Fluticasone furoate: ntuziaka maka ojiji, analogs na reviews

Maka ọgwụgwọ nke mkpali Filiks aa na ahụ mmadụ na ma nnukwu na-adịghị ala ala ụdị, na-eji ọtụtụ ụdị nke ọgwụ ọjọọ. Ụfọdụ bụ ndị ndị so ná ndị e kere eke, ndị ọzọ na-emetụtachaghị homonụ.

On ọgwụ emetụta?

Ma ahiri nke ọgwụ ọjọọ eme ihe n'ụzọ dị irè na-emeso mbufụt, na-ezo flukatikazona furoate. Ọ triftorirovannoe compound a kwadebere synthetically. Site na ya agwa, na umi bụ ìgwè nke homonụ glucocorticoids. Drug akụrụngwa nwere a pụtara ike mgbochi mkpali mmetụta. Inwe a elu larịị nke affinitivnosti ka glucocorticoid anabata, ọ na-emetụta dị iche iche nke mkpụrụ ndụ, dị ka macrophages, lymphocytes, eosinophils, na ndị ọzọ. Ọzọkwa na isiokwu ahụ mmetụta nke mbufụt ogbugbo, ya bụ, chemokines na cytokines.

Olee otú ịbanye body?

The peculiarity nke a ọgwụ bụ na flukatikazona furoate ike-etinye obi gị dum site ahụ kpamkpam, dị ka a na-metabolized site imeju. Ya mere, umi e ji nwayọọ systemic ikpughe.

E nwere ndị na-esonụ iche nke ojiji nke ọgwụ:

• Intranasal ochichi. Na usoro a ọgwụgwọ bioavailability na-adabere na usoro onunu ogwu. Ọ bụrụ na ị na-esi n'aka 110 micrograms kwa ụbọchị, ya ọdịnaya na ọbara nke onye ọrịa na-adịghị n'ezie achọpụtara. Na ikpe nke na-ewere ọgwụ na a onunu ogwu nke 880 mg ugboro atọ kwa 24 awa, ya bioavailability bụ 0,5%;
• Ọ bụrụ na ị na-ahụ flukatikazona furoate inhalation, bụ ihe na-egosi nke ya bioavailability bụ 27,3%.

Ọzọkwa, ọgwụ nwere ike iwere ọnụ na intravenously.

A ọgwụ na-ejikọ na plasma-edozi na index nke 99% ma ọ bụ karịa. O mkpatụ na mkpụrụ ndụ ọbara uhie bụ negligible. Flukatikazona furoate nnọọ irè metabolized na imeju na-na enzymatically rapara na-adịghị njọ bekee zoro fluticasone. A ọgwụ dịtụ ngwa ngwa doo n'ọbara. Ọ bụrụ na ọgwụ a na-e jikwa ọnụ ma ọ bụ intravenously, ọ na-fọrọ nke nta kpamkpam wepụrụ si bile si eriri afọ na ihe enweghị akụkụ anyụpụ site na akụrụ ya.

na-agba akaebe

Fluticasone furoate, ntụziaka na nke bụchaghị esokwa ngwugwu nke nkà mmụta ọgwụ, na-egosi na ndị na-esonụ ọrịa:

• Year-gburugburu imi nsụchi agwa.
• Okpo ọrịa akpa ume, tinyere ala ala.
• Bronchial ụkwara ume ọkụ - dị ka mmezi nke jikọtara ọgwụgwọ.

Ọ bụrụ na ị nwere a doro anya ọrịamkpokọta, nke na-akọwara n'elu, na ngwaahịa dabere na nke a n'ọrụ mgwa nwere ike n'ụzọ dị irè isi nagide ha. Ma echefula na eziokwu dị mkpa banyere fluticasone furoate, nke bụ a hormone. Inye ndị dị otú ahụ a ọgwụ ike na dọkịta gị.

contraindications

Nke a na-emepụta ọgwụ na ngwaahịa nwere ọtụtụ contraindications na mmachibido iji. Ọ nwere ike ghara iwere na ndị na-esonụ mgbe:

• Hypersensitivity isi n'ọrụ mgwa.
• Children n'okpuru 18 afọ (na-enweghị a pụrụ iche dọkịta nkwanye).

The na ịmachi ihe maka inweta a ọgwụ nwere ike:

• Imeju dysfunction.
• Akpa ume ụkwara nta.
• Ọrịa na-adịghị gwọrọ kpamkpam, ma ọ bụ na-adịghị ala ala ụdị.

Banyere ọnọdụ nke ma ọ bụ mee ka ime na lactating inyom, fluticasone furoate, ntuziaka maka ojiji na-egosi na nke a ọmụma ezughị. A ọgwụ ga-eji naanị na ọnọdụ ụfọdụ ebe ihe ize ndụ na nke nwa ebu n'afọ ma ọ bụ nwa n'okpuru anya uru na nne.

mmetụta

The ntuziaka maka ojiji na-egosi na a pụtara ọtụtụ mmetụta nke a ọgwụ, nke na-adabere dịgasị iche iche nke ya ngwa. Intranasal ọgwụ ọjọọ, ha na-owụt dị ka ndị a:

• Abnormalities na akụkụ okuku ume na usoro: imi agba ọbara, ya anya na mucosal onya.
• Nfụkasị Jeremaya: ọkụ ọkụ na ozu, angioedema, anaphylaxis, urticaria.

Ọ bụrụ na fluticasone furoate, nke reviews ukwuu n'ime mma, na-eji kuru ọgwụ ọjọọ dị ka akụkụ nke jikọrọ ụdị, nwere ike ime ka ndị na-esonụ mmetụta:

• Ọrịa na-efe efe ọdịdị: influenza, oyi baa, bronchitis na ndị ọzọ yiri phenomena nke elu akụkụ okuku ume na tract. Ọ pụkwara ịmalite oropharyngeal candidiasis.
• Na-enwe nsogbu kwesịrị ịrụ ọrụ nke akụkụ okuku ume usoro, nke nwere ike owụt ke ụdị oropharyngeal mgbu, nasopharyngitis, Sinusitis, pharyngitis, ụkwara, dysphonia, na Sinusitis.
• Ọrịa nke connective na skeletal muscle anụ ahụ: fractures, arthralgia, ihe mgbu na azụ.
• Ị nwekwara ike na-enweta abdominal mgbu, oké isi ọwụwa, febrile phenomena, gafere, glaucoma, ebelata ọkpụkpụ njupụta, ndị dara mbà n'obi ịrụ ọrụ nke hypothalamus-pituitary-adrenal usoro, stunted ibu ke ụmụaka na-eto eto, cataract.

Esi etinye na ole?

Ịgba "Fluticasone furoate" nwere ike iwere intranasally ugboro n'ụbọchị. Ọzọkwa, ọgwụ ike ga-eji maka inhalation na Nchikota preparations. The onunu ogwu nke ọgwụ na-kenyere dabere na ọrịa afọ si 27,5 55 mcg. Iji nọgide na-enwe kenyere ịta nke nọ n'ọrụ umi 27,5 mg nke ọgwụ.

Manufacturers nke na-emepụta ọgwụ na ngwaahịa nwere dọrọ aka ná ntị na n'oge ọgwụgwọ na ọgwụ kwesịrị ịkpachara anya na mmejuputa eme na ike n'ihe ize ndụ. A na-agụnye omume nke na-achọ nlebara anya pụrụ iche na ngwa ngwa psychomotor Jeremaya mere, dị ka ụgbọala ma ọ bụ iji ígwè ọrụ.

ọgwụ interactions

Ọ bụrụ na concomitant ojiji nke fluticasone furoate ketoconazole atụ aro ịkpachara anya.

Ọzọkwa na-atụ aro maka imekotaotuugbo co-ochichi na "ritonavir". Nke a bụ n'ihi na ihe ize ndụ nke ike systemic fluticasone furoate.

ovadozu

The ọmụmụ ọgwụ umi puru data ovadozu ọrịa natara a dose nke karịa ndị na-atụ aro 24 ugboro, n'elu oge nke ihe karịrị 3 ụbọchị. N'ihi ya, e nweghị ihe àmà nke oghom systemic n'obiọma. Ma ọgwụ emepụta aka ná ntị na ihe nke glucocorticoids nwere ike mmepe. N'ọnọdụ dị otú ahụ e nwere mkpa na-edebe dibịa na ọgwụgwọ kwesịrị ekwesị dabere na ihe mgbaàmà.

preparations

E nwere ọtụtụ ọgwụ ọjọọ, isi nọ n'ọrụ umi nke bụ fluticasone furoate na-emepụta ọgwụ na ngwaahịa na ahịa: "Avamys", "Flutisan", "Nazofan", "Flutineks", "Seroflo", "Flohal" na "Fleksonaze". The kasị popolyarnym n'aka a akara bụ nke mbụ aha ya bụ n'ụlọnga. "Avamys" fluticasone furoate mejupụtara dị ka a Isi nọ n'ọrụ mgwa na dị na a ga-adaba adaba ịgba.

"Avamys"

Ngwá ọrụ a abụrụwo onwe ya na nke kacha mma n'akụkụ na ọgwụgwọ nke imi nsụchi. Na ọrịa a na e nwere ọ bụghị nanị na ọzịza nke mucous membranes nke imi na profuse orùrù-ya, kamakwa ocular ngosipụta n'ụdị tearing, itching, nācha ọbara-ọbara na-ata mmetụta "ájá". Nke a budata ebelata ihe mgbaàmà nke na àgwà nke ndụ kwa ụbọchị nwere adịghị mma mmetụta na ya arụmọrụ na-eduga ná ịrịba na emefu na ọgwụ. Ọkà mmụta sayensị achọpụtala na isi ihe mere maka anabata ngosipụta na-eje ozi excitation parasympathetic irighiri akwara na-ebu mkpali ogbugbo mucosa nke sinuses. Na niile mgbaàmà nke imi nsụchi si anagide ogwu "Avamys." Fluticasone furoate, gụnyere ya mejupụtara dị ka a Isi nọ n'ọrụ mgwa, eme na anabata analyzers ifịk saịtị na-egbochi ka a n'ihi nke mmeghachi omume nke mmadụ na allergens. N'ihi ya, ihe niile wetara na ọbụna na-agwụ ike mgbaàmà akwụsị na ọrịa àgwà nke ndụ na-budata mma. N'ihi na eziokwu na isi akụrụngwa nwere nnukwu mmekọrita na-anabata ya, ha njikọ aghọ nnọọ siri ike na inogide, nke na-enye na-adịgide adịgide mmetụta nke nkwadebe.

All contraindications na mmetụta nke ọgwụ na-na-metụtara eziokwu na-arụsi ọrụ ike umi pụtara "Avamys" - fluticasone furoate, ntụziaka maka nke na-e nyere n'elu. Ọ dọrọ aka ná ntị na-enweghị a ọgwụ a mmiri ọgwụ na-emepụta ọgwụ na ngwaahịa ike iwere.

Nchikota ngwaahịa

Takzhedlya ọgwụgwọ nke imi nsụchi, COPD na bronchial ụkwara ume ọkụ Tee jikọrọ preparations nwere fluticasone furoate, vilanterol na ụfọdụ inyeaka mmiri. The kasị ama na mba anyị bụ ka a na nkà mmụta ọgwụ "Relvar Ellippta". Nke a na-emepụta ọgwụ na ngwaahịa nwere ndị nọ n'ọrụ Efrata na-eso kasịnụ kwa dose:

• Micronized fluticasone furoate 100 mcg.
• Vilanterola trifenatat micronized 40 g.

Nke a na nkà mmụta ọgwụ na-abịa n'ụdị a metered powder maka inhalation. Ọ nwere a akpọ mgbochi mkpali na bronchodilator mmetụta. "Relvar Ellippta" na-ezo aka n'aka-enwe bronchodilator mmetụta, n'ihi na-arụsi ọrụ ike Efrata bụ mkpọtụ: a nhọrọ beta-2-agonists, na obodo glucocorticosteroid.

Egosi maka ọgwụgwọ na a ọgwụ na-agụnye:

• Bronchial ụkwara ume ọkụ, nke na-esi n'aka na-eji maka mmezi ọgwụ.
• Okpo ọrịa akpa ume na-adịghị ala ala ụdị (COPD). Na nke a, nchoputa nke ọgwụ ọgwụgwọ nwere ike budata belata exacerbations.

Kọwara ọgwụ ezubere nanị n'ihi na inhalation na-emepụta ugboro kwa ụbọchị na ụfọdụ oge (na mgbede ma ọ bụ ụtụtụ). Manufacturers nwere ike ikwu na mgbe usoro, itucha ọnụ na mmiri, ma ọ bụghị ilo ya.

Ọrịa na ụkwara ume ọkụ ga-ọgwụ, n'agbanyeghị nke ọnụnọ nke akpọ mgbaàmà nke ọrịa. Ọ bụrụ na n'oge kwusi n'etiti ọmụmụ ọgwụgwọ e nwere doro anya ngosipụta nke ọrịa, dọkịta na-emekarị mere onye na-beta _2-agonists obere edinam n'ụdị inhalations. Ọnụọgụ ọgwụ ahọrọ naanị ịga dibịa.

Ndị na-esonụ kasịnụ nke nọ n'ọrụ Efrata (vilanterola trifenatat na flukatizona furotat karị) nwere ike e kenyere maka ndị okenye na ụmụaka afọ 12 n'otu inhalation / 1 oge kwa ụbọchị:

• 22 g + 92 g;
• 22 .mu.g + 184 mg.

The mbụ dose na-kenyere a dọkịta ndị ọrịa ndị na-achọ ala-agafeghị oke kasịnụ nke nọ n'ọrụ bekee, dị ka nke ọma dị ka na ọgwụgwọ nke COPD okenye. Ọ ga-kwuru na, maka ọgwụgwọ nke ala ala akpa ume mgbochi na ụmụaka abụghị ọdabara. Otu onunu ogwu kenyere ndị na-imeju ọrịa n'elu nkezi.

The abụọ ụdị onunu ogwu kenyere ka ọrịa ndị na mkpa elu ịta nke nọ n'ọrụ bekee na ọgwụgwọ nke ụkwara ume ọkụ, mgbe kacha nta onunu ogwu anaghị akpa chọrọ mmetụta.

People n'elu 65 afọ, nakwa dị ka ndị nwere ọrịa akụrụ, na mgbazi nke ọgwụ na-adịghị mkpa.

Iji jiri a ọgwụ ke ngwugwu nwere a pụrụ iche inhaler nke nwere nuances nke ime ihe na mmezi. Ha na-kọwara n'ụzọ zuru ezu na ntụziaka n'ihu were na a chọrọ na-enyocha nchịkọta ọma.

Mmetụta nke ọgwụ pụrụ igosipụta na-esonụ iche:

• Ọtụtụ mgbe: elu akụkụ okuku ume na tract ọrịa, influenza, oropharyngeal candidiasis, oyi baa; migraine; arrythmia; nasopharyngitis, Sinusitis, rhinitis, hoarseness, ụkwara; abdominal mgbu; fractures, arthralgia, ihe mgbu na azụ; fever.
• Mgbe ụfọdụ okosobode: hypersensitivity, ọkụ ọkụ, angioedema, urticaria, anaphylaxis; nchegbu aghara; tremor; tachycardia.

Contraindications iji "Relvar Ellippta" bụ:

• -Asọ mmiri ara ehi protein ma ọ bụ ọ bụla akụrụngwa nke ọgwụ.
• Children ruo afọ 12 na afọ.

Na-elekọta ndị na-emepụta ọgwụ na ngwaahịa kwesịrị iwere na ọrịa na ọrịa obi osudistymi oké iche nke ụkwara nta nke ngụgụ na-adịghị ala ala na-efe efe.

Ụmụ nwaanyị dị ime na-kenyere ọgwụ naanị na mgbe mgbe ajụjụ banyere uru nke nne ya, ukwuu karịa ihe ize ndụ na nke nwa ebu n'afọ. Mgbe lactation ọgwụ ndinọ na njikọ na gbahapụrụ nke ara na n'ihe ize ndụ mkpochapu n'ihi na nwa.

The nkwonkwo ojiji nke ọgwụ ọjọọ, "Relvar Ellippta" na beta-blockers kwesịrị ẹse, ma e wezụga ebe dị oké mkpa. Ọ bụkwa uru na ịkpachara anya na Nchikota na "Ketoconazole" na "ritonavir".

analogs

Ọ bụrụ na ndị ọgwụgwọ nke imi nsụchi, COPD ma ọ bụ ụkwara ume ọkụ, i nwere ike ghara kenyere fluticasone furoate, analogs nke a ọgwụ nwere ike ịbụ na-anara nke ọzọ. Ahụ maka ahụike gị dabeere na onye e ji mara nke organism, nye iwu ka nri ọgwụ. N'etiti analogues nke a ọgwụ na-agụnye:

• "Asmaneks";
• "Aurobin";
• "Garazon";
• "Deksapos";
• "Karizon";
• "Abistan";
• "Beklat" na ụfọdụ ndị ọzọ ọgwụ na nke otu ọgwụ ìgwè na flukatizona furotatom.

Echefula na ndị ọgwụ ga-iwere na na ndenye ọgwụ, na nanị mgbe nlezianya na-amụ ntụziaka.