Ọgwụ nje "zyvox": ntuziaka maka ojiji, analogs

Na ọgwụgwọ nke nje ọrịa na dọkịta na-emekarị idepụta ọgwụ nje. Ndị a ọgwụ ọjọọ nwere a nnukwu ọnụ ọgụgụ iche. N'ezie, ụdị nile nke antiseptik na-emepụta ọgwụ na ngwaahịa gaghị ekwe omume ịmata, ma ụfọdụ ọgwụ megide nje na-efe efe na-akpali mmasị karịsịa.

Otu nke oge a na ọgwụ nje, nke bụ n'ime anyị ahịa nke ọgwụ - bụ "zyvox". Ntuziaka maka ojiji nke ọgwụ na-egosi na nke a antimicrobial gị n'ụlọnga nke bụghị. Ọ bụ nke a pụrụ iche otu - oxazolidinone. Isi nọ n'ọrụ mgwa ihe bụ linezolid. mmetụta nke ọgwụ ọjọọ, "zyvox", ntuziaka maka ojiji, analogs, mmetụta na contraindications: Next anyị ndị na-esonụ ozi ga-atụle.

Na ihe n'ụdị na-emepụta?

The ọgwụ dị na abụọ onunu ogwu iche:

• N'ụdị nsogbu dị iche iche, e sijiri ọcha ma ọ bụ acha na agba na na epe flavor. N'ime ndị a, a ngwọta pereoralnogo maka ojiji na-atụ anya na na 5ml nke okokụre nkwusioru ga-ebu 100 mg nke linezolid. The nsogbu dị iche iche e enịm ke a na-akpụ akpụ ike nke 150 ml. Ọzọkwa ke ngwugwu nwere a ji atụ ngaji na graduations (2.5 na 5 ml nke nkwusioru).
• N'ụdị mbadamba nwere 600 mg nke linezolid. Ngwugwu nwere a ọnya na 10 mbadamba n'ime.
• Infusion ngwọta nwere 2 mg linezolid / 1 ml, na nchịkọta nke 100, 200, 300 ml.

Gịnị bụ pharmacological mmetụta nke ọgwụ?

Active umi linezolid nwere ike banye n'ime n'ime nje cell, ka ha kee ha ribosomes na inhibit protein njikọ. Dị ka a N'ihi ya, ndị microorganisms na-gburu.

Against ọ bụla microorganisms enyere ọgwụ?

Drug "zyvox" ntụziaka ntuziaka nke esokwa onye ọ bụla ngwugwu na a na nkà mmụta ọgwụ na ihe n'ụzọ dị irè na-eme ndị na-esonụ microorganisms:

• Gram-mma aerobic bacteria: Enterococcus, Corynebacterium, Staphylococcus, streptococcus;
• Gram-adịghị mma aerobic bacteria nke genus Pasteurella;
• Gram-mma anaerobic bacteria: Clostridium na peptostreptokokki;
• Gram-adịghị mma anaerobic bacteria nke genera prevotella, bakteroides, chlamydia.

Iji linezolid moderately susceptible bacteria nke genera Moraxella, Legionella, Mycoplasma.

E nwekwara microorganisms nke igosipụta iguzogide linezolid, a akụkụ nke ọgwụ "zyvox". Ntuziaka maka ojiji na-egosi ndị na-esonụ na-eguzogide ọgwụ nje: Haemophilus bacteria, nakwa dị ka nnyefe enterobakteriatsea, nizera na pseudomonas.

Na ihe ọrịa ya na-egosi na nkà mmụta ọgwụ?

Ọgwụ nje "zyvox" e kenyere maka ndị na-esonụ ọrịa:

• Infectious na mkpali oria na-kpatara bacteria na-chebaara nyere ọgwụ.
• N'ọnọdụ nosocomial ma ọ bụ obodo-enwetara oyi baa.
• Na-efe efe ọnya nke anụ ahụ na adụ anụ ahụ nke ahụ mmadụ.
• Na ọnụnọ nke ọrịa, mmadụ nke bụ enterococci egosi iguzogide vancomycin.

Ọzọkwa, "zyvox" ọgwụ nje nwere ike ji mee ka a akụrụngwa nke a jikọrọ ụdị ọgwụ megide ibute ọrịa ịda ruru ka gram-adịghị mma bacteria.

pharmacokinetics

Linezolid e ji pụtara ngwa ngwa absorbability si digestive tract n'ime ọbara iyi, n'agbanyeghị nke ụdị ntọhapụ n'ụlọnga. Ugbua mgbe 2 awa mgbe ochichi nke ọgwụ, ya ịta na plasma esịmde a kacha. Linezolid e ji zuru bioavailability na ngwa ngwa bụ ya nkesa na akụkụ na anụ ahụ. N'agbanyeghị ihe na ịta nke ọgwụ nje na ọbara 31% ewee plasma-edozi.

Na ụmụ mmadụ, linezolid na-metabolized site ọxịdashọn abụọ ngwaahịa nke na-adịghị antimicrobial edinam. Ha na-anyụpụ site akụrụ (ihe dị ka 50%) na eriri afọ (ruo 6%). Ruo 35% na-abụghị metabolized ọgwụ nje anyụpụ na mmamịrị.

Gosiri na mụ pharmacokinetics, nke e ji ọgwụ "zyvox". Ntuziaka maka ojiji dabere na enweghị ọgwụ ule na ọrịa afọ. Ya mere, ndị agadi anaghị achọ mmegharị nke onunu ogwu nke na-emepụta ọgwụ na ngwaahịa.

onunu ogwu

The agwọ ọrịa "zyvox" nwere ike ikenye a dọkịta onye ọrịa maka onu ochichi ma ọ bụ n'ụdị igba ogwu n'akwara infusion ochichi. Ọzọkwa, onye ọrịa nwere ike a ga-agafere nke otu ụdị ọzọ ingestion-enweghị adịkwa irè nke ọgwụgwọ.

Ọgwụ onunu ogwu, oge nke N'ezie ga-akpọrọ ndị dibịa, na ọgwụgwọ nke ọnọdụ ndị a na-kpatara ndị na-esonụ ihe:

• ụdị bacteria e mere site na ọrịa;
• metụtara nanị akụkụ ụfọdụ ọrịa;
• ogo nke ọrịa;
• adakarị erite uru site ọgwụ.

Mgbe streptococcal oyi baa, na obodo-enwetara na ụlọ ọgwụ-ụdị na ndị okenye na ụmụaka afọ 12 ọgwụ 600 mg nke "zyvox" ọgwụ ọjọọ. Manual na-egosi na-ewere a dose ọgwụ ga-emejuputa atumatu 12 ọ bụla awa na N'ezie oge bụ 10-14 ụbọchị.

N'ihi na-efe efe nke anụ ma ọ bụ adụ anụ ahụ, mgbagwoju anya ma ọ bụ na-adịghị mgbagwoju mere site staphylococci, streptococci na enterococci eguzogide vancomycin, gụnyere ọrịa ụkwụ syndrome (na-enweghị osteomyelitis) kenyere dose "zyvox" 600 mg. Ntụziaka nwekwara-atụ aro na n'agbata na-ewere ọgwụ ga-awa 12. The ọgwụgwọ dịruru 10-14 ụbọchị, ma nwere ike ịdịru ruo 28 ụbọchị na ọgwụ ọgwụ.

Ọ bụrụ na onye ọrịa nwere gbasara akụrụ impairment, ndị dose ukpụhọde ọgwụ ọ chọrọ. Na hemodialysis usoro linezolid wepụrụ n'elu a oge 3 h. Na njikọ na nke a, ọgwụ kwesịrị iwere mgbe ihe omume na ịdị ọcha nke ọbara. Ọrịa ndị na-chọpụtara na mmebi imeju, na-anaghị achọ mmegharị nke usoro onunu ogwu.

Ọrịa tọrọ afọ 12 na-kenyere naanị n'ụdị ọgwụ infusion "zyvox". Ntụziaka maka iji na ụmụ ọhụrụ na ụmụ na-egosi na linezolid iwere na a onunu ogwu nke 10 mg / n'arọ ahu arọ nke nwa na a ugboro ole na 8 ọ bụla awa. The ọgwụgwọ bụ site 10 ruo 14 ụbọchị. Nke a onunu ogwu nke ọgwụ na Nde ọgwụ na obodo-enwetara na nosocomial oyi baa, adụ anụ ahụ na-efe efe, na anụ ahụ, dị ka nke ọma dị ka obibi enterococcal-efe efe.

Echebe n'ọbọ mere nke foil, a na-ewepụ ya ozugbo tupu infusion usoro. Ọ dị mkpa na-elele ngwugwu maka leaks site apịpụta ya maka 1 nkeji. Leaky nkwakọ unusable ruru ka ndị na-abụghị Vol. The infusion ngwọta na-ndinọ n'elu a oge nke 30-120 nkeji.

Atụmatụ nke ngwa

E nwere ụfọdụ atụmatụ n'ikuku "zyvox" ọgwụ ọjọọ. Manual na-egosi na ọ bụrụ na ọrịa na-kpatara gram-adịghị mma bacteria, ọ dị mkpa ijikọ ọzọ ọgwụ ọjọọ na-arụ ọrụ megide nke a nke microorganisms.

Mgbe anata linezolid ụfọdụ ọrịa nwere ike ime reversible myelosuppression. Dabere na oge nke ọgwụ e ji anaemia, leukopenia, thrombocytopenia ma ọ bụ pancytopenia. Dabere na ndị a data, nlekota ọbara adabere ga-rụrụ na ọrịa na ịkpata ọbara ọgbụgba. Ọzọkwa, ndị a jikoro ndị a kwesịrị ekwesị ma ọ bụrụ na onye ọrịa nwere a akụkọ ihe mere eme nke myelosuppression ma ọ bụ ọ na-ewe ọgwụ ọjọọ na belata etoju nke haemoglobin na platelet ma ọ bụ ọrụ ha. Assessment ọbara adabere dịkwa mkpa n'oge ruo ogologo oge ọgwụgwọ oge (14 ụbọchị).

Ụfọdụ ọrịa na-anata linezopida nwere ike so n'ihe ize ndụ nke afọ, pseudomembranous ọdịdị nke dị iche iche nke ike ndọda.

Afọ ọsịsa a na-efekarị ndị na-ewere ọgwụ nje ugboro ugboro. N'ókè nke a n'akụkụ mmetụta nwere ike ịdị iche iche site nwayọọ na oké. Mgbe na-ewere ọgwụ, "zyvox" Erere ma ọ bụ nkwusioru bụ, e nwere suppression nke nkịtị nsia microflora na overgrowth nke bacteria nke genus Clostridium. Na usoro nke ha ndụ a organism arụpụta nsí A na B iche iche, na ha ime ka afọ ọsịsa. Elu etoju nke a mmiri nwere ike igbu ndị ọrịa. All ọrịa ndị undergone ụdị afọ ọsịsa, mkpa ịkpachara anya nlekọta nke ndị ọrụ maka oge nke 2 ọnwa.

Mgbe ụfọdụ, a na-arịa ọrịa na ọgwụgwọ nke ọgwụ ọjọọ, "zyvox". Ntuziaka maka ojiji na ụmụaka na ndị okenye, na-egosi a ga-ekwe omume mgbanwe na agba nghọta, visual na-elekwasị anya, ubi ntụpọ, bịara ikiri. Na ndị a, ọrịa ga-ozugbo ịkpọ anya dọkịta. Ọ bụrụ na nke a na nkà mmụta ọgwụ na-e site ndidi ruo ogologo oge nke oge (karịa 3 ọnwa), mgbe ahụ, ọ bụ amanyere bụ iwu na-eme ka akara nke. Na omume na mmepe nke ihe dị ka elu neuropathy ma ọ bụ optic akwara, ajụjụ nke cessation nke usoro ọgwụ ma ọ bụrụ na uru site na ya bụ ihe na-erughị mebiri ike.

Ọzọkwa, e nwere ndị ikpe nke lactic acidosis mgbe na-ewere "zyvox". Ọ na-egosipụta onwe ya n'ụdị ọgbụgbọ, vomiting, acidosis ma ọ bụ na-ezighị ezi Mbelata carbonate anions. Nke a na onu ga-enyocha ekwu ọgwụ ọkachamara.

Ọ bụrụ na onye ọrịa nwere a mkpa na njikọ na "zyvox" na-ewere nhọrọ serotonin reuptake inhibitors, ọ kwesịrị iwere n'okpuru nlekọta nke ndị ọrụ iji chọpụta serotonin syndrome: a odida nke cognitive ọrụ, hyperreflexia, hyperpyrexia, na incoordination. Na ọnụnọ nke kọwara phenomena emepụta discontinuation nke otu ma ọ bụ abụọ ọgwụ ọjọọ. N'ihi ya, ọ achagharị nke nha nha Enamel, nke a na-ewepụ site ọkachamara ihicha.

E nwere ihe ọzọ caveat na-enweta "zyvox" ọgwụ ọjọọ. Ntuziaka maka ojiji (mbadamba ya ma ọ bụ nsogbu dị iche iche maka nkwusioru - dịghị mkpa) na-ekwu na: ọgwụgwọ na linezolid adịghị atụ aro na-akwọ ụgbọala ugbo ala, pụrụ iche ngwá management na arụmọrụ metụtara ize ndụ iji ndụ na ike.

Gịnị bụ mmetụta nke a ọgwụ?

Oghom Jeremaya mere nke nwere ike ime ka onye ọrịa mgbe na-ewere nke ọgwụ gị n'ụlọnga "zyvox 600 mg" nkewa site ịdị adị nke ugboro si nnọọ ugboro ugboro (10%) na nnọọ obere (0.01%).

A, n'akụkụ mmetụta na ọgwụgwọ nke ọgwụ ọjọọ, "zyvox" ntuziaka maka ojiji, a ngwọta ma ọ bụ mbadamba, onu na-akpọ nwayọọ ma ọ bụ agafeghị oke ntaramahụhụ. Special ọnụego nwere ndị na-esonụ àgwà:

• ọgbụgbọ;
• afọ ọsịsa;
• isi ọwụwa.

Na okenye ọrịa nwekwara ike na-enweta afọ ntachi, vomiting, ihe mgbu na afo, bloating, na vulvovaginal ọrịa nke onu oghere.

Site adịkarịghị aa mmetụta nke ọgwụ "zyvox" ntuziaka maka ojiji (maka ụmụaka n'elu 12 afọ na ndị okenye) kpọrọ mgbanwe na agba nke asụsụ nke na agba.

Dabere na laabu ọmụmụ, ọ nwere ike na-arụ ụka na n'oge ọgwụgwọ na a nje na-ahụrụ thrombocytopenia. Ọ bụghị otú ahụ mgbe nile hụrụ abawanye na ọbara etoju nke triglycerides, ndiiche ebighị nke imeju enzyme Alt, AST, alkaline phosphatase, LDH na lipase na amylase. na-abawanye na ịta nke ngụkọta bilirubin, creatine na prolactin nwekwara dere.

The ụjọ usoro nke ọrịa nwere ike na-eme ka ọgwụ na linezolid. Nke a na-egosi n'ụzọ dị vertigo na oké isi ọwụwa, nakwa dị ka cramps. Ụkọ ngosipụta nke ọgwụ mmetụta ọjọọ ndị ikpe nụrụ ụtọ rụrụ arụ.

Mgbanwe kwesịrị ịrụ ọrụ nke Central ụjọ usoro nwere ike ime ka "zyvox" (mbadamba). Guide na-egosi nnọọ nkịtị ehighị ụra nke ọma na-arịa ọrịa n'oge ọgwụgwọ na a na-emepụta ọgwụ nkwadebe.

The ọrụ nke genitourinary usoro ọgwụ eji "zyvox" nwere ike gosipụtara n'ụdị mmamiri candidiasis.

Ọtụtụ mgbe e na cutaneous ngosipụta nke linezolid ọgwụgwọ n'ụdị rashes.

Tinyere ihe ndị ọzọ mmetụta nwere ike na-akpọ febrile phenomena na opportunistic fungal ọrịa, nke pụtara infrequently.

Ọzọkwa, mgbe "zyvox" ọmụmụ ọgwụ na-hụrụ ikpe nke ọbara mgbali elu, itching na afọ mgbu.

Linezolid na ọgwụgwọ nke na nwa ọrịa noo 12 na afọ 17, mgbe mgbe hụrụ ndị na-esonụ ekwesighi mmetụta:

• afọ ọsịsa, vomiting, ọgbụgbọ, abdominal mgbu;
• vertigo, migraine;
• ọkụ ọkụ;
• na-efe efe nke elu karị, ụkwara, akpịrị;
• fever;
• mgbu nke siri ike na-akọwa orunótu.

Ndị na-esonụ phenomena nwere ike ime na-ji site a ala ugboro:

• eosinophilia;
• ntọt ke triglycerides, Alt, lipase na creatine;
• itching.

ọzọ mmetụta na-ahụrụ na-adakarị ọmụmụ, nke e ji "zyvox" (ngwọta, na mbadamba). Ndị a gụnyere:

• reversible myelosuppression;
• neuropathy nke optic akwara;
• anaphylaxis;
• agwa angioneurotic edema;
• lactic acidosis;
• elu neuropathy agwa;
• achagharị nke nha nha Enamel;
• akpata oyi;
• ike ọgwụgwụ;
• serotonin syndrome.

Dị ka "zyvox" ọ na-achọkwa na ndị ọzọ ọgwụ?

Mgbe ngalaba-ndinọ na cytochrome dịghị mgbanwe a hụrụ na nke ikpeazụ ọrụ.

Ọ bụrụ na n'otu oge ahụ-emeso ya na linezolid na monoamine oxidase inhibitors, nke ikpeazụ mmetụta enwekwukwa. Dabere na nke a bụ eziokwu, ọ dị mkpa iji belata onunu ogwu nke agonists na Dofaminomimetiki.

Mgbe ngalaba-ndinọ ọgwụ ọjọọ, "zyvox" na antidepressants nke inhibit uptake nke serotonin, serotonin syndrome nwere ike ime.

Na ikpe nke ngalaba-ochichi na "aztreonam" ma ọ bụ "Gentamycin" farmakinetika linezolid e hụrụ.

Co-ochichi na "Rifampicin" na-agụnye ẹsụhọde ịta makismalnaya "zyvox" - ruo 32%.

contraindications

The ọgwụ bụ adịghị anakwere maka site na ọrịa na-amụba uche na isi ma ọ bụ ọzọ mmiri n'ime ya Ọdịdị.

Ọ bụrụ na onye ọrịa na-ewe phenelzine ma ọ bụ isocarboxazid, linezolid mgbe ọ na-apụghị iwere n'oge ọgwụ, na 2 izu gasịrị.

Ọ bụrụ na ị na-apụghị ịchịkwa ọbara mgbali, na "zyvox" adịghị anakwere na-emeso ọrịa na ndị na-esonụ ọrịa:

• ejighị n'aka ọbara mgbali;
• hyperthyroidism;
• pheochromocytoma;
• nakwa dị ka a na nkwonkwo n'ikuku na agonists na Dofaminomimetiki.

Na-apụghị ime nke ịkpachara anya chọpụtara nke onye ọrịa na ihe ize ndụ nke serotonin syndrome "zyvox" enweghị ike kenyere ndị na-esonụ ọnọdụ:

• ọnụnọ carcinoid ọrịa;
• ochichi nke ọgwụ ọjọọ nke inhibit reuptake nke serotonin, tricyclic antidepressants umu triptans "Miperedina" na "buspirone".

Mbadamba ụdị "zyvox" na-contraindicated na ụmụ n'okpuru afọ 12 n'ihi na nke na-apụghị ime nke nhọrọ nke ezigbo usoro onunu ogwu.

The ọgwụ na-owụt maka ọgwụgwọ mgbe uru na-atụ anya na ya ka ihe ize ndụ ndị na-esonụ mgbe:

• gbasara akụrụ na hepatic insufficiency;
• systemic na-efe efe;
• Pregnancy na lactation.

Nwere ike ịbụ a ọgwụ ovadozu?

Na Clinical ọmụmụ, nakwa dị ka ihe ọzọ were nke nkwadebe "zyvox" n'ụlọ ọgwụ ma ọ bụ obodo-enwetara ngwa ovadozu chọpụtaghị. Mgbe nke a emee na-atụ aro symptomatic ọgwụ.

Nchekwa na ntọhapụ

Drug "zyvox" dị na pharmacies site ọgwụ. Nọgidenụ na-ọ ga-abụ na ebe, belatara mmiri ma kpọmkwem ìhè anyanwụ na okpomọkụ karịa 30˚C, igbochi ụmụaka ohere.

analogs

N'ihe banyere nke unacceptability ọgwụgwọ "zyvox" analogs nke myirịta echiche nwere ike ikenye isi ọgwụgwọ mmetụta nke nọ n'ọrụ umi:

• Mgbe oyi baa na bronchitis - "Doxycycline hydrochloride" "Bronhorus" "Arlette".
• Mgbe bakteialnyh efe efe - "Chloramphenicol 0,25 g", "Vankomabol", "Lifakson".
• Na-efe efe nke anụ - "Benzathine Benzylpenicillin", "Sulfadimetoksin".
• Mgbe nonhealing ọnyá - "Tsifaleksina sodium nnu", "Liphuzol".

Idepụta ha na a ndepụta ga naanị dọkịta, n'ihi na onye ọ bụla ọgwụ nwere ya na-egosi, contraindications, na karịsịa n'ikuku.