Proton mgbapụta inhibitors: usoro nke edinam na ngwa na nkà mmụta ọgwụ

Site proton mgbapụta inhibitors bụ ìgwè nke pharmacological mmadụ na belata ọnụego nke secretion nke hydrochloric acid ke afo. Inwe a kpọmkwem utịp ke secretory canaliculi, ha n'ụzọ dị irè na-eduga chọrọ ọgwụgwọ mmetụta ọnyá, erosive mgbu, Gerd. The otu na-agụnye a plurality nke ọgwụ ọjọọ nke yiri chemical Ọdịdị, ma na-enwe dị iche iche pharmacodynamic kwa, i.e. na ihe ọgwụ ọjọọ eme ihe na secretory mkpụrụ ndụ, ma na-eme otú dị iche iche kasịnụ na na dị iche iche gbapụrụ ọsọ.

Proton mgbapụta inhibitors: molekụla akụkụ mmetụta preparations

Proton mgbapụta bụ a mgbagwoju protein Ọdịdị achị penetration nke hydrogen ion na gastric lumen. Ọ mejupụtara abụọ na ya dissimilar ọcha, ma ọ bụghị na-akpọ subunits. Nke mbụ bụ nanị ndị na protein na e wuru si amino asịd. Na akpụkpọ ahụ cell stuffer ya na-akpa àgwà na a n'ụzọ pụrụ iche, na-agafe ya ugboro 10, nke na-eduga ná guzobe nke 5-secretory ọwa loops. Agafe uji eze nke ion ada n'ime gastric lumen na-enye ndị acidification nke ọkara na-ada ada hydrogen index. Na nke a, ọ bụ na otu nke loops bụ ifịk center nke protein - a usoro nke 800 amino asịd, nke catalyzes mmebi nke ATP, isi ike cell mkpụrụ.

Ọzọ subunit bụ a protein mgbagwoju na-emi esịnede nke polypeptide usoro, karị a na-nyere iwu Ọdịdị na glycoprotein ígwè. Ihe karịrị nke molekul bụ n'èzí cytoplasm, na a akụkụ nke glycoprotein bụ eleghị anya ekstratsitoplazmaticheskim ihe nnabata mgbagwoju na kọwakwara mgbaàmà nke ebighị nke enzyme H + \ K + -ATPase. Na nke a na protein òkè nke molekul obe akpụkpọ otu ugboro, na-ekwu ọnụ ahịa ya dị ka a na njikọ mmewere n'etiti elu na mbụ ihe nnabata subunit maka eduzi a catalytic mmeghachi omume nke njikọ nke protons.

Ntem, Ọdịdị nke ahụ proton mgbapụta secretory tubules parietal mkpụrụ ndụ nwere ike ikwubi otú mfe n'ụzọ pụrụ ebelata secretion nke H + n'ime ahu oghere. The kasị zie ezi n'onwe - bụ mgbochi nke enzyme maka njikọ na-eme ka proton mgbapụta inhibitors.

Jiri nke inhibitors na-adakarị omume

Na nkà mmụta ọgwụ, proton mgbapụta inhibitors na-n'ọtụtụ ebe, karịsịa na Gastroenterology, nke na-metụtara ha nwere ike iji belata na acidity nke gastric secretion, ma si otú belata ike nke mmetụta na-ebibi on afo mgbidi, nke dị mkpa karịsịa mgbe ọ na-mkpali. Na nke a na ọgwụgwọ mmetụta dị onwe ha nke etiology nke mkpali usoro, dị ka ọ na-ewepụ site na ike ike mmetụta nke gburugburu ebe obibi na ike n'ezi ihe nke ahu. Ọzọkwa ụdịdị dị iche iche nke pathologies nke ọgwụgwọ maka irè ojiji nke proton mgbapụta inhibitors e gbasaa site gastric ọnyá afọ na duodenal ọnyá afọ, erosive na-abụghị erosive Gerd iche-iche.

Otu n'ime ihe ndị kasị nkịtị ọgwụ na-agụnye proton mgbapụta inhibitors na-esonụ ọnyà aha omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, na ndị ọzọ. N'etiti ha bụ ndị ahia aha kwụpụta, dị ka "Omez". Ọgwụ ndị dị na Capsule ụdị. Ha na-e jikwa ọnụ na ọgwụ onunu ogwu nke a ọkachamara, nke dịgasị dabere ụdị ọrịa. Mgbe ohere onwe-ochichi, dị ka e nwere otu ìgwè nke ndị ọrịa na-eme mkpesa nke n'oge a kara exacerbation nke ala ala gastric ma ọ bụ duodenal ọnyá afọ. N'ọnọdụ ndị ọzọ, n'ikuku na-negotiated na dọkịta n'oge nke mbanye.