgwụ. Ngafe dose of 40 mg ọgwụ kwa ụbọchị bụ adịghị anakwere. Daily ọgwụ ga na-aṅụ otu oge, na otu oge. N'ihi na ọrịa na akụrụ nsogbu kpughere nwayọọ na agafeghị oke ogo, mgbe nwechapụ bụ na nso nke site 20 ruo 60 ml / min, karịa dose "Kardosala" nwere ike ịbụ ihe ọzọ karịa 20 mg. N'ọnọdụ ebe e nwere mkpa ka ike na n'ihi mmetụta na-emepụta mgbagwoju omume (ma e wezụga "Kardosala" ide "Hydrochlorothiazide").

mmetụta

N'ịgwọ ọgwụ "Kardosal" ntụziaka ntuziaka ekwe ka ụdị mmetụta:

• na-adịghị mma mmeghachi omume si akụkụ okuku ume na digestive usoro, ọdịdị nke na-enwe nsogbu ndị nweekwa usoro, urinary tract na-na akụrụ, na-agbanwe ụfọdụ laabu parameters, mmepe nke a n'ozuzu agwa ọrịa (dị mmetụta ime mgbe);
• mmepe nke rịaworo, ọdịdị nke ọrịa na-emetụta ndị ụjọ usoro (mgbe ụfọdụ na-egosi);
• mgbanwe ndị na-obi usoro, mmepe nke hyperkalemia (adịkarịghị hụrụ).

Mmetụta na-ebilite nnọọ adịkarịghị ke ama ọkọbọ agwọ ọrịa "Kardosal" ntuziaka maka ojiji na-agụnye:

• na-enwe nsogbu ndị hematopoietic usoro;
• ụkwara;
• nnukwu ụdị gbasara akụrụ odida;
• nsogbu akpụkpọ;
• asthenic syndrome;
• isi ọwụwa, dizziness ahụ;
• myalgia;
• convulsive ala;
• ọgbụgbọ so site vomiting, abdominal mgbu;
• abawanye nke urea, creatinine na ọbara;
• mgbanwe imeju - abawanye na ọrụ nke ya enzymes.

ovadozu

Ovadozu bụ kwere omume, ọ na-egosipụta a nnọọ Mbelata ọbara mgbali egosi. N'ihe banyere ndị dị otú ahụ a n'ihi nke ọgwụgwọ na-achọ mgbe nile nlekota nke ọrịa. Iji kpochapụ ihe mgbaàmà na-eso ovadozu pụtara "Kardosal", ndị dọkịta nwere ike ikwu na ị na-eme reviews symptomatic omume ma na-akwado ọgwụ normalize ọbara mgbali. Bụrụ na nke ovadozu ọrịa dina n'elu ya azụ na ebuli ya ụkwụ. Ke adianade do, mgbe eji a nnukwu dose nke ọgwụ na-atụ aro ịrụ gastric lavage, inye onye ọrụ carbon. E nwere mkpa maka olu nnọchi, mkpochapu akpịrị ịkpọ nkụ na nke mweghachi nke mmiri nnu itule. Ozi banyere ekwe omume nke excretion nke bekee olmesartan medoxomil site dialysis e.

adọ aka ná ntị

Na ọrịa tupu ọgwụ intensively emeso ya na diuretics na-agbaso a nri na Ewezuga oriri nke nnu, nwere ike ime ka hypotension dị ka a n'ihi nke mbụ dose ojiji nke ọgwụ. Otu N'ihi pụrụ hụrụ na ọrịa ndị na-mere vomiting ma ọ bụ afọ ọsịsa. Ihe kpatara nke a bụ mmeghachi omume nke ahu - Mbelata Bcc. Oghom omume nke a ọdịdị ga-gbochie. Ihe ize ndụ nke ya na omume a ga-atụle tupu ịmalite usoro ọgwụgwọ.

Ọ bụrụ na a onye anyajiwo akụrụ, ọ dị mkpa ka oge na-elele ndị a ọnụ ọgụgụ ahụ ọbara dị ka creatinine, potassium. The ojiji nke Ace inhibitors site ọrịa ndị a chọpụtara hyperaldosteronism (isi), bụ efu, ya mere ha anaghị nye iwu pụtara "Kardosal" (ratings egosi dịghị omume Ace inhibitors).

Buru n'uche na a siri ike iju ke ọbara mgbali na ọrịa na atherosclerosis, nke na-emetụta ụbụrụ arịa, ma ọ bụ na akwara akwara ọrịa nwere ike ime ka na mmepe nke dị ize ndụ na ọnọdụ ndị dị otú ahụ dị ka ischemic ọrịa strok na myocardial infarction.

Ọ bụrụ na mmadụ nwere ịrụ mmezi nke nyochawa mgbagwoju ígwè ma ọ bụ ụgbọala a ụgbọala, ọ dị mkpa ịmara na-ewere "Kardosala" nwere ike ime ka a na-arịa ọrịa nke ike (ike ọgwụgwụ, adịghị ike, dizziness), ọ bụ ezie na nke a na-adịkarịghị na-eme.

N'ihi na lactose ọdịnaya ọgwụ na-ewere ya machibidoro ọrịa na butere n'aka galactose ekweghị ibe nọrọ agwa. The otu na-emetụta ọrịa na malabsorption syndrome galactose na glucose, lactase erughi ke idem.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

The dọkịta ga-ede a ọgwụ na-ahụ ma ọ bụrụ na onye ọrịa na-emeso ndị ọzọ n'aka iji gbochie achọghị Jeremaya mere. Ọ na-adịghị atụ aro iji ma "Kardosalom" na ndị na-esonụ ụdị ọgwụ:

• pụtara nwere potassium;
• nnu nọ n'ọnọdụ, nke na-agụnye ndị nke potassium bụ ugbu;
• Potassium-ịhapụ diuretics;
• ọgwụ ndị na-emetụta potassium etoju ke ọbara ọbara (amụba a ọnụ ọgụgụ).

Otu ihe atụ nke ndị dị otú ahụ n'aka bụ "Heparin". Ọ bụ ike na-emetụta ndị na ọdịnaya nke potassium ke iyịp. Na-apụghị ime nke ọgwụgwọ "Kardosal" analogues enye ohere ka ya ndochi.

Ike nke antihypertensive mmetụta hụrụ mgbe ọgwụgwọ nke ọzọ antihypertensive ọgwụ ọjọọ na NSAIDs, ntụgharị mmejuputa mbara ọgwụgwọ. Agwọ na integrated obibia-agụnye iji ihe Cox-2 inhibitors, acetylsalicylic acid (kwa ụbọchị dose - karịa 3 g). Akparamagwa nke angiotensin II ihe nnabata-akụ ọkpọ pụrụ synergistically emetụta glomerular filtration site ya Mbelata.

Na n'otu oge ojiji nke ndị dị otú ahụ ka ọgwụgwọ dị ka angiotensin II ihe nnabata-akụ ọkpọ, na NSAIDs, e nwere a likelihood nke ọrịa nnukwu gbasara akụrụ odida udi. N'ihi nke a, nlekota nke gbasara akụrụ ọnọdụ na mbụ ogbo nke ọgwụgwọ a ga-rụrụ mgbe nile. Ọgwụgwọ dị otú ahụ ga-hoo haa aṅụ mmiri. Otú ọ dị, o kwere omume Mbelata ke ogo antihypertensive edinam, adịru arịa ọrịa a hụrụ ugboro ugboro irè nke ọgwụ.

Ọ bụrụ na "Kardosal" na-eji na ọgwụgwọ oge antacids, ya bụ aluminum hydroxide na magnesium, e nwere ihe ize ndụ Mbelata na bioavailability nke nọ n'ọrụ umi (agafeghị oke).

Ọ kọrọ reversible abawanye lithium etoju ke ọbara ọbara na-egosipụta na-egbu egbu Njirimara n'ihi ịdị na Ace inhibitors, angiotensin II ihe nnabata-akụ ọkpọ na ọgwụ ọjọọ nwere lithium. Na njikọ na ndị dị otú ahụ Nchikota ọgwụ ozi "Kardosalom" na ọgwụ ọjọọ, nke otu n'ime mmiri - Lithium, na-atụ aro. Otú ọ dị, ọ bụrụ na ndị dị otú ahụ a mkpa dị, akara nke ọbara kwesịrị mgbe nile.

The na-eri nke ọgwụ ọjọọ, analogs, reviews

Mgbe na-ekenye "Kardosal" mbadamba ka price bụ ndị ọrịa nile, ya mere, ha nwere mmasị ekwe omume nke ọgwụgwọ na ojiji nke ọzọ, irè n'aka. "Kardosal" na ọdịnaya nke 10 mg nke nọ n'ọrụ mgwa nwere ike zụrụ maka ete 610, a ọgwụ nke ndị mejupụtara nwere 20 mg nke nọ n'ọrụ mgwa -. N'ime 756 ite. "Kardosal", onye price bụ banyere 860 rubles., Nwere 40 mg nke isi akụrụngwa.

Dị ka ihe ntụnyere, mgbe ị na-ahọrọ ụzọ ọzọ nke mmejuputa iwu-nke ọrịa, kama "Kardosala" i nwere ike na-etinye na nkà mmụta ọgwụ "Olimestra" ma ọ bụ na-emepụta a Nchikota ọgwụ dabere na ojiji nke "hydrochlorothiazide", "olmesartan medoxomil". Ị nwere ike iri uru nke ndị dị otú ahụ na ndị ọgbọ dị ka "Lozarel 'ma ọ bụ' Cozaar '. Ke adianade do, maka nnọchi nke kwesịrị ekwesị ọgwụ ọjọọ "Nortivan" "Valsartan Zentiva".

Aware nke ndị dị otú formulations dị ka "Olmesar", "Plaunak". Na-emekarị nọ n'ọnọdụ dị iche si mbụ ego, onye nke ọzọ bụ ihe ezi uche price ma belata bioavailability kwa, otú a ka ha na-erughị irè, ọ bụ ezie na ọ pụrụ ịnagide ọrụ.

Analogs na-mgbe na-eji n'okpuru elekọta ya mgbe nile nke a ọkachamara, ọ dị mkpa ka mgbe niile na-elele ọbara mgbali. Ọ bụrụ na ị chọrọ ka bulie analogue na owuwu "Kardosal" karịa dochie a ọgwụ, dọkịta kpebie, ewere n'ime akaụntụ dị iche iche oge. N'elu nchọpụta nke oghom ihe n'oge ọgwụgwọ oge na analogue kwesịrị ime ka ọ dị mkpa na omume na a-adọ ha n'ụzọ na-iji na ha mkpochapu. N'oge ọgwụgwọ ọ dị mkpa iji chọpụta mmetụta na ahu.

Mgbe mbụ enweghị agbanwe ngwaọrụ-apụghị ime, ga-enye mmasị na ọgwụ ọjọọ arụpụtara site European ụlọ ọrụ na-anwale. Mgbe atụmatụ dochie "Kardosal" mbadamba analogues nnọọ na ị ga-ahọrọ ndị kasị mma.

Comments ekpe na dọkịta-ndidi forums, na-egosi na ọgwụ "Kardosal" n'oge ọgwụgwọ na-akpatakarị oghom Jeremaya mere, ndị kasị nke - na obi mgbu na mgbe nile ike ọgwụgwụ. Ma, n'agbanyeghị na ndị a wetara oge, na hypotensive mmetụta bụ mgbe magburu onwe. Ọdịdị nke oghom mmetụta na-achọ Ntuziaka ka a ọkachamara maka ndụmọdụ, na ike ịgbanwe ọgwụgwọ Usoro.

N'ịgwọ ndị ọrịa ndị a chọpụtara na ha nwere ọbara mgbali elu, ọ dị mkpa inye onye ọrịa nlekota mgbe niile. Ndozi usoro ọgwụgwọ, ya mere, ga-enye ohere inweta mmetụta dị mkpa ma nyochaa steeti ahụ, ma ọ bụrụ na nchọpụta nke mmebi - na oge iwepụ ha. Otu ụzọ dị mkpa dị mkpa, naanị ọgwụgwọ ọgwụ adịghị ezuru, anyị ka kwesịrị ịhọrọ nri pụrụ iche. Otu n'ime usoro ọgwụgwọ dị mkpa bụ imebe usoro nkwụsị nke ọrụ, iwepu àgwà ọjọọ, na-egbochi ike ịkpụ ahụ na ịhụ ndụmọdụ ndị ọzọ dọkịta nyere maka ọgwụgwọ kachasị mma.