Ursodeoxycholic acid: ntuziaka maka ojiji, analogs, reviews

Nso nso a, maka ọgwụgwọ nke dị iche iche na imeju ọnya na-esiwanye eji ursodeoxycholic acid. Ntuziaka maka ojiji nke chemical compound egosi ya irè na ọtụtụ oké njọ nke ọrịa. Gịnị bụ nke a stof? Gịnị bụ ursodeoxycholic acid? Na ihe ngwaahịa na ọ bụ ugbu a?

nkọwa

Ursodeoxycholic acid, na ojiji nke a na-dabere na ya si na Njirimara, bụ a-acha ọcha-acha odo odo crystalline ntụ ntụ. Ọ nwere a ilu uto. Nke a na umi bụ na a na-ejikarị arụ ọrụ mmadụ na-emepụta obere obere. Ya kpọmkwem ike ndọda bụ banyere 5% site na ibu nke ngụkọta bile asịd. Ọ bụ hydrophilic na ọ dịghị ihe cytotoxicity. Nke a chemical compound bụ soluble na mmanya na ice acetic acid, ubé soluble na chloroform na fọrọ nke nta unyi anaghị agbasa na mmiri. Ursodeoxycholic acid na-adịghị dị na ngwaahịa. Ọ hụrụ na-elu ilu eriri afo nke aja aja bear.

Ursodeoxycholic acid (UDCA) bụ epimer nke chenodeoxycholic acid. Ná mmalite ya mee maka ọgwụgwọ nke reflux mgbu na gbawara gallstones. N'ime oge ahụ, ọ malitere ga-eji, na ọtụtụ ọrịa ndị ọzọ. UDKH ihe kasị ala nke bile asịd.

Mmetụta nke ursodeoxycholic acid

Iji ụbọchị, ojiji UDKH bụ a ọkọlọtọ ọgwụ dị iche iche dị cholestatic ọrịa imeju na-autoimmune akụrụngwa. The usoro nke ihe nke a gị n'ụlọnga bụ nụ mkpụrụ ndụ nke ahụ. Ya ụmụ irighiri nwere ike webata membranes nke imeju mkpụrụ ndụ - hepatocytes. N'ihi nke a ha na-enwe ike eme ka ha ọzọ eguzogide corrosive ihe. Nke a hepatoprotective gị n'ụlọnga nwere a choleretic mmetụta. UDKH belata cholesterol njikọ na imeju na-na-egbochi ya absorption na eriri afọ. A ọgwụ lowers na-akpọlite lithogenicity bile acid ọdịnaya nime ya. Ọ enhances ọrụ nke lipase, pancreatic na gastric secretion. Ursodeoxycholic acid nwere a hypoglycemic mmetụta na-akpali e guzobere na nkewa nke bile, ọ na-ebelata cholesterol.

A ọgwụ hụrụ ele mmadụ anya n'ihu ma ọ bụ zuru ezu cleavage nke cholesterol nkume. Ọ bụ ya mere ọ na-eji ọzọ mgbe. Ijikọ na cholesterol, ọ enwekwu solubility nke ya kristal, nke na-eme deleteriously on gallstones. UDKH nwere immunomodulating edinam nke bụ dịkwuo lymphocyte ọrụ, ebelata okwu dị iche iche abụkwara na membranes nke hepatocytes. Ọ na-emetụta ọnụ ọgụgụ nke T-lymphocytes, ebelata ọnụ ọgụgụ nke eosinophils.

UDKH ebelata ịta nke cholesterol na bile site ya dispersion na Transition nke umi na mmiri mmiri crystal adọ. Ọ na-emetụta ndị enterohepatic nrugharị bile salts. Dị ka a N'ihi nke a ebelata reabsorption ke gootu nke endogenous hydrophobic na-egbu egbu ogige. A ọgwụ nwere a kpọmkwem hepatoprotective na choleretic mmetụta. Ursodeoxycholic acid, nke Nyocha nke ọkachamara na hepatology gosi ya irè, bụ ike nke na mbenata imeju fibrosis ya ọdụdụ mbelata.

ngwa

Ursodeoxycholic acid, nke ngwa a rụrụ n'okpuru nlekọta nke ịga dibịa na-kenyere na ndị dị otú ahụ enweghị nchịkwa ọnọdụ:

• ọnụnọ nke cholesterol nkume metụtara nanị akụkụ ụfọdụ na gallbladder ma ọ bụ nkịtị duct;

• enweghị ike na-emeso endoscopically ma ọ bụ surgically;

•-adịghị ala ala, gbara gharịị, na nnukwu autoimmune ịba ọcha n'anya ;

• ọnụnọ nke cholesterol nkume mgbe n'ibu na extracorporeal lithotripsy;

• na-egbu egbu (ọgwụ, na mmanya), imeju mmebi;

• ọrịa sclerosing cholangitis;

• isi biliary imeju, na-enweghị ihe ịrịba ama nke decompensation;

• atresia, biliary tract;

• cystic fibrosis;

•-adịghị ala ala-arụsi ọrụ ike ịba ọcha n'anya;

• cholestasis n'oge parenteral oriri na-edozi;

• biliary dyskinesia;

• biliary dyspeptic syndrome na biliary dyskinesia na holetsistopatii;

•-adịghị ala ala opistorhoze;

• congenital biliary atresia;

• biliary reflux esophagitis na reflux mgbu.

Ursodeoxycholic acid (UDKH) eji maka mgbochi nke imeju mmebi rata site ochichi nke cytostatics na mmiri ọgwụ gbochie afọ. Ọ na-kenyere ka ọrịa ndị ọzọ kpatara ọnọdụ na-achọghị nke bile. UDKH kenyere maka adjuvant ọgwụ na imeju transplantation ma ọ bụ ndị ọzọ ngwa.

contraindications

Ursodeoxycholic acid, nke reviews na ọtụtụ akụkụ nke oma, nwere oké njọ contraindications. Ndị a gụnyere:

• mkpali oria nke ńsí eriri afo, eriri afọ na opi mgbailu na nnukwu-adọ;

• rentgenopolozhitelnye gallstones na elu calcium ọdịnaya;

• mgbochi nke biliary tract;

• hypersensitivity;

• imeju n'oge decompensation;

• Crohn ọrịa;

• akpọ ụfọdụ n'ime ịrụ ọrụ nke pancreas, imeju na-na akụrụ.

na-agaghị emeli nke iji

Ursodeoxycholic acid, ntuziaka maka ojiji nke egosi n'ụzọ doro anya na-anọghị nke na nlezianya na-agaghị emeli na ya ngwa, na-adịghị kenyere ụmụ ọhụrụ ruo afọ 3 na Capsule ụdị. Ka ha were n'imeso a slurry gụnyere a ọgwụ umi. Ruo ugbu a, ndị ọkachamara na-adịghị na e duziri kwesịrị ekwesị ọmụmụ iji na-ekpebi ihe nke a umi cholelitolitic dabere n'afọ ole nwa. N'otu oge ahụ, ọmụmụ ekenịmde ke ọnụnọ nke ụmụ na biliary atresia na ụfọdụ imeju ọrịa na-adịghị gosiri kpọmkwem ụmụaka nsogbu.

Preparations nwere ursodeoxycholic acid, nyere ụmụ nwaanyị dị ime na mgbe chọrọ mmetụta nke ọgwụ na a gị n'ụlọnga bụ ukwuu karịa nwere ihe ize ndụ ka nwa e bu n'afọ. Anyị ekwesịghị ichefu na zuru na nkà mmụta sayensị na-amụ chemical nchekwa n'ihi na nke a udi nke ọrịa na-dịghị onye nọrọ. Ebe ọ bụ na a na-amaghị ma UDKH penetrates n'ime mmiri ara, dị mkpa ịkpachapụ anya ná nhọpụta nke ọgwụ na-enye nwa ara nwanyi.

mmetụta

Ursodeoxycholic acid, ntuziaka maka ojiji nke na-egosi bụghị nanị na-agaghị emeli na ya ngwa, kamakwa ọ pụrụ ịkpata, pụrụ iduga enweghị nchịkwa phenomena dị ka:

• afọ ntachi, afọ ọsịsa;

• ọgbụgbọ;

• ụba transaminases;

• mgbu na nri elu quadrant na epigastric region;

• anabata akpụkpọ Jeremaya mere (itching, ọkụ ọkụ);

• calcining nkume.

Ọgwụgwọ nke isi biliary imeju nke a nkwadebe mgbe ụfọdụ na-akpata na-enwe ndidi nwere decompensation anaghị adịte, n'anya mgbe ndọrọ ego na-anata a ọgwụ.

precautionary jikoro

Iji ọma litholysis cholesterol nkume iji UDKH mkpa iji gaa na akaụntụ ndị na-esonụ ọnọdụ:

• ha size bụghị ihe karịrị 2 cm;

• ha adịghị enye ndo na radiograph;

• gallbladder na-arụ ọrụ na-ejikarị;

• ducts ịnọgide na-enwe patency;

• a afụ jupụtara na nkume na-erughị ọkara;

• nkịtị bile duct anaghị nwere nkume.

Olee ihe ndị ọzọ mgbochi mbanye bụ ursodeoxycholic acid? Ntuziaka ka a ọgwụ na preparations na-egosi na ogologo oge ọgwụgwọ, nke bụ ihe karịrị 1 ọnwa, ga-ahụ mgbe nile (1 bụla ụbọchị 30) kụziere nlekota nke hepatic transaminases, phosphatase, bilirubin, gamma-glutamyl transferase ọbara. Ịmụrụ ndị dị otú ahụ chọpụtara dị mkpa karịsịa na mbụ 3 ọnwa nke ọgwụ na UDKH. Irè nke ọgwụgwọ na-egosi na X-ray ọ bụla ọnwa isii na ultrasound bile. N'ihi mgbochi nke nlọghachite nke ọdịdọ-anọgide na-cholelithiasis ọgwụgwọ na mgbe zuru ezu na mgbasa nke nkume. Ọ nwere ike na-ewe ọtụtụ ọnwa.

N'oge ọgwụgwọ UDKH inyom nke ịmụ nwa afọ na-atụ aro iji pụrụ ịdabere na ụzọ nke nchedo ime. O nwere ike ịbụ na-abụghị mmiri ọgwụ ọjọọ ma ọ bụ gbochie afọ nwere obere estrogen.

Hapụ ụdị na onunu ogwu

Ursodeoxycholic acid, site nke ntụziaka ntuziaka na-enye nkọwa zuru ezu nke ya n'ikuku circuitry, na-arụpụtara ndị dị otú ahụ usoro onunu ogwu iche:

• capsules na mbadamba nke 150 na 250 mg;

• nkwusioru maka ụmụaka.

Ọnụọgụ ọgwụ UDCA nditịm setịpụrụ n'otu n'otu. Ọ na-adabere ogo nke ọnọdụ mmadụ na-aru-ya ibu ibu. N'ọnọdụ ka ukwuu, ọ na-kenyere 10-20 mg / n'arọ kwa ụbọchị. Nke a dose-e na otu oge, ná mgbede. Na oge nke ọgwụ na-adabere na-egosi. A ọgwụ na-etinye obi gị dum na obere eriri afọ, na mgbe 3 awa plasma na-kwuru n'ihi na ya kasị elu ịta. Ịnọgide n'ikuku ọgwụgwọ nwere ursodeoxycholic acid, na-eme ka ọ bụ isi bile acid na ahụ mmadụ. Nke a ihe onwunwe e doro a dịgasị iche iche nke mgbanwe na ikpeazụ N'ihi bụ mmepụta dị ka metabolites na na nsị na mmamịrị.

Duration nke ọgwụ kpebisiri ike site ịga dibịa. Ọ nwere ike ịdị iche iche dabere na ụdị ọrịa. Na ụfọdụ oké ikpe, n'ikuku UDKH ọgwụ ọjọọ ewe ọtụtụ afọ.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

Na a na nkwonkwo n'ikuku na UDKH "Cyclosporine" na-ejighị n'aka na-abawanye na absorption nke ikpeazụ. Na plasma dị ịrịba ama enwekwu ịta nke ọgwụ preparations. Na obere okwu n'ikuku UDKH n'out oge na nkwadebe "Ciprofloxacin" ikpeazụ ịta mbelata.

Ursodeoxycholic acid (analogues)

Ursodeoxycholic acid (capsules, mbadamba) arụpụtara n'okpuru aha dị iche iche. Ndị dị otú ahụ mmadụ dị iche excipients abanye ha mejupụtara. N'ihi ya, ahịa nwere ike izute ndị a ọgwụ ọjọọ eme ihe na ursodeoxycholic acid:

• ọgwụ "Ursosan" kenyere ọgwụ asị ibe ọrịa imeju, cholelithiasis, na biliary reflux mgbu na reflux esophagitis, bụ isi imeju, ọgwụ ọjọọ na-egbu egbu imeju mmebi, cholecystectomy, mmanya ọrịa, ọrịa sclerosing cholangitis, Biliary atresia, nonalcoholic steatohepatitis. Ursodeoxycholic acid ( "Ursosan") na-eji maka mgbochi nke imeju ọnya.

• Mbadamba "Ukrliv" na-na hepatic impairment, ala ala ịba ọcha n'anya, cholelithiasis.

• ọgwụ "Ursofalk" nominated n'ihi na dị iche iche ọrịa na nke gallbladder na imeju na, Bilie cholestasis, a ọnụ nke ụfọdụ imeju ọrụ, elu cholesterol etoju. Ndị a gụnyere ndị isi biliary imeju na ọrịa sclerosing cholangitis, reflux mgbu na reflux esophagitis, ịba ọcha n'anya nke dị iche iche etiology, cholesterol nkume, cystic fibrosis, multiple ọnya nke imeju, bile stasis. Nke a nkwadebe na-eji dị ka a prophylactic megide imeju mmerụ anara nke nwere ike ọgwụ ọjọọ.

• Mbadamba "Ursodeks" na-na biliary imeju enweghị decompensation mgbaàmà na reflux mgbu. Ha na-eji na igbari obere cholesterol nkume kwesịrị ịrụ ọrụ nke ńsí eriri afo.

• ọgwụ "Ursodez" mee gbarie cholesterol nkume, ọgwụgwọ nke reflux mgbu, n'ihi na symptomatic ọgwụ ndị bụ isi imeju nke imeju na-enweghị ihe ịrịba ama nke decompensation.

• ọgwụ "Ursolizin" nominated n'ihi na dissolving cholesterol nkume, na symptomatic ọgwụgwọ nke biliary imeju, gallbladder cholesterosis na reflux mgbu. The ọgwụ na-eji na mgbagwoju ọgwụ ndị ọrịa na-adịghị ala ala ịba ọcha n'anya na imeju.

• ọgwụ "Choludexan" na-eji maka ọgwụgwọ nke na-adịghị mgbagwoju cholelithiasis, ala ala ifịk ịba ọcha n'anya, na-aba na-egbu egbu imeju ọnya, nonalcoholic steatohepatitis, bụ isi biliary imeju, bụ isi ọrịa sclerosing cholangitis, cystic fibrosis, biliary dyskinesia, reflux mgbu na reflux esophagitis.

• ọgwụ "Urdoksa" na-kenyere na isi biliary imeju, na-enweghị ihe ịrịba ama nke decompensation, reflux mgbu. The ọgwụ ọma na dissolves ndị obere na-ajụ cholesterol nkume, mgbe nọgide na-enwe ahụ nkịtị ọrụ nke ńsí eriri afo.

• ọgwụ "cursor C", e kenyere na-adịghị mgbagwoju cholelithiasis, bụ isi imeju, nnukwu na-adịghị ala ala ịba ọcha n'anya, ọrịa sclerosing cholangitis, atresia intrahepatic tract, reflux mgbu na reflux esophagitis, cholestasis, n'oge parenteral oriri na-edozi, biliary dyskinesia, ọrịa imeju, na cystic fibrosis, abụba gepatoze, dyspeptic ọrịamkpokọta. The nkwadebe na-eji maka mgbochi nke imeju mmebi na ojiji nke mmiri ọgwụ gbochie afọ na cytostatics, nkume guzobere na ibu oké ibu.

Ursodeoxycholic acid, analogs nke ihe a na-iwere na kenyere onye dọkịta.