Ọgwụ "Remicade": ntuziaka maka ojiji, n'ezie na

Ọma pụtara "Remicade"? Ntuziaka maka ojiji, ndidi reviews nke a na nkà mmụta ọgwụ ga-ọkọnọ n'okpuru. Ọzọkwa n'isiokwu a, ị ga-amụta banyere ihe ọ bụla ikpe, nye iwu ọgwụ, ma ọ nwere contraindications na oghom mmetụta, nke mmiri bụ akụkụ nke ya na na.

Ụdị, mejupụtara

Nkwadebe "Remicade" na-agbala n'ụdị a lyophilized powder zubere maka nkwadebe nke infusion ngwọta. The n'ọrụ mgwa nke ọgwụ bụ infliximab. Ọ na-e dere ọzọ mmiri ka polysorbate 80, sodium hydrogen phosphate dihydrate, sucrose na monohydrate sodium dihydrogen phosphate.

Key Njirimara

Gịnị bụ na nkà mmụta ọgwụ "Remicade"? Ntuziaka maka Iji na-ekwu na ọ bụ ihe immunosuppressive n'ụlọnga.

Etinyewe n'ime ahụ, na ọgwụ na-amalite na-emekọ na soluble na transmembrane forms of akpụ necrosis Alfa (TNFα), mbenata ha ọrụ site guzobere a ufọk ufene mgbagwoju.

Research ọkachamara na-atụ aro na-arụsi ọrụ ike iji ọgwụ umi ebelata cellular infiltration (mkpali), ọnụ ọgụgụ nke ndị mkpali nrịbama na otụk ebe nke eriri afọ. N'ihi ya, ọ pụtara ngwa ngwa na-agwọ ọrịa nke mucous akpụkpọ ahụ.

Pharmacokinetics

Gịnị bụ pharmacokinetic kwa ka nkà mmụta ọgwụ "Remicade"? Note, nzaghachi kwuo na a otu igba ogwu n'akwara ntụtụ infliximab ke ichekwa ruo 20 mg / n'arọ sochiri a proportional abawanye na ya kacha ịta.

Ugboro ugboro ngwa nke ọgwụ na-akpata a nta ìgwè nke nọ n'ọrụ umi ke ọbara.

Ụzọ nke mkpochapu nke ọgwụ na a mata.

egosi

N'ihi na ihe na nzube nwere ike họpụtara ọgwụ "Remicade"? The eji nke a ọgwụ na-egosi na ndị na-esonụ mgbe:

• Ọrịa ogbu ogbu na nkwonkwo na-arụsi ọrụ ike ụdị (ma ọ bụrụ na-emeso ndị ọrịa isi antiinflammatory ọgwụ ọjọọ bụ adighi ike). Agwọ e rụrụ na Nchikota na "methotrexate". Nke a Nchikota-enye ohere maka mbenata ihe ịrịba ama nke ọrịa, nakwa dị ka mma nke na nkwonkwo dị ka a dum.
• Crohn ọrịa na okenye ọrịa. Na nke a na ọ na-enyere aka "Remicade"? Guide na-ekwu na ọgwụ na a nkwadebe ga-mụụrụ bụrụ na nke ekweghị ibe nọrọ ma ọ bụ adịghị irè, ma na contraindications ọkọlọtọ ọgwụ. N'ọnọdụ dị otú nchoputa "Remicade akwalite ebibi ndị nile na ọrịa mgbaàmà, ịnọgide na-enwe ngbaghara na ngwa ngwa na-agwọ ọrịa nke ọnyá, fistula mmechi ma melite ọrịa na-arịa.
• Crohn ọrịa na-eto eto. Ọgwụgwọ na a ọgwụ a rụrụ bụrụ na nke ekweghị ibe nọrọ ma ọ bụ adịghị irè, ma na contraindications ọkọlọtọ atụmatụ nke ọgwụ. Agwọ ọrịa "Remicade" ebelata mgbaàmà na-akwado ngbaghara na mma na àgwà nke ndụ nke na-eto ọrịa.
• Ọnyá afọ okenye. Drug "Remicade", nke Nyocha gosiri n'okpuru, na-ndinọ ke edinam na ot ọgwụ bụ adighi ike. Ọgwụgwọ nke a gị n'ụlọnga na-ebelata ihe mgbaàmà nke ọrịa, nsia mucosa na-agwọ ọrịa, gụnyere ma ọ bụ ekpochapụ GCS Dosages. Ọ kwesịkwara kwuru na, mgbe e kenyere nke ngwá ọrụ eliminates mkpa a ọgwụ na ọnụnọ.
• Ọnyá afọ na ụmụ. Ọgwụgwọ na a ọgwụ kenyere ụmụ noo 6-18 afọ, ma ọ bụrụ na ama adighi ike ot ọgwụ.
• Ankylosing spondylitis (na ọkọlọtọ ọgwụ inefficiency). Dị ka nchoputa na-enyere na nkà mmụta ọgwụ "Remicade"? Ntuziaka maka ojiji na-akọ na ngwá ọrụ a na-ebelata ihe ịrịba ama nke ọrịa na mma ịrụ ọrụ nke nkwonkwo.
• Psoriasis (na ọkọlọtọ ọgwụ inefficiency). Dị ka psoriasis enyere "Remicade"? Ọbịa ọkachamara na-ekwu na a ọgwụ na-ebelata mbufụt ke akpụkpọ apụta ihe na usoro nke keratinocyte iche.
• Psoriatic ogbu na nkwonkwo (maka ọkọlọtọ ọgwụ inefficiency). The agwọ ọrịa "Remicade" ndinọ na Nchikota na "MTX" ma ọ bụ dị ka monotherapy na contraindications ma ọ bụ ekweghị ibe nọrọ na nke ikpeazụ. N'ihi ya, na ọgwụgwọ belata mgbaàmà nke ogbu na nkwonkwo, ọrịa mma ọtọ ọrụ, nakwa dị ka mbelata ogo radiographic progression na psoriatic ogbu na nkwonkwo.

contraindications

Ọgwụgwọ "Remicade" machibidoro omume mgbe:

• oké nje usoro (e.g., sepsis, etuto, ụkwara nta, opportunistic nje) ;
• ụba uche nke onye ọrịa na infliximab na murine edozi na ihe ọ bụla ọzọ mmiri nke ọgwụ;
• n'okpuru afọ 6 afọ (ọnyá afọ na Crohn ọrịa);
• ime;
• obi odida;
• n'okpuru afọ 18 afọ;
• ara.

Drug "Remicade": ntuziaka maka ojiji. Na ebe ka itinye (ma ọ bụrụ na naanị na ụlọ ọgwụ)?

E lee ya anya ọgwụ ga-ndinọ naanị n'okpuru nlekọta nke a ọkachamara (ie ọgwụ) onye nwere a zuru ezu ahụmahụ nke nchoputa na ihe ịga nke ọma ọgwụgwọ nke n'elu ọrịa.

The ngwọta na ẹkenam dropwise intravenously n'elu 120 nkeji. The ọnụego ekwesịghị ịbụ elu karịa 2 ml kwa nkeji. Mejuputa usoro dị mkpa na-eji nke infusion usoro.

The onunu ogwu nke ọgwụ na-adabere na-egosi.

ọrịa ogbu ogbu na nkwonkwo

N'ọnọdụ dị otú nchoputa ọrụ mbụ dose kwesịrị banyere 3 mg kwa n'arọ. The agwọ ọrịa na-ndinọ ugboro ugboro na 3-6 izu. Mgbe na-eji ya kwa ọnwa abụọ.

Na omume na ọgwụgwọ mmetụta bụghị e enweta, na-atụle ndị nchupu nke ọgwụ.

Abụkarị ọgwụ bụ "Remicade" na ọrịa ogbu ogbu na nkwonkwo ndinọ ọnụ na "methotrexate".

ọnyá afọ

Mbụ onunu ogwu mgbe ndị dị otú ahụ nchoputa bụ 5 mg kwa n'arọ ahu aro. Otu dose ọgwụ na-ndinọ 3-6 izu ka e mesịrị. Mgbe ahụ agwọ ọrịa rụrụ ọ bụla ọnwa abụọ.

Ọ bụrụ na ọ dị mkpa, ndị dose nwere ike mụbara ka 10 mg kwa n'arọ. Mmetụta nke ọgwụgwọ a na-emekarị hụrụ n'ime 14 izu. Na ikpe, ma ọ bụrụ na ọ bụghị, ị ga-anọgide na ọgwụgwọ.

psoriatic ogbu na nkwonkwo

Psoriatic ogbu na nkwonkwo ọgwụ "Remicade" ndinọ na mbụ dose of 5 mg kwa n'arọ. The agwọ ọrịa na-ndinọ ugboro ugboro na 3-6 izu. Mgbe na-eji ya kwa 7-8 izu.

Idepụta ọgwụ nwere ike ikpokọta na "methotrexate".

Crohn ọrịa

N'ọnọdụ dị otú nchoputa n'ihi na ndị okenye na-egosi otu doses of 5 mg kwa n'arọ. Ọ bụrụ na ndị ọgwụgwọ mmetụta bụghị e enweta maka gara aga 2 izu, ọgwụ agbanwe.

Ọ bụrụ na a mma ọgwụ eme ihe, ndị na-esonụ atụmatụ:

• The ngwọta e ndinọ ke otu dose ka na mbụ infusion, na mgbe 3-6 izu reused. Mgbe ahụ, na-eme ka ndị injections ọ bụla ọnwa abụọ. Ọ bụrụ na chọrọ, ndị dose nwere ike mụbara ka 10 mg kwa n'arọ.
• The ọgwụ na-ndinọ naanị na nlọghachi bụrụ na ọ bụghị tọrọ 16 izu mgbe mbụ were.

Crohn ọrịa na-eto eto ụmụ

Crohn agafeghị oke ma ọ bụ oké na ụmụ n'okpuru 18 afọ-agụnye iji ihe mbụ dose of 5 mg kwa n'arọ. Ụdi injections ga-eme na 3-6 izu. Mgbe ahụ ọgwụ na-eji ọ bụla ọnwa abụọ ma ọ bụrụ na achọrọ, agbazi ka a onunu ogwu nke 10 mg kwa n'arọ.

A, ọgwụ na-achọkwa na immunomodulators 6-mercaptopurine, "azathioprine" ma ọ bụ "methotrexate". Ọ bụrụ na ndị ọgwụgwọ mmetụta bụghị e enweta (maka 10-11 izu), na ojiji nke ọgwụ ọjọọ bụ ekwesighi.

Crohn ọrịa na-esonyere fistula

A otu dose nke ọgwụ ndị dị otú ahụ nchoputa bụ 5 mg kwa n'arọ (okenye). Ọgwụ reused mgbe 3-6 izu. Ọ bụrụ na ndị ọgwụgwọ mmetụta mgbe 3 injections na-adịghị hụrụ, mgbe ahụ, ihe ọzọ ọgwụgwọ bụ na-ekwesịghị ekwesị.

Na mmetụta dị mma nke ọgwụ, ndị na-esonụ atụmatụ:

• reintroduction mgbe 3-6 izu na mgbe ọ bụla ọnwa abụọ;
• na agwọ ọrịa amịnye nlọghachi azụ ma ọ bụrụ na o were ihe na-erughị 16 izu.

ankylosing spondylitis

Dị ka nchoputa ọgwụ ọjọọ "Remicade"? Ntuziaka maka ojiji na-ekwu na na ọrịa a na mbụ onunu ogwu nke ọgwụ kwesịrị 5 mg kwa n'arọ. Mgbe nke a, ọgwụ na-ndinọ mgbe 3-6 izu.

Ọgwụgwọ-ekwesịghị iso ma ọ bụrụ na, n'ime izu isii mmetụta bụghị kwesiri ngosi.

psoriasis

Na ọgwụgwọ nke psoriasis amalite dose bụ 5 mg ọgwụ kwa n'arọ. Ugboro ugboro ngwa nke agwọ ọrịa ndinọ mgbe 3-6 izu, na mgbe ahụ na - ozugbo ọ bụla asatọ izu.

Usoro maka nkwadebe nke infusion ngwọta

The ngwọta ga-kwadebere dị ka ndị a:

• Ọ wepụtara na dose na ọnụ ọgụgụ nke vials.
• The ọgwụ powder e etisasịwo ke 10 ml nke mmiri mmiri iji a ntụtụ. Iji mee nke a, wepụ ihe mgbaze mkpọ okpu (plastic), hichaa ihe igbochi na-aba n'anya. The agịga na-etinyere site ya center, na ọmụmụ na-eduzi site na mgbidi.
• The ngwọta e ọma kpaliri (rotational ije) rue powder na-etisasịwo. Drug mmiri mmiri ga-abụ ma colorless ma ọ bụ odo tint. Ọ bụrụ na n'oge agwakọta mkpọ ụfụfụ kpụrụ, ọ dị mkpa inye a ngwọta nke 5 nkeji. The ikpeazụ onunu ogwu forms nwere ike ịbụ ugbu translucent iwu ahụ.
• Mkpokọta olu nke ọgwụ na-agbazi ka 0,9% chloride (250 ml) nke sodium ngwọta. N'ihi nzube a njikere mmiri mmiri na-agbakwunyere na karama, nke ugbua nwere sodium chloride. Ma mmiri na-juputara weere.
• Okwu Mmalite nke nkwadebe a rụrụ bụghị mgbe e mesịrị ka 3 awa mgbe nkwadebe nke ọgwụ ngwọta.

Ọ a machibidoro iwu tinye ọgwụ na ndị ọrụ ọzọ site n'otu usoro. Ọ bụrụ na e nwere ndị mba ọzọ ihe ma ọ bụ opaque ahụ na ihe ngwọta, ọ na-adịghị atụ aro.

Ejibeghi ego nke ọgwụ na ike tinye n'ọrụ.

mmetụta

Mgbe iji agwọ ọrịa, ndị na-esonụ n'akụkụ Jeremaya mere:

• ịda mbà n'obi, enweghị mmasị, inwekwu nchegbu, dizziness, somnolence, ịma jijiji, obi nchefu, psychosis, isi ọwụwa;
• akpa ume edema, Sinusitis, bronchoconstriction, dyspnea, nfụkasị Jeremaya, oyi baa, epistaxis, bronchitis, pleuritis;
• conjunctivitis, keratoconjunctivitis, endophthalmitis;
• ọkọ na urinary tract-efe efe;
• tides, nsogbu nke elu mgbasa, bradycardia, ecchymosis, hematoma, vaskụla apịajighị apịaji, syncope, palpitations, cyanosis, petechiae, arrhythmia;
• thrombocytopenia, anaemia, neytrotsitopeniya, leykotsitopeniya, lymphopenia, lymphadenopathy, lymphocytosis;
• cheilitis, afọ ntachi, cholecystitis, reflux, diverticulitis, afọ ọsịsa, ọgbụgbọ, afọ mgbu, mkpọchị imeju ọrụ;
• akpụkpọ ọkụ ọkụ, akọrọ anụ ahụ, alopecia, seborrhea, itching, abrasions, ọkụ ọkụ, ọsụsọ na-agba mụbara, dermatitis, fungal, waatị, hyperkeratosis, erysipelas, a mebiri nke anụ pigmentation, bullous ọkọ.

Nyocha nkwadebe

Ugbu a ị maara otú e si eji ọgwụ ọjọọ, "Remicade". Ntuziaka maka ojiji nke ọgwụ ọ bụla a kọwara n'elu.

N'ọnọdụ ka ukwuu, na-ewere a-esi nagide ọrụ. Ya mere, nzaghachi si ọrịa chọpụtara ukwuu n'ime mma. Ndị na-eji nke a ngwọta, na-akọ na mgbe ntụtụ mgbu fọrọ nke nta kpam kpam. Otú ọ dị, ụfọdụ ndị ọrịa na-atụ egwu na nduzi, ọ pụrụ ime ka.