Ọgwụ "Carboplatin": ntuziaka maka ojiji, analogs na reviews

Gịnị nwere ike dochie a ọgwụ dị ka "Carboplatin"? Analogs nke a ọgwụ ga-depụtara n'okpuru. Ọzọkwa na ihe ndị a n'isiokwu ga-ọkọnọ ọmụma banyere ezi ojiji nke si ego, ya na-egosi, mmetụta na contraindications.

Mejupụtara nkọwa, na udi nke agwọ ọrịa

Na ihe n'ụdị dị ọgwụ "Carboplatin"? The emeputa na-ekwu na ngwá ọrụ nwere ike zụrụ dị ka a na-acha ọcha lyophilized powder zubere maka nkwadebe nke ihe igba ogwu n'akwara ngwọta. Ya n'ọrụ mgwa ihe bụ carboplatin, na ndị ọzọ - mannitol.

Na ire ọgwụ uche "Carboplatin", ndị mejupụtara nke nke ayi togboro n'elu, abịa na karama na-enịm ke kaadiboodu nkwakọ.

pharmacological Njirimara

Gịnị bụ ọgwụ "Carboplatin"? Ntuziaka maka ojiji, nzaghachi akụkọ mgbagwoju inorganic compound nwere a arọ metal dị ka platinum.

Ndị ọkachamara na-atụ aro na usoro nke ihe nke a na ngwá ọrụ bụ ruru ya ike ikegide na DNA. N'ihi ya, kpụrụ vnutrispiralnye crosslinking igbanwe DNA Ọdịdị na inhibit ya njikọ. A mmetụta yiri emee n'agbanyeghị nke cell okirikiri na-adọ. Ọ ga-kwuru na hydration carboplatin, n'oge nke kpụrụ ifịk ụdị ọgwụ dị ukwuu iji nwayọọ karịa hydration nke cisplatin.

Kinetic afọ nke agwọ ọrịa

Olee otú ahụ mmadụ "Carboplatin" nkesa nke ọgwụ? Ntuziaka maka ojiji na-ekwu na mgbe a otu ochichi nke a gị n'ụlọnga n'ụdị infusion (IV) 60 nkeji, n'ime ọbara ịta nke free (i.e. amenable ultrafiltration) na ngụkọta platinum ebelata dị na abụọ na-adọ nlereanya nke mbụ iji pharmacokinetics.

Malite oge nke free platinum ndụ-nke ihe dị ka awa 2, na a ọnụ T1 / 2 - 3-6 awa. Ọ kwesịkwara kwuru na ngụkọta platinum e ji yiri mbụ ọkara ndụ, ma na njedebe-ya ogologo (banyere a ụbọchị).

Ugboro ugboro ochichi nke ọgwụ maka 4 ụbọchị a n'usoro n'ime ọbara ìgwè platinum chọpụtara. Mgbe otu ụbọchị mgbe ngwa nke ọgwụ banyere 85% nke nọ n'ọrụ mgwa na plasma na-agbụ na-edozi ọnọdụ.

Olee otú mkpochapu nke ọgwụ "Carboplatin"? Guide na-ekwu na nkwadebe na-ewepụtara tumadi akụrụ (ihe dị ka 30% nke dose wepụtara na unmodified ụdị).

Na ụmụ mmadụ CS 60 ml / min na n'elu banyere 65% na 70% nke na-eji metering mmepụta maka 11 na 23 awa, karị.

Ebe ọ bụ na mkpochapu "Carboplatin" na-ewe ebe fọrọ nke nta kpamkpam site glomerular filtration, naanị a obere ịta hụrụ na gbasara akụrụ tubules, nke na-akọwa na ala nephrotoxic nwere nke ọgwụ ka tụnyere cisplatin.

Anticancer ọgwụ "Carboplatin": àmà

Mgbe ụfọdụ, na-egosi na ojiji nke ọgwụ ọjọọ na-atụle? Dị ka ntụziaka, ọ bụ maka ọgwụgwọ nke na-esonụ etuto ahụ:

• ovarian cancer;
• cervical cancer;
• izizi cell etuto ahụ na ndị ikom na ndị inyom;
• osteogenic sarcoma;
• ọrịa cancer akpa ume;
• medulloblastoma;
• ozizi nke n'olu na isi.

Bans ojiji nke infusion ngwọta

Gịnị bụ contraindications ọgwụ nwere "carboplatin"? The ojiji nke a ọgwụ na-egbu ma ọ bụrụ:

• ara;
• oké njọ akụrụ pathologies (e.g., CC erughị 15 ml / min);
• ime;
• hypersensitivity ka carboplatin na ndị ọzọ ọgwụ, gụnyere a platinum;
• oké myelosuppression;
• ịrịba ọbara ọgbụgba, gụnyere ndị hụrụ na-adịbeghị anya gara aga;
• na nwata.

Ọzọkwa na-elezi anya a ọgwụ na-kenyere:

• a na-adịbeghị anya ịgba ọgwụ mgbochi ọrịa;
• ikpe impairment;
• gbasara akụrụ ọrịa;
• dara mbà n'obi ụmị ọkpụkpụ hematopoiesis, gụnyere ọnọdụ mgbe Radiotherapy na-anara ọgwụ;
• yiri iji ihe nephrotoxic ọgwụ (e.g., "Cisplatin");
• nnukwu nje nke malitere ịrịa, fungal na nje na malite.

Agwọ ọrịa "Carboplatin": ntuziaka maka ojiji

Olee otú emeso ihe anticancer ọgwụ ga-eji? Dị ka ndị ọkachamara, a agwọ ọrịa nwere ike etinyere dị ka a monotherapy, ma ọ bụ na Nchikota na ndị ọzọ n'aka na-enwe a mmetụta yiri (e.g., na Nchikota na "Paclitaxel" nkwadebe).

Dabere na ihe size na ebe ọrịa na-metụtara nanị akụkụ ụfọdụ akpụ, ndị dọkịta na-eji dị iche iche dosing "Carboplatin". Ọ ga-ndinọ intravenously dị ka ihe infusion n'elu 17-55 nkeji.

Olee otú m ga-eji ọgwụ "Carboplatin"? Eduzi ihe ndị na-esonụ Dosages nke ngwá ọrụ a:

• 100 mg / square mita ndidi ahụ kwa ụbọchị n'ihi na 5 ụbọchị;
• 300-400 mg / square mita nke onye ọrịa, ozugbo ọ bụla 4 izu.

Ọ ga-kwuru na n'agbata ochichi nke ọgwụ, na a nkezi nke 100 puku platelet / mm na 1.5 puku neutrophils / mm, kwesịrị dịkarịa ala 4 izu.

Tupu mgbe ngwa nke "carboplatin" ọzọ na-eduzi dị mmiri mmiri dị ka nke ọma dị ka ndị na-eme amanye diuresis a chọrọ.

Ọ bụrụ na onye ọrịa nwere oké hematological toxicity ma ọ bụ agafeghị oke nwere ike mkpa iji belata na onunu ogwu nke ọgwụ na 26%.

Mgbe gbasara akụrụ pathologies ukwu enwekwu ihe ize ndụ nke na-egbu egbu mmetụta nke ọgwụ, ya mere belata dose dabeere na CC larịị.

Ndị agadi, nakwa dị ka na mbụ ekenịmde myelosuppressive ọgwụ, na onunu ogwu ga-belata 22-25%.

Tupu iji, na infusion ngwọta ga-eduzi ya visual nnyocha iji chọpụta ma e nwere ọ bụla mere ihe ọjọọ na ya na agba ma ọ bụ adịghị.

Gịnị nwere ike mix powder ọgwụ "Carboplatin"? Ntuziaka maka ojiji nke na-azọrọ na-arụsi ọrụ ike iji ọgwụ a ga-diluted na glucose 5% ngwọta ma ọ bụ sodium chloride 9%. Na nke a na-hụrụ ịta kwesịrị 0.5-1 mg / ml.

The ọgwụ ngwọta ga-akwadebe tupu eji ya, ebe ọ bụ karịa adị ndụ nke a mbuaha nkwadebe bụ hà otu ụbọchị.

Omume by-agwa

Gịnị na-ezighị ezi omume na-eme ka ọgwụ ọjọọ, "Carboplatin"? Nyocha banyere ngwá ọrụ a na-ekwu na ọ pụrụ akpasu mmepe nke ndị na-esonụ oghom mmetụta:

• Eriri afọ akụkụ: n'ime 11-12 awa mgbe ojiji nke ọgwụ, onye ọrịa nwere ike ọgbụgbọ na vomiting. Belata ihe ize ndụ nke emetic Jeremaya mere iji aga n'ikuku antiemetics, nakwa dị ka intermittent ochichi nke a agwọ ọrịa maka 5 ụbọchị, ma ọ bụ a na-aga n'ihu igba ogwu n'akwara infusion maka ụbọchị. Ọzọkwa, ụfọdụ ndị ọrịa nwere oghom Jeremaya mere dị ka afọ ọsịsa, abdominal mgbu, mbufụt nke ọnụ na afọ ntachi.
• hematopoietic usoro: n'iji elu doses nke "carboplatin" nwere ike ebelata ọrụ nke ụmị ọkpụkpụ hematopoiesis. Ọzọkwa, a ọnụ ọgụgụ buru ibu nke ndị ọrịa pụta ìhè mgbaàmà nke anaemia, osisi ike nke nke na-adabere na onunu ogwu nke ọgwụ na-eji. Nọọkwa na-adakarị nsogbu ndị dị otú ahụ dị ka nje ọrịa, ahụ ọkụ, na-agba ọbara na ujo septic.
• NA elu na Central ụjọ usoro: n'ebe a elu likelihood nke na-emepe emepe elu neuropathies, nakwa dị ka Mbelata miri akaị na-aghọ nkọ, karịsịa na ndị mmadụ n'elu 65 afọ. Ke adianade do, o kwere omume ihe ịrịba ama nke CNS ọrịa ọrụ. Ruo ogologo oge ọgwụgwọ na ọgwụ nwere ike ime ka cumulative neurotoxicity.
• Akụkụ nke ọhụụ: na ojiji nke ego ọ bụ puru omume na-adịru nwa oge na-arịa ọrịa ma ọ bụ zuru ezu ọnwụ nke ọhụụ, na ọnwụ nke ikike ịhụ ìhè na ịmata ihe dị iche na agba. Sight mweghachi na mma-emekarị emee n'ime ọtụtụ izu mgbe discontinuation nke ọgwụ. Na ndị mmadụ na mkpọchị akụrụ ọrụ, bụ ndị nọ na-emeso ya na elu doses nke ọgwụ, kwuru, sị cortical ìsì.
• ikpe akụkụ: iwebata "Carboplatin" na ụfọdụ ọrịa na e ototoxicity, nke na-egosipụta onwe n'ụdị anụ ọnwụ na tinnitus.
• Allergies: fever, ọkụ ọkụ erythematous, pruritus, anaphylactic mmeghachi omume, urticaria, hypotension na bronchospasm. Ndị a nwere ike ime a nkeji ole na ole mgbe ọgwụ ochichi. Ọzọkwa, na obere okwu, ọrịa nwere ike na-enwe exfoliative dermatitis.
• Gbasara akụrụ usoro: iwebata "Carboplatin" ụfọdụ ọrịa na-enwe a nwa oge, dịkwa nwayọọ na-abawanye na ọbara ọgwụ ọjọọ na urea kasịnụ. Na nke a, nnukwu ọjọọ akụrụ bụ nnọọ obere. Ihe ize ndụ nke nephrotoxicity na ndabere nke eji nke a gị n'ụlọnga enwekwu na dose, nakwa dị ka ndị mmadụ na mbụ-emeso ya na cisplatin.
• Electrolyte itule: hypocalcemia, hypokalemia, hypomagnesemia, na hyponatremia.
• Imeju: a nwa oge na-abawanye na bilirubin kasịnụ, iwu na alkaline phosphatase n'ime ọbara pụrụ hụrụ. Ndị e mesoo na elu doses nke ọgwụ na autologous ụmị ọkpụkpụ transplantation, kwuru, ụfọdụ n'ime imeju.
• Mmeghachi omume ndị ọzọ: hemolytic-uremic syndrome, ike ọgwụgwụ, alopecia, congestive obi ọdịda, flu-dị ka ihe mgbaàmà, myalgia / arthralgia, nfụkasị Jeremaya, cerebrovascular ọrịa.

kpọmkwem ozi

Gịnị ọrịa kwesịrị ịma tupu eji ọgwụ "Carboplatin"? Ntuziaka, kwuru na-arụ ụka na infusion nke a ọgwụ naanị n'okpuru elekọta ya mgbe nile nke n'ụlọ ọgwụ nwere ike rụrụ, nke specializes na ọgwụgwọ nke cytotoxic mmadụ. Na nke a nhọrọ monitor kwere omume na-egbu egbu mmetụta, karịsịa mgbe elu doses nke ọgwụ.

Na N'ezie nke ọgwụ na a gị n'ụlọnga na-esote ọnwa atọ, ọrịa ga-eji pụrụ ịdabere na gbochie afọ.

N'ihi nkwadebe na ụdi ochichi nke ọgwụ ngwọta mkpa na-eji ọgwụ na-ezuru na adịghị nwere aluminum. Nke a bụ n'ihi na eziokwu na mgbe ọ na-interacts na ọgwụ ịkpali a kpụrụ na-akara Mbelata ke ọgwụ nrụpụta.

N'oge ọgwụgwọ, "Carboplatin" chọrọ oge akwara ozi ule, gụnyere ndị agadi na ndị mmadụ na mbụ-emeso ya na cisplatin.

Jiri nke a ọgwụ ike na-eduga mmepe nke ototoxic mmetụta, na Ya mere tupu ọgwụgwọ a ga-rụrụ audiometric ule.

N'okpuru nlekọta nke a clinically ịrịba imebi nke ndị ntị ike mkpa a dose ukpụhọde "Carboplatin" ma ọ bụ ya zuru ekpochapụ.

Ọ bụrụ na ngwaahịa na-abanye na akpụkpọ ma ọ bụ anya, itucha ozugbo na ọtụtụ mmiri. Ọ bụrụ na loro, n'aka na ọ dị mkpa ka i lebara maka ruru eru enyemaka.

yiri ọgwụ ọjọọ

Gịnị ọgwụ analogues nwere ike dochie anya "Carboplatin"? Ntuziaka maka ojiji anaghị nwere na nke a enweghị ihe ọmụma. Behind ya, ị ga-atụgharị ahụmahụ dọkịta. Dị ka a na-achị, ndị ọkachamara nwere ike ikwu na ihe ndị a analogues "Carboplatin" "Tsitoplatin", "Teksalok", "Displanor", "Oksiplat", "Oxaliplatin", "Platinol", "Cisplatin", "Eloxatin", "Platikad", "Plaksat "" Oksitan "," Oksatera "," Ekzorum ".

Nyocha nke anticancer ọgwụ

Ugbu a, ị maara ihe mere gị mkpa ndị dị otú ahụ a ọgwụ dị ka "Carboplatin" ( "Carboplatin Teva"). Ntuziaka maka ojiji nke a ọgwụ nwekwara e kọwara n'elu.

Evaluation nke ọrịa ndị toxicity na nrụpụta ọrụ nke ọgwụ "carboplatin" bụ controversial. Ụfọdụ ndị na-ekwu okwu banyere ihe ndị magburu onwe ya pụta ọgwụgwọ nke dị iche iche na cancer na ndị ọzọ nke ukwuu mgbe banyere nsí mmetụta nke ọgwụ ọjọọ dị iche iche ụmụ mmadụ na akụkụ na usoro, nakwa dị ka ndị ọzọ na-adịghị mma phenomena. Ọkachamara na-ekwu na e jikọtara ya na otu onye ọrịa ndidi nke nọ n'ọrụ ọgwụ umi na ya izugbe ọnọdụ. Na nke ọ bụla na-achọ ka cancer na-anara ọgwụ. Ọ bụrụ na ọgwụ "Carboplatin" onye ọrịa adịghị mma n'ihi ihe ụfọdụ ma ọ bụ ọzọ, mgbe ahụ, ọ na-anọchi na analogs. Nke a nnọchi antitumor ọgwụ enyere na 90% nke ikpe.