"Nwepụ Ụgha": ntụziaka maka ojiji. "Ife aka na-eme": ọgwụgwọ, akaebe, ihe ngosi, contraindications

Ị ma ihe na-enyere ọgwụ dịka Losek MAPS aka? A ga-akọwa ntuziaka maka ojiji, yana nkọwa nke ọgwụ a n'isiokwu a. Tụkwasị na nke a, anyị ga-agwa gị ihe nke a pụtara bara uru, ma ọ nwere ihe analogues na contraindications, mmetụta ndị dị aṅaa na-eme mgbe ị na-ewere ya na ihe ndị ọzọ.

Ngwakọta, nkwakọ ngwaahịa na ụdị nkwadebe

Kedu ọgwụ bụ "Losek MAPS"? Ntuziaka maka iji gwa anyị na nkwadebe a dị naanị n'ụdị mbadamba. Ihe mgbochi nke ọgwụ bụ omeprazole (10, 40 ma ọ bụ 20 mg). Ọzọkwa mbadamba na-agụnye na inyeaka Efrata: glyceryl monostearate, MCC, hydroxypropylmethylcellulose, hydroxypropylcellulose, magnesium stearate, sugar, methacrylic acid, talc, paraffin, triethyl citrate, polyethylene glycol, titanium dioxide, polysorbate, ígwè oxide, crosslinked polyvinylpyrrolidone na sodium stearyl fumarate .

Ị nwere ike ịzụta ọgwụ na vials nke 14, 7 ma ọ bụ 28 mbadamba (10, 40 ma ọ bụ 20 mg), tinye na igbe igbe.

Pharmacodynamics

Kedu ka ọgwụ Losek MAPS si arụ ọrụ? Ihe ntụziaka maka iji kwuo na nkwadebe a bụ onye na-emechi H + -K + -ATPase. Ọzọkwa, ọ na-ezo aka na ọgwụ ọjọọ. Ya nọ n'ọrụ gị n'ụlọnga bụ a na-adịghị ike isi. Ọ na-atụkwasị na gburugburu acidic nke mkpụrụ ndụ parietal nke ụyọkọ mucosa site na ịrụ ọrụ na igbochi proton mgbapụta.

Mmetụta nke omeprazole na usoro a kọwara bụ dose-dabere. Ọgwụ ahụ nwere ike ịmepụta nkwụsị dị irè nke ihe na-akpali akpali na basal nke hydrochloric acid n'agbanyeghị ihe na-akpali akpali.

Mmetụta na secretion nke gastric ihe ọṅụṅụ

N'iji nri ọnụ kwa ụbọchị, ọgwụ "Losek MAPS", nke a ga-enyekwu ntakịrị ntakịrị ihe, na-enye ihe ngbochi dị irè na ngwa ngwa nke ọrụ nzuzo nke ehihie na ụbọchị nke hydrochloric acid. A na-ahụ mmetụta ọgwụgwọ kachasị mma n'ime ụbọchị 4 nke ọgwụgwọ. N'ime ndị nwere ọnyá afọ duodenal, 20 mg nke ọgwụ na-eme ka ọnụ ala na-adị na 24 hour gastric acidity site na ọ dịkarịa ala 80%. Ekwesiri iburu n'uche na onu ogwu a nwere ike ijide onu ogugu acho> 3 n'ime gburugburu intragastric. Mmetụta a na-adịgide ruo awa 17.

Mmetụta na Helicobacter pylori

Kedu ka ọgwụ ahụ bụ "Losek MAPS" dị irè maka nje ahụ? Ntuziaka ahụ, tinyere ọgwụ, kwuru na omeprazole nwere mmetụta bactericidal dị elu na Helicobacter pylori. Nditre bacteria n'oge ngwa pụtara na Nchikota na-emegide nje ọgwụ ọjọọ na-esonyere pụtara ngwa ngwa ebibi ndị nile na mgbaàmà, nakwa dị ka a elu ogo na-agwọ ọrịa nke emetụtara mucosa nke digestive tract. Tụkwasị na nke ahụ, ọgwụgwọ dị otú ahụ na-eme ka ndị mmadụ kwụsị mgbatị nke ọrịa nhụjuanya, bụ nke na-ebelata ohere nke ọbara ọgbụgba ugboro ugboro.

Njirimara ndị ọzọ nke nkwadebe

Kedu ihe ndị ọzọ na ọgwụ dịka Losek MAPS nwere? Ndị ọkachamara na-ekwu na ndị ọrịa na-anọchi anya ma jiri ogologo oge na-aṅụ ọgwụ ọjọọ nke na-ebelata ọgwụ nke glands nke tractes digestive, na-adịkarị mgbe cysts glandular na afo. Dị ka a na-achị, ha dị njọ ma na-agafe onwe ha.

Ndaba na secretion nke hydrochloric acid na afo na-akwalite eriri microflora. Otú ọ dị, nke a nwere ike ibute obere mmụba n'ihe ize ndụ nke ibute ọrịa.

Nye ndị okenye na ụmụaka ndị weghaara ọgwụgwọ a ruo ogologo oge, a na-ahụwanye ọnụ ọgụgụ mkpụrụ ndụ nke enterochromaffin.

N'oge ọgwụgwọ na omeprazole, ọnyà nke gastrin n'ime ọbara na-aba ụba.

Pharmacokinetics

Ọ bụ ọgwụ "Losek MAPS" na-etinye aka n'ọbara? Ntuziaka iji mee ihe na-ekwu na absorption nke omeprazole na-apụta n'ime eriri afọ (maka awa 4-6). A naghị emetụta ingestion nke nri na bioavailability nke ihe a. Mgbe nlekọta ọnụ, ọ dị ihe dịka 60%.

Ọgwụ a na-emeju na imeju. Ọkara ndụ dị ihe dịka 30-80 nkeji. Ihe dị ka pasent 80 nke ihe na-arụsi ọrụ ike na-eme ka akụrụgwụ ghara ịmalite na metabolites, na ihe fọdụrụnụ yana feces.

Ntu

Isiokwu "Losek MAPS" wepụta ihe ndị na-esonụ:

• Akwa afọ;
• Reflux-esophagitis;
• Ulcer duodenum;
• Egwu nke eriri afọ nke eriri afọ nke mbido NSAID;
• Akwụsị Helicobacter pylori;
• Dyspepsia, nke ejikọtara na ụba acidity;
• Ọrịa reflux gastroesophageal (symptomatic);
• Ahụhụ Zollinger-Ellison.

Contraindications

A gaghị eji ọgwụ "Losek MAPS" mee ihe maka ndị ọrịa nwere hypersensitivity na omeprazole, nakwa dị ka benzimidazoles ma ọ bụ ndị ọzọ na-emepụta bụ akụkụ nke ọgwụ.

Ekwesiri iburu n'uche na a na-eji nlezianya na-enye ndị mmadụ ihe nrịba ama dịka ọnwụ, dysphagia, nsị na vomiting na ọbara. Ọzọkwa, na gastric ọnyá afọ (ma ọ bụ enyo enyo ọrịa) ga ewepu ọnụnọ nke a ajọ akpụ. Nke a bụ n'ihi na ọgwụgwọ na omeprazole nwere ike imebi mgbaàmà nke ọrịa ahụ n'ụzọ dị mfe ma kwụsị oge ịchọta nchoputa ziri ezi.

Kedu ka esi eji ọgwụ "Losek MAPS" (20 mg)?

A ghaghị iwere ya n'ụlọnga n'ụtụtụ. A ghaghị ilocha ọgwụ ahụ dum, saa ya mmiri. Nkwadebe ekwesịghị ikwe ya ma ọ bụ ata ya.

A na-ekwe ka mbadamba na-agbaze n'ime mmiri mmiri ma ọ bụ mmiri, dịka ọmụmaatụ, (dịka ọmụmaatụ, na mkpụrụ osisi na-amị mkpụrụ). Otú ọ dị, a ghaghị ịṅụ mmanya na-aba n'anya n'ime ọkara awa.

Na reflux esophageal, ọnyá afọ, nakwa 12 duodenum, a na-etinye ọgwụ ahụ ọgwụ 20 mg kwa ụbọchị. Site na reflux-esophagitis, a na-agbatị okpukpu abụọ ahụ.

Ogologo ọgwụgwọ maka ọrịa ọnya bụ izu 2-4, na reflux-esophagitis - izu anọ, na reflux gastroesophageal - izu 4-8. Iji gbochie nlọghachi nke ọnya na reflux esophagitis, a ga-etinye usoro ogologo nke dose mg 10 mg.

Mmetụta dị na ya

Nje ọgwụ "Losek MAPS", ọgwụ ana-ekwu banyere ọgwụ ọjọọ nwere ike ịkpata mmetụta ndị ọzọ. Ugboro ugboro bụ ọnọdụ ndị na-esochi ọrịa: isi ọwụwa, flatulence, mgbu abdominal, afọ ntachi, afọ ọsịsa, ọgbụgbọ na vomiting.

Mmetụta utịp na-agụnye: dermatitis, hives, dizziness, itching, paresthesia, rash, malaise, ụra, ịrụ ọrụ nke imeju enzymes na ehighi ura.

Kama obere na ọrịa na-anata omeprazole ibili hypersensitivity Jeremaya mere (e.g., anaphylactic ujo, fever, anaphylaxis, angioneurotic edema), na bronchospasm, ịba ọcha n'anya, muscle adịghị ike, hepatic ọdịda, leukopenia, encephalopathy, arthralgia, ịda mbà n'obi, myalgia, pancytopenia, thrombocytopenia, n'ahụhụ, agranulocytosis, akọrọ ọnụ, hyponatremia, eriri afọ candidiasis, ime ihe ike, photosensitivity, mgbagwoju anya na bịara ikiri ọhụụ, ịmụ anya arọ nrọ, sweating, uto nsogbu, Periph -geometric edema, stomatitis, interstitial nephritis, alopecia, gynecomastia, erythema multiforme, microscopic afọ, Stevens-Johnson syndrome na-egbu egbu epidermal necrolysis.

Ọ dịtụghị anya hypocalcemia, hypomagnesemia, hypokalemia na hypomagnesemia.

Edozi elu: ọnụahịa na usoro ihe atụ

E jiri ya tụnyere ọgwụ ndị yiri ya, ọnụahịa nke ọgwụ ndị a jụrụ ajụjụ dị elu. Ya mere, maka 14 mbadamba ị ga-enye banyere 250 Russian rubles. N'iji ọgwụ na-eme ogologo oge (izu 2 ruo 8), ọgwụgwọ dị oke ọnụ maka ha.

Kedu ihe bụ ihe nnọchiteanya maka ọgwụ ọgwụ "Losek MAPS"? Analogues nke ngwá ọrụ a nwere otu arụmọrụ. Otú ọ dị, tupu i jiri ha, ị ga-agakwuru dọkịta mgbe niile.

Ya mere, ị nwere ike dochie ọgwụ "Losek MAPS" na ọgwụ ndị a: Omeprazol-Acry, Vero-Omeprazole, Cisagast, Gastrozol, Helol, Demeprazole, Helicid, Zhelkizol, Ultop "," Zerocid "," Ulkozol "," Zolser "," Ulzol "," Krismel "," Sopral "," Losek "," Romesque "," Omez "," Kwuokwa "," Omez D " 20, Omez Insta, Pepticum, Omezol, Otsid, Omekaps, Ortanol, Omeprazol, Omitox, Omeprazol-Richter, Omipix, Omeprazol Stada , Omizak, Omeprazol Zentiva, Omefez, Omeprazol Sandoz, Omeprus, Omeprazol-OBL, Omeprazol-FPO , "Omeprazol-Teva", "Omeprazol-AKOS".

Nyocha Nta

Kedu ihe ndị ọrịa na - ekwu maka ọgwụ "Losek MAPS"? Nyocha gbasara ngwá ọrụ a dị oke mma. Dị ka ndị na-ebi na-e kwuru agwọ ọrịa, ọ na-ezi ihe n'ụzọ dị irè na-ewepu niile ihe mgbaàmà nke acidity nke gastric ihe ọṅụṅụ. A na-achọpụtakwa ihe ọ rụpụtara obere oge ozugbo ọ nara mbadamba nkume ahụ (mgbe 1-2 awa).

Ọtụtụ mgbe, a na-eji ihe ngwọta maka nrịkasi obi na ihe na-enwu ọkụ n'azụ sternum.

N'agbanyeghị na ọgwụ ọjọọ dị irè, ọtụtụ ndị ọrịa na-eme mkpesa na mgbe ha kwụsịrị ikuku ya, mmetụta ndị na-adịghị mma ga-alọghachi azụ. N'okwu a, ndị dọkịta na-akwado ọgwụgwọ zuru ezu ma jiri ọgwụ ahụ mee ihe ma ọ dịkarịa ala izu anọ.