"Osterepar": ntụziaka ntuziaka, reviews, emeputa, analogues

Mbenata larịị nke minerals na ọkpụkpụ anụ ahụ na-akpata nnukwu ego nke mmebi nke ọkpụkpụ na articular ngwa na ndị mmadụ n'otu n'otu nke dị iche iche afọ iche iche. Ọtụtụ mgbe, ọkpụkpụ njupụta mbelata n'ihi ụba ọkpụkpụ mgbaji ọkpụkpụ - na-akpọ ọkpụkpụ resorption. The normalisation nke n'ahụ Filiks n'etiti mbibi na e kere eke nke ọkpụkpụ - isi ihe mgbaru ọsọ nke ọgwụgwọ nke ọrịa nke ụdị. Otu n'ime ihe ndị ọgwụ ọjọọ eme ihe maka ọgwụgwọ nke osteoporosis, bụ "Osterepar". Ka anyị hụ ihe ha na-ekwu banyere "Osterepar" nkwadebe ntuziaka maka ojiji, n'ezie na dọkịta na ndị ọrịa.

pharmacological akparamagwa

N'ọrụ umi nke nkwadebe "Osterepar" bụ alendronic acid, nke na-anọchi anya na ụdị nke sodium nnu - sodium alendronate. The usoro nke ihe nke a umi bụ n'ụzọ zuru ezu nchọpụta, Otú ọ dị ya na-mara na endpoint nke alendronate sodium ikpughe bụ iweghachi a mma itule n'etiti mbibi na mweghachi nke ọkpụkpụ anụ ahụ. Part nke usoro a na-ghọtara site inhibiting osteoclasts - pụrụ iche ọkpụkpụ mkpụrụ ndụ maka mbibi ya.

Ọzọkwa, ọ na a maara na Mbelata nke plasma calcium na-akpata ya ìgwè ke ọkpụkpụ anụ ahụ mgbe na-ewere ọgwụ "Osterepar". Ntuziaka maka ojiji na-ekwu ọ na-eme ka ọkpụkpụ Ọdịdị na belata ihe ize ndụ nke fractures.

The pharmacokinetic e ji mara

N'agbanyeghị eziokwu na alendronate sodium bụ ngwa ngwa soluble n'ime mmiri na okenye agbanwe agbanwe, ọgwụ absorption si nsia lumen bụghị a mma - na absorption bụ naanị banyere 25%. Ọ maara na "Osterepar" mara ezigbo mma ejikọ na plasma-edozi (na-adịgide adịgide ogo bụ 70-75%) na-adịghị metabolized ke idem.

Egosi "Osterepar" nkwadebe

Ntuziaka maka ojiji na-ekwu na ọgwụ gosiri maka deforming ọkpụkpụ ọrịa nke na-mara dị ka osteoporosis (gụnyere postmenopausal osteoporosis nwanyi). Alendronate sodium ọma na-eji maka ọgwụgwọ nke elu plasma calcium ozo na ọrịa na ịza aza Filiks.

contraindications

Official ọgwụ "Osterepar" ntuziaka nwere a zuru ndepụta nke contraindications ọgwụ bu n'obi. Ya mere, "Osterepar" na-contraindicated maka ojiji na ụmụ, dị ka ikpeazụ ngwaahịa na arụmọrụ nke nchekwa nke ya iji na-adịghị anya.

Alendronate sodium na-adịghị gosiri n'oge e guzobere lactation, udia na-ebu afọ ime. Ọzọkwa, ọgwụ na-contraindicated na belata plasma etoju nke calcium erughi rickets na vitamin D. akpachapụ Anya agwọ ọrịa ga-eji na ọrịa na ya erughị eru gbasara akụrụ excretory ọrụ.

mmetụta

Tupu iwebata n'ime adakarị omume nke alendronate sodium bụ abụọ-ìsì, placebo-achịkwa ọmụmụ. Dị ka ihe ndị a ọmụmụ ugboro nke n'akụkụ Jeremaya mere n'etiti ndị na-ewere alendronate sodium, bụ ubé ala karịa ugboro nke oghom Jeremaya mere na ọrịa emeso ya na placebo.

N'etiti oghom Jeremaya mere site ọgwụ "Osterepar" ọrịa kwuru ọrịa nke eriri afọ tract (dyspepsia, abdominal mgbu, ọrịa nke oche na a ọchịchọ afọ ntachi) na Central ụjọ usoro (isi ọwụwa). E nwere ndị ọzọ mmetụta metụtara na ojiji nke "Osterepar" ọgwụ ọjọọ. Ntuziaka maka ojiji na-egosi nnọọ obere nfụkasị Jeremaya dị ka ihe ọkụ ọkụ ma ọ bụ itching.

adọ aka ná ntị

Inweta "Osterepar" mbadamba kwesịrị ịna-aṅụ nkịtị mmiri ọṅụṅụ dị ka ndị ọzọ na-aṅụ (ịnweta mmiri, mmiri ara ehi, ihe ọṅụṅụ mkpụrụ osisi) nwere ike imetụta bioavailability na-akwụsịlata ya absorption. Ebe ọ bụ na sodium alendronate nwere ike iwe na elu akụkụ ụfọdụ nke eriri afọ tract, mbadamba kwesịrị iwere na ọtụtụ mmiri (full cup). Na kehoraizin ọnọdụ, e nwere ihe ize ndụ nke na-emepe emepe esophageal ọnya na n'ikuku "Osterepar" ọgwụ ọjọọ. Ntuziaka maka ojiji na-ede na ọ dịghị mkpa maka dịkarịa ala, ọkara otu awa iji gaa bed mgbe na-ewere ọgwụ ọjọọ, nakwa dị ka na-ewere ọgwụ tupu bed.

Anya ọgwụ kenyere ọrịa na-enwe eze na-ọrịa, gụnyere akpụ Jenesis. Mgbe na-ekenye "Osterepara" na-atụ aro na-ata a full eze nnyocha na-ebu a zuru reorganization nke onu oghere. eze usoro kwesịrị ẹse n'oge n'ikuku.

Mgbe ogologo oge ọgwụ (ihe karịrị otu afọ na ọkara) ọgwụ ọjọọ si na ìgwè nke bisphosphonates, nwere ike ime ka hip fractures na proximal akụkụ. Na ihe omume nke a mgbaji ọkpụkpụ nke onye ọrịa na-atụ aro iji zipu maka nnyocha nke abụọ nke femur maka mbenata likelihood nke re-mgbaji ọkpụkpụ. Ke adianade do, "Oseoreparom" ọgwụ na-kwụsịrị ruo mgbe ihe ize ndụ-uru ntule nke ọgwụgwọ.

Special ntị kwesịrị nhọpụta nke "Osterepara" na ọrịa na-ewere glucocorticoids. Ndị a ọgwụ ọjọọ nwere ike na mbenata absorption na, karị, na calcium na vitamin D oriri ke idem. Na ndị ọrịa a, hypocalcemia nwere ike iyi asymptomatic ma na-egosipụta oké n'iru a mkpụrụ ndụ ihe nketa pụrụ ịrịa. Iji gbochie nke a sikwuoro na-adọ nchoputa hypocalcemia atụ aro huu ezigbo calcium na vitamin D. n'ikuku

The ọgwụ na-adịghị kenyere ka ọrịa na a obere na genetically mere ọrịa metụtara na lactose ekweghị ibe nọrọ.

The ọgwụ nwere dịghị utịp ke mmeghachi omume ọnụego na ikike iji rụọ ọrụ ígwè. Otú ọ dị, anyị ga-echeta na e nwere nsogbu na oghom Jeremaya mere mgbe na-ewere "Osterepara" pụrụ imetụta ndị a Filiks.

Drug interactions

"Osterepar" na-atụ aro maka nkwonkwo ojiji na-aspirin, ebe ọ bụ na aspirin enwekwu mmetụta nke alendronate sodium (akpan akpan ya utịp ke nsia tract). Otú ọ dị, "Osterepar" ọma nakweere ọrịa na-anata ndị ọzọ ọgwụ na-abụghị steroidal mgbochi mkpali ọgwụ ọjọọ. N'agbanyeghị na a na eziokwu, onye kwesịrị izere jikọtara ihe ndị a ọgwụ ọjọọ eme ihe dị ka mgbochi mkpali ọgwụ ọjọọ ndị so ná ndị ha nwere ike ime ka ịrịba mmetụta.

Nzube nke alendronic acid inyom na-anata estrogens na n'ihu Nchikota na a progesterone, mee ka a ọzọ akpọ abawanye na ọkpụkpụ uka na a ịrịba ọnụ na na ọkwa nke ọkpụkpụ resorption.

Thiazide mamịrị ọgwụ na Nchikota na n'usoro designation alendronic acid na-eduga ná a ọnụ nke calcium na ọnwụ ma na-ebelata mmetụta nke "Osterepara".

Nsi na ọgwụ ovadozu

Ọ bụrụ na nsí alendronate hụrụ si a bowel aghara, na-egosipụta na ụdị vomiting, nrekasi obi, esophagitis na mmerụ ahụ na bowel lumen. Na akụkụ nke skeletal usoro na ọbara usoro nwere ike ime ka hypocalcemia na hypophosphatemia.

Ọgwụgwọ nsi na ovadozu na-eduzi na ọgwụ nkịtị na nsia lumen na ya inactivation. Ị nwere ike iji mmiri ara ehi, antacids, calcium dabeere binders. Self-eji vomiting ekwesịghị ịbụ, n'ihi na ọgwụ nwere ike ime ka iyatesịt na Burns nke na nkọlọ. N'ihi na gastric lavage bụ mkpa na-eji a nyocha. Symptomatic ọgwụ, na iji na kwụsie ike na calcium larịị ke ọbara plasma.

Nyocha nke dọkịta na ndị ọrịa

On nkwadebe "Osterepar" Ibọrọ iche iche, ma na-akasị mma. Site ọrịa na-ewere ọgwụ, iwe kpatara ihe irritant mmetụta nke ọgwụ na mucosa nke nsia tract. Si ele ihe anya nke dọkịta, ọgwụ ọjọọ, "Osterepar" analogs nke ọgwụ nwere alendronate sodium ndị dị irè na -emeso osteoporosis nke dị iche iche Jenesis nakwa dị ka ọrịa na nke nweekwa usoro.

Analogs agwọ ọrịa

Na-emepụta ọgwụ ahịa na-anọchi anya a zuru ezu ọnụ ọgụgụ nke analogs nke ọgwụ nwere alendronate sodium ka onye nọ n'ọrụ mgwa. "Alendronate" "Alendronic acid", "Alental", "Strongos" Tevanat ". All ndị a, na ọtụtụ ndị ọzọ ọgwụ ọjọọ eme ihe - analogues nke ọgwụ "Osterepar".

Ntuziaka maka ojiji nke analogues nke ọgwụ adịghị egosi Otú ọ dị, ọ bụrụ na e a akụkụ nke alendronic acid - ọgwụ ike ga-eji pụrụ iche maka ọgwụgwọ nke osteoporosis.

ọgwụgwụ

Osteoporosis - eji nwayọọ ọrịa, na ya ọgwụgwọ bụ mgbagwoju ogologo. Olee otú ikwu okwu banyere ọgwụ ọjọọ, "Osterepar 'ntuziaka maka ojiji, emeputa, ọrịa na dọkịta, ojiji nke n'aka a mmetụta bara uru na skeletal usoro, normalizing na calcium na site metabolism na usen ọkpụkpụ resorption.

Otú ọ dị, n'oge na ochichi nke ọgwụ, nke kacha mmetụta, ị ga-eso a ole na ole dị mfe iwu na-akọwara ntuziaka maka ojiji, na mgbe nile nkwurịta okwu na dọkịta gị izere ekwesighi mmetụta nke ọgwụ ahụ. N'oge ọgwụgwọ, adịghị eleghara oru nke ọkachamara, dị ka ha bụ isi ihe na-aga nke ọma ọgwụgwọ na a na-awụ ọsọ mgbake.