Calcium akụ ọkpọ - sara mbara-ụdịdị dị iche iche ọgwụ ọjọọ eme ihe

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Na ndụ nke organism mezie calcium ion egwu a kama mkpa. Nke bụ eziokwu na ọ bụ calcium, na-abami n'ime mkpụrụ ndụ ike rụọ ọrụ niile zhiznenovazhnye intracellular Filiks ihe organism, e.g., na ntughari nke ATP n'ime Ogige ma ọ bụ protein phosphorylation Filiks.

Regulation nke calcium ion ke idem

Calcium penetrates mkpụrụ ndụ site na pụrụ iche ọwa, nke bụ nnukwu protein ụmụ irighiri nke ijupụta site multilayer akpụkpọ ahụ nke mkpụrụ ndụ. Ndị a "ọwa", gụnyere ndị ọzọ, nwere kpọmkwem anabata, nke a rụrụ na njirimara nke calcium ion, na-enweghị awụgharị na ndị ọzọ ahụ.

Eruba n'ime calcium ion na organism na-usoro kpọmkwem endogenous ihe ndị pụrụ nwere dị ka neurogenic si na ibu endocrine ogbugbo dị ka acetylcholine ma ọ bụ serotonin.

Ọgwụ ndị na-egbochi ndị penetration nke calcium ion n'ime mkpụrụ ndụ

Studies nke ọgwụ ọjọọ na ike inhibit calcium ọwa nke Itie malitere na 60s na a ka na-aga. Ná mmalite nke a ọmụmụ ndị na-emeghe umi fenilakilamina nkwekọrịta, nke n'oge e chọrọ maka ka koronorasshiryayuschih preparations. Taa meghere nnọọ a ọnụ ọgụgụ buru ibu nke ndị dị otú bekee, nke na-achọkwa n'ime otu ìgwè, nke nwetara aha - calcium-akụ ọkpọ.

Jiri nke calcium na-akụ ọkpọ

Calcium akụ ọkpọ na-ugbu a n'ọtụtụ ebe eji dị iche iche ubi nke na nkà mmụta ọgwụ, nke a bụ n'ihi na eziokwu na ha nwere nnọọ a dịgasị iche iche nke edinam. N'ihi ya, n'ihi na ihe atụ, calcium-akụ ọkpọ ike imetụta myocardial contractility, atrioventricular conduction na imi ọnụ ọrụ.

A mmetụta yiri bụ aldosterone akụ ọkpọ na-egbochi ihe ruru ya conductivity aldosterone ihe nnabata, si otú amụba ego nke calcium na mkpụrụ ndụ.

Na ụdị ụfọdụ nke enweghị nchịkwa ọnọdụ, dị ka hypoxia ma ọ bụ ischemia, oké calcium ion ike welie intracellular Filiks, si otú amụba anụ ahụ oxygen ina, bụ nke pụrụ iduga iche iche-enweghị nchịkwa na mmetụta. Na nke a, na calcium-akụ ọkpọ nwere a ọgwụgwọ mmetụta, na ịmachi ihe nke calcium ion n'ime cell Filiks.

Calcium akụ ọkpọ maka ọgwụgwọ nke ọrịa metụtara na CAS

Ya bụ isi ojiji nke calcium ọwa blockers hụrụ taa na ọgwụgwọ nke ọrịa obi. Drugs pụrụ imetụta conductivity na excitability nke obi, nwere antianginal mmetụta, mma akwara ọbara na belata ọbara mgbali.

Ọgwụ ndị na-emetụta gbasara obi conduction na excitability taa ji dị ka antiarrhythmic ọgwụ ọjọọ, nke rụpụtara na nhọrọ nke a dị iche iche pharmacological otu (angianginalnye n'aka).

Akụ ọkpọ budata emetụta platelet aggregation, mbenata ha coalescence na Ọrụ disaggregation nke platelet. Ọgwụ ndị a na-eji iji belata ọbara viscosity ma dịkwuo ekwedo nke platelet. Dịkwuo ike nke ọbara anticoagulant nwere ike ide na vitamin K-akụ ọkpọ na akpaghasị ebighị nke prothrombin, igbochi guzobe fibrin egbochi mkpụkọ.

The ụdịdị dị iche iche nke edinam ọgwụ

The ụdịdị dị iche iche nke edinam nke calcium na-akụ ọkpọ bụ n'ezie iche iche, n'ihi na ha na-now bụghị nanị maka ịgwọ ndị isi ụdị ọrịa obi, ma n'ihi na ọgwụgwọ nke migraine, ụkwara ume ọkụ, ọrịa nke ụbụrụ mgbasa. Calcium akụ ọkpọ akpọ ọrụ dị mkpa na ọgwụgwọ nke ọrịa uche, na-eji na ọgwụgwọ nke Akwụkwụ na-adọ na dyskinesia na ọrịa na isi mgbaka.